Korsana Biosciences Strengthens Leadership with Executive and Board Appointments to Support Next Phase of Growth

Matthew Leoni, M.D., appointed Chief Medical Officer and Gan Wei, Ph.D., appointed Chief Technical Officer

Heidi Henson appointed to Board of Directors and will serve as Chair of the Audit Committee

Leadership additions enhance clinical, technical and governance capabilities as Korsana advances lead program KRSA-028 for the treatment of Alzheimer's disease

WALTHAM, Mass.--(BUSINESS WIRE)--Korsana Biosciences, Inc. (“Korsana” or the “Company”), a biotechnology company discovering and developing novel therapies to reduce the burden of neurodegenerative diseases, today announced the appointments of Matthew Leoni, M.D., as Chief Medical Officer, Gan Wei, Ph.D., as Chief Technical Officer, and Heidi Henson as a member of its Board of Directors, where she will serve as Chair of the Audit Committee. Collectively, these appointments strengthen Korsana's leadership team as the Company advances KRSA-028, its lead THETA™-enabled therapeutic candidate for Alzheimer's disease, toward clinical development while continuing to progress its pipeline of potential best-in-class therapies for neurodegenerative diseases.

"We are delighted to welcome Matt, Gan, and Heidi to Korsana as we enter our next phase of growth," said Jonathan Violin, Ph.D., President and Chief Executive Officer of Korsana. "As Korsana advances toward becoming a clinical-stage company, we are assembling a leadership team with the expertise needed to execute our strategy and position Korsana for long-term success. Matt, Gan, and Heidi each bring exceptional experience building and scaling innovative biotechnology organizations, and together they significantly strengthen our ability to advance KRSA-028 and realize the full potential of our THETA™ platform for patients with neurodegenerative diseases."

Korsana continues to expect its previously announced merger with Cyclerion Therapeutics to close in the third quarter of 2026, subject to the satisfaction of customary closing conditions. Upon completion of the transaction, the combined company plans to operate under the name Korsana Biosciences, Inc. and trade on Nasdaq under the ticker symbol “KRSA.” The Company is also advancing KRSA-028 toward the clinic, with Phase 1 healthy volunteer data expected in mid-2027 and interim proof-of-concept data evaluating amyloid plaque clearance in Alzheimer's disease patients anticipated by the end of 2027 or the first quarter of 2028.

Matthew Leoni, M.D., Chief Medical Officer

Dr. Leoni is an accomplished drug developer whose work in early- and late-stage clinical development has contributed to the advancement and approval of multiple innovative therapies over more than 20 years in the biopharmaceutical industry. Most recently, he served as Chief Medical Officer of Merida Biosciences, where he joined following its Series A financing, built the development organization, and advanced its lead program through IND clearance and into the clinic. Prior to Merida, he was Senior Vice President of Development at Cerevel Therapeutics, where he was a member of the company’s founding leadership team and helped guide the organization through multiple clinical milestones, its public debut, and subsequent acquisition by AbbVie. Earlier in his career, Dr. Leoni held clinical development leadership roles at Otsuka, Novartis, Galderma, and Immunomedics. He earned his M.D. from the University of Pennsylvania School of Medicine, an M.B.A. in Pharmaceutical Management from Drexel University, and a B.A. in Biology from Franklin & Marshall College.

Gan Wei, Ph.D., Chief Technical Officer

Dr. Wei brings more than 25 years of experience in biologics manufacturing process development, commercialization, and lifecycle management. Most recently, he served as Senior Vice President of Global Technical Operations at Zenas BioPharma. Previously, he held leadership positions at Voyager Therapeutics and TESARO/GSK, following earlier roles of increasing responsibility at Shire Pharmaceuticals, Eli Lilly and Company, and Momenta Pharmaceuticals. He earned his Ph.D. in Chemical and Biochemical Engineering from the University of Maryland, Baltimore County, and his B.S. in Biochemical Engineering from East China University of Science and Technology.

Heidi Henson, Board Director and Chair of the Audit Committee

Ms. Henson brings more than 20 years of financial operations experience across public and private biopharmaceutical companies. She currently serves on the boards of directors of Lisata Therapeutics, PepGen Inc., and Perspective Therapeutics, Inc. Most recently, she served as Chief Financial Officer of Pardes Biosciences, Inc. through its acquisition. Previously, she served as Chief Financial Officer of Imbria Pharmaceuticals, Kura Oncology, Wellspring Biosciences and its parent company, Araxes Pharma LLC. Ms. Henson began her career in auditing at PricewaterhouseCoopers LLP, where she served both public and private companies. She earned a Bachelor of Accountancy from the University of San Diego.

About Korsana Biosciences

Korsana Biosciences was founded to reduce the burden of neurodegenerative diseases for patients and caregivers. Developed in partnership with Paragon Therapeutics, Therapeutic Targeting (THETA™) is a novel blood-brain barrier-penetrant shuttle platform designed to enable dramatically higher drug concentration inside the brain and overcome the limitations of earlier shuttle technologies. Korsana is advancing a pipeline of innovative THETA-enabled therapies for neurodegenerative diseases, starting with KRSA-028 for the treatment of Alzheimer's disease. For more information, please visit www.korsana.com.

Important Additional Information

A registration statement on Form S-4, which contains a proxy statement/prospectus, has been filed by Cyclerion Therapeutics, Inc. (“Cyclerion”) in connection with a proposed reverse merger transaction between Cyclerion and the Company. This communication does not substitute for the Form S-4, proxy statement/prospectus or for any other document that Cyclerion has filed or may file with the SEC in connection with the proposed transaction.

