Uqora® Launches Flush Advanced+, an Innovative, Science-Backed Solution for Recurrent Urinary Tract Infections

Approximately 60% of women will experience a UTI in their lifetime² — Flush Advanced+ helps to reduce the risk of recurrent UTIs in healthy women‡, delivering an effective, comprehensive solution to support women’s urinary health

SAN DIEGO--(BUSINESS WIRE)--Uqora, the rapidly growing and cutting-edge urinary tract health brand, today announces the launch of Flush Advanced+, a science-backed solution for recurrent urinary tract infections (UTIs), now available online at Uqora.com.

Following the success of Uqora^® Flush, America’s #1 Urinary Tract Drink Mix*, Uqora is expanding its comprehensive urinary care portfolio with Flush Advanced+, a formula designed for women with recurrent urinary tract challenges. With a clinical dose of whole-fruit cranberry powder and clinical-strength d-mannose in each serving, Flush Advanced+ helps to reduce the risk of recurrent UTIs in healthy women‡.

“Recurring urinary tract infections place a persistent, undue burden on women’s health and wellbeing. Our goal was to develop a formula that delivers advanced support to reduce the risk of UTIs before they happen,” said Carrie Schaefer, Vice President, Commercial, Uqora. “Flush Advanced+ gives women with recurrent urinary tract challenges access to an effective, easy-to-use solution to take control of their urinary health.”

Urinary Tract Infections (UTIs) are one of the most common infections in the United States, with around 11 million cases reported annually¹. Approximately 60% of women will experience a UTI in their lifetime, and of this group, 20-40% will experience a second UTI, with 25-50% of these women going on to experience multiple recurrent UTIs, underscoring the significant burden of recurrent UTIs on wellbeing and quality of life². These cases also have a sizable impact on healthcare costs, with approximately $5 billion spent annually on indirect and direct costs associated with the evaluation and treatment of UTIs in the United States¹.

Designed with dual-action anti-adhesion activity, Flush Advanced+’s hero ingredients, d-mannose and whole-fruit cranberry powder, work in different but complementary ways to bind to non-beneficial microorganisms and help flush them from the urinary tract – offering both fast-acting and long-lasting support. Going beyond single-ingredient products with cranberry or d-mannose alone, this solution combines these key ingredients in a convenient, easy-to-drink Triple Berry Flavor drink mix formula.

With the launch of Flush Advanced+, Uqora has also announced a cutting-edge evolution on its well-known three-part proactive urinary tract health supplement regimen, the Complete Regimen. The new Flush Advanced+ Regimen delivers the same trusted approach, enhanced with more comprehensive support – featuring Uqora Flush Advanced+, Uqora Defend, a proactive bladder and urinary health support supplement, and Uqora Promote, a vaginal probiotic. These products in the Flush Advanced+ Regimen are designed to work with each other to upgrade your proactive urinary tract health routine.

About Uqora

Uqora^® is a San Diego-based healthcare company specializing in urinary tract health and is part of Pharmavite’s market-leading women’s health portfolio, which includes Bonafide Health, LLC and the Equelle^® brand. Uqora's roots lie in proactive urinary tract care and research, leading the way in the development of next-generation health products. Uqora continues to expand high-quality research in the world of urinary health in cutting-edge, effective ways. With Uqora, consumers can address every aspect of their urinary tract health, from proactive care to diagnostics and UTI symptom management. Visit www.uqora.com to learn more.

About Pharmavite

Pharmavite is a pioneer in the health and wellness industry, earning the trust of consumers, healthcare professionals and retailers by developing innovative vitamin and supplement solutions backed by science that adhere to strict manufacturing practices. Through its Nature Made^®, Bonafide^®, Nature Made^® Wellblends™, Equelle^®, MegaFood^®, and Uqora^® brands, Pharmavite is dedicated to helping people live healthier, more vital lives. Based in California, Pharmavite is a subsidiary of Otsuka Pharmaceutical Co., Ltd. Visit www.pharmavite.com and follow us on LinkedIn for the latest news and information about Pharmavite and its brands.

‡Consuming 500 mg in one stick pack each day of this whole cranberry fruit powder dietary supplement in Flush Advanced+ may help reduce the risk of recurrent urinary tract infection (UTI) in healthy women. FDA has concluded that there is limited scientific evidence supporting this claim.

*Source: Circana, LLC, Total US – Multi Outlet, Urinary Tract Drink Mix, Dollar Sales, 52 WE Apr 20, 2025

¹ Tamadonfar, K. O., et al. "Reaching the end of the line: urinary tract infections." Microbiology Spectrum 7.3 (2019): 10-1128.

² Anger, J., et al. "Recurrent Uncomplicated Urinary Tract Infections in Women: AUA/CUA/SUFU Guideline (2022)."