Foundation Medicine and Collaborators to Share Scientific Advances at AACR22 Reinforcing the Power of Genomic Testing in Precision Cancer Care

New studies demonstrate the ability of Foundation Medicine’s portfolio of tests to improve treatment options for patients, and reinforce the company’s role as an essential partner to researchers

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Foundation Medicine, Inc. today announced that the company and its collaborators will present a total of nine studies, including two clinical science symposia presentations and seven poster discussions, at the 2022 American Association for Cancer Research (AACR) Annual Meeting from April 8-13.

Highlights of these presentations include:

• Two studies spotlighting the concordance between Foundation Medicine’s tissue and blood-based comprehensive genomic profiling (CGP) tests and their complementary value as tools to provide genomic insights to researchers and clinicians.
• Data on Foundation Medicine’s new algorithm to predict homologous recombination deficiency (HRD) status and identify patients who may be candidates for PARP inhibitors across multiple disease types. Patient identification for PARP inhibitors remains a challenge, but these findings suggest that HRD status, including indel and copy number features, is associated with instability beyond ovarian cancer.
• A new study leveraging existing data to identify 165 ancestry-associated features across multiple common cancer types. These findings help address the lack of knowledge about ancestry-specific alterations in an effort to overcome barriers to implementing precision medicine, including inequities in genetic testing, targeted treatment and clinical trial design for cancer patients from underserved populations.

“Data being presented at this year’s AACR meeting emphasize our role as an essential partner for our collaborators who are working to identify patients most likely to benefit from new precision therapies,” said Priti Hegde, PhD, chief scientific officer at Foundation Medicine. “Our research also highlights how the data derived from our portfolio of tests can shape the future of cancer care and research, including through our novel HRD algorithm.”

The following is a list of abstracts that will be presented at the meeting. To access all abstracts being presented at AACR, please visit AACR.org.

Follow Foundation Medicine on Twitter and LinkedIn for more updates from #AACR22 and visit us in person at booth #2301.

Abstract #	Title	Collaborator	Product
Clinical Science Symposia
2139 Monday, April 11 2:35 PM - 2:50 PM	Evaluation of tissue- and plasma-derived tumor mutational burden and genomic alterations of interest from the CheckMate 848 clinical trial	Bristol Myers Squibb	Clinical trial assay based on FoundationOne^® CDx & Foundation Medicine bTMB Clinical Trial Assay
CT031 Monday, April 11 3:20 PM - 3:30 PM	TALAPRO-1: Talazoparib monotherapy in metastatic castration-resistant prostate cancer (mCRPC) with tumor DNA damage response alterations (DDRm)—Exploration of genomic loss of heterozygosity (gLOH) and potential associations with antitumor activity	Pfizer	Clinical trial assay based on FoundationOne^® CDx
Posters
57/18 Sunday, April 10 1:30 PM – 5:00 PM	Patients with germline ATM mutations develop clonal hematopoiesis characterized by co-occurrence of multiple somatic ATM alterations		FoundationCore^®
753/9 Monday, April 11 9:00 AM – 12:30 PM	Comprehensive genomic profiling (CGP) reveals site-specific enrichment of immunotherapy biomarkers and targetable alterations in non-small cell lung cancer (NSCLC) metastasis		FoundationCore^®
798/7 Monday, April 11 9:00 AM – 12:30 PM	Comprehensive genomic profiling of tissue and liquid biopsies reveals the landscape of reversion mutations		FoundationCore^®
1166/13 Monday, April 11 9:00 AM – 12:30 PM	Leveraging existing data to identify ancestry-associated features across multiple cancer types	Dana Farber Cancer Institute	FoundationCore^®
1243/15 Monday, April 11 9:00 AM – 12:30 PM	Identification of aneuploidy biomarkers associated with response to first-line treatment of metastatic pancreatic cancer		Foundation Medicine and Flatiron Health’s Clinicogenomic Database
1249/21 Monday, April 11 9:00 AM – 12:30 PM	Development of a pan-cancer algorithm to predict homologous recombination deficiency and sensitivity to PARPi therapy	University of Minnesota	Foundation Medicine and Flatiron Health’s Clinicogenomic Database & FoundationCore^®
3413/19 Tuesday, April 12 1:30 PM – 5:00 PM	Clinical utility of circulating tumor DNA sequencing with a large panel: The experience of Gustave Roussy/ National Center for Precision Medicine (PRISM)	Gustave Roussy Cancer Center	FoundationOne^® Liquid CDx

About Foundation Medicine

Foundation Medicine is a molecular information company dedicated to a transformation in cancer care in which treatment is informed by a deep understanding of the genomic changes that contribute to each patient's unique cancer. The company offers a full suite of comprehensive genomic profiling assays to identify the molecular alterations in a patient’s cancer and match them with relevant targeted therapies, immunotherapies and clinical trials. Foundation Medicine’s molecular information platform aims to improve day-to-day care for patients by serving the needs of clinicians, academic researchers and drug developers to help advance the science of molecular medicine in cancer. For more information, please visit www.FoundationMedicine.com or follow Foundation Medicine on Twitter and LinkedIn.

Foundation Medicine^®, FoundationOne^®, and FoundationCore^® are registered trademarks of Foundation Medicine, Inc.

Source: Foundation Medicine