CYCLERION INVESTORS AND STOCKHOLDERS ARE URGED TO READ THE FORM S-4, PROXY STATEMENT/PROSPECTUS AND ANY OTHER RELEVANT DOCUMENTS THAT HAVE BEEN OR MAY BE FILED WITH THE SEC, AS WELL AS ANY AMENDMENTS OR SUPPLEMENTS TO THOSE DOCUMENTS, CAREFULLY AND IN THEIR ENTIRETY IF AND WHEN THEY BECOME AVAILABLE BECAUSE THEY CONTAIN OR WILL CONTAIN IMPORTANT INFORMATION ABOUT CYCLERION, KORSANA, THE PROPOSED TRANSACTION AND RELATED MATTERS. Investors and stockholders can obtain free copies of the Form S-4 and other documents filed by Cyclerion with the SEC (when they become available) through the website maintained by the SEC at www.sec.gov. In addition, investors and stockholders should note that Cyclerion communicates with investors and the public using its website (www.cyclerion.com) and the investor relations website (www.ir.cyclerion.com) where anyone is able to obtain free copies of the Form S-4 and other documents filed by Cyclerion with the SEC and stockholders are urged to read the Form S-4 and the other relevant materials when they become available before making any voting or investment decision with respect to the proposed transaction.

No Offer or Solicitation

This communication is not intended to and does not constitute (i) a solicitation of a proxy, consent or approval with respect to any securities or in respect of the proposed transaction between the Company and Cyclerion Therapeutics, or (ii) an offer to sell or the solicitation of an offer to subscribe for or buy or an invitation to purchase or subscribe for any securities pursuant to the proposed transaction or otherwise, nor shall there be any sale, issuance or transfer of securities in any jurisdiction in contravention of applicable law. No offer of securities shall be made except by means of a prospectus meeting the requirements of the Securities Act or an exemption therefrom. Subject to certain exceptions to be approved by the relevant regulators or certain facts to be ascertained, the public offer will not be made directly or indirectly, in or into any jurisdiction where to do so would constitute a violation of the laws of such jurisdiction, or by use of the mails or by any means or instrumentality (including without limitation, facsimile transmission, telephone and the internet) of interstate or foreign commerce, or any facility of a national securities exchange, of any such jurisdiction.

NEITHER THE SEC NOR ANY STATE SECURITIES COMMISSION HAS APPROVED OR DISAPPROVED OF THE SECURITIES OR DETERMINED IF THIS COMMUNICATION IS TRUTHFUL OR COMPLETE.

Participants in the Solicitation

Cyclerion, Korsana and their respective directors and executive officers may be deemed to be participants in the solicitation of proxies from stockholders in connection with the proposed transaction. Information about Cyclerion’s directors and executive officers including a description of their interests in Cyclerion is included in Cyclerion’s Annual Report on Form 10-K, as filed with the SEC on March 30, 2026 and amended on April 30, 2026, and in subsequent reports filed with the SEC. Additional information regarding these persons and their interests in the proposed transaction are included in the Form S-4 relating to the proposed transaction filed with the SEC. These documents can be obtained free of charge from the sources indicated above.

Forward-Looking Statements

This communication contains forward-looking statements (including within the meaning of Section 21E of the Exchange Act and Section 27A of the Securities Act). The words “anticipate,” “believe,” “contemplate,” “continue,” “could,” “estimate,” “expect,” “intends,” “may,” “might,” “plan,” “possible,” “potential,” “predict,” “project,” “should,” “will,” “would” and similar expressions (including the negatives of these terms or variations of them) may identify forward-looking statements, but the absence of these words does not mean that a statement is not forward-looking. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including without limitation, statements regarding: the development, potential benefits and therapeutic potential of KRSA-028; the Company having a pipeline of potential best-in-class therapies for neurodegenerative diseases; the strength of the Company’s leadership team to position the Company for long-term success, advance KRSA-028 into the clinic, and realize the full potential of the THETA platform; the expected timing of the closing of the merger with Cyclerion Therapeutics; the expected name, Nasdaq listing and ticker symbol of the combined company following completion of the merger; and the expected timing of clinical data from the KRSA-028 research program.

The forward-looking statements contained in this communication are based on management’s current expectations. These statements are neither promises nor guarantees, but involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements, including without limitation, the following: risks associated with the Company’s ability to manage expenses and unanticipated spending and costs that could reduce the Company’s cash resources; risks related to the Company’s ability to correctly estimate its operating expenses and other events; changes in capital resource requirements; risks related to the inability of the Company to obtain sufficient additional capital to continue to advance its product candidates or its preclinical programs; the ability of the Company to obtain, maintain and protect its intellectual property rights, in particular those related to its product candidates; the Company’s ability to advance the development of its product candidates or preclinical activities under the timelines it anticipates in planned and future clinical trials; the Company’s ability to replicate in later clinical trials positive results found in preclinical studies and early-stage clinical trials of its product candidates; the Company’s ability to realize the anticipated benefits of its research and development programs, strategic partnerships, licensing programs or other collaborations; regulatory requirements or developments and the Company’s ability to obtain necessary approvals from the U.S. Food and Drug Administration or other regulatory authorities; changes to clinical trial designs and regulatory pathways; changes in expected or existing competition; legislative, regulatory, political and economic developments; and those risks and uncertainties and other factors more fully described in the registration statement on Form S-4 and in other filings made by Cyclerion with the SEC from time to time and available at www.sec.gov. Any such forward-looking statements represent management’s estimates as of the date of this release. We undertake no obligation to update such statements to reflect subsequent events or circumstances, except as otherwise required by securities and other applicable law.