Cadence Raises $100M Series C Led by Spark Capital to Automate Chronic Care

This new investment will help scale AI agents to meet the needs of over 56 million older adults with chronic disease amid a deepening clinician shortage.

NEW YORK--(BUSINESS WIRE)--Cadence, the clinical AI company managing chronic care for older adults, announced a $100 million Series C, amid adoption of its AI-powered care model across the nation's leading health systems.

The Series C was led by Spark Capital. Thrive Capital, General Catalyst, Coatue, B Capital, Corewell Health Ventures, Memorial Hermann, and Duke Health participated in the round.

Today, Cadence also announced new affiliations with Duke Health, a world-class academic health care system serving patients across North Carolina, and Texas Health Resources, the nonprofit health system that cares for more patients in North Texas than any other. Now working alongside over 20 leading health systems, Cadence treats more than 100,000 active patients, has demonstrated significant clinical improvements in peer-reviewed literature, and saves Medicare roughly $2.7 million every week¹. The company tripled annual recurring revenue in 2025.

“We believe the most consequential AI companies of the next decade will be built in categories where the technology changes the underlying mechanics of the business. Cadence has done the hardest work first – demonstrating clinical outcomes, building trust with the country's leading health systems, and proving out the safe and effective deployment of AI inside care delivery,” said Will Reed, partner at Spark Capital and new Cadence board member. “There is no other AI care platform in the country with this combination of scale, peer-reviewed clinical outcomes, and economic proof.”

“At Duke Health, our mission is to advance the health of our patients and the communities we serve. The moments that matter most for a patient's health often happen at home, not in the clinic,” said Jeffrey Ferranti, MD, MS, Senior Vice President and Chief Digital Officer of Duke Health. “With Cadence, we stay connected to patients with chronic conditions around the clock, monitoring their health continuously so we can intervene early and keep them healthy. Together, we're reimagining what care can be: healthier patients and a stronger, more affordable health system for all.”

Cadence's Clinical Intelligence identifies risk early and acts proactively between visits, keeping older adults healthier over time while extending clinicians so they can focus on the care that requires them. Integrated directly into partner health systems' medical groups, electronic medical records, and clinical workflows, supervised AI agents monitor patient vitals daily, support timely medication adjustments, and enable highly personalized lifestyle coaching.

Chronic disease is the single largest driver of healthcare spending in America, and a significant amount of that cost is avoidable. Cadence is building AI with a specific mandate: extend our clinical workforce while driving down the costs that accumulate when chronic disease goes unmanaged between visits. As AI reshapes the economics of care delivery, Cadence is designed to be the model that bends the cost curve without compromising quality, proving technology’s value as a deflationary force in American healthcare.

“We built Cadence to solve the clinical labor constraint at the heart of the chronic disease crisis. Our AI automates care under close supervision, guided by our medical group, governed by our health system clinical protocols, and reimbursed through billing infrastructure and at-risk contracts,” said Chris Altchek, founder and CEO of Cadence. “We're treating 100,000 patients with that system today, alongside partners committed to changing the status quo in chronic care. This investment builds the infrastructure to treat millions.”

By keeping patients consistently engaged between visits, Cadence creates the real-time data foundation needed for AI to be effective in enabling enhanced care. The median response time for incoming vitals alerts is now just 3.5 minutes, with 55% resolved appropriately without the need for human adjustment.

Across peer-reviewed studies and real-world deployments, Cadence's model has produced validated outcomes including a 230% increase in heart failure patients on guideline-directed medical therapy² and a 70% relative increase in blood pressure control for hypertension patients³, as well as a 27% reduction in hospital admissions and $1,302 per-patient annual reduction in total cost of care¹. Published results are consistent across rural and underserved communities and show that Cadence’s model of Remote Patient Care returns more than $3 to Medicare for every dollar spent¹.

With this new capital, Cadence will focus on expansion across new health systems, advancement of Cadence's AI agents, and growth in value-based care models.

For more information visit www.cadence.care.

About Cadence

Cadence is the clinical AI company automating the treatment of chronic disease. Its Clinical Intelligence takes on the routine, high-volume work of chronic care – monitoring patients, surfacing risks, and coordinating action – so clinicians can focus on the decisions that require them. Grounded in partnerships with more than 20 leading health systems, deep EMR integrations, dedicated medical group, and experience serving a population of more than 100,000 patients, the system learns from real-world care delivery, improving as it scales. Cadence has been recognized by TIME as one of the Top 100 HealthTech Companies and by LinkedIn as a Top Startup (#4, 2025). To learn more, visit www.cadence.care.

¹ Feldman D, et al. The Impact of a Remote Patient Care Program on Health Care Costs and Utilization Among Medicare Patients With Chronic Disease. Mayo Clinic Proceedings: Innovations, Quality & Outcomes. Volume 10, Issue 1, Feb. 2026. https://doi.org/10.1016/j.mayocpiqo.2025.100679.
² Feldman D, et al. Leveraging remote patient monitoring to effectively put the heart failure guidelines to practice. J Card Fail. Volume 30, Issue 9, 2024. https://doi.org/10.1016/j.cardfail.2024.04.018.
³ Feldman D, et al. Clinical and Engagement Results of a Nationwide Comprehensive Remote Patient Care Hypertension Program. Journal of the American College of Cardiology: Advances. Volume 4, No. 7, 2025. https://doi.org/10.1016/j.jacadv.2025.101892.