MASSIVE BIO Delivers on CMS Interoperability Vision with Live Patient Connect App and AI Trial Matching Assistant

BOCA RATON, Fla.--(BUSINESS WIRE)--In direct support of the White House and CMS’s bold initiative to “Make Health Tech Great Again,” Massive Bio, leader in AI-enabled oncology trial matching, announced its full alignment with the CMS Health Tech Ecosystem and reaffirmed its mission to modernize clinical trial access through secure, AI-powered patient-facing technology. With its Patient Connect app and intelligent assistant DrArturoAI already live and serving patients, Massive Bio stands as one of the first organizations actively delivering on CMS’s interoperability framework at scale.

“We’re not waiting for transformation, we’ve already launched it,” said Selin Kurnaz, PhD, CEO and Co-Founder of Massive Bio. “Patient Connect represents a new era of patient empowerment: secure identity, real-time data access, AI-guided decision-making. We’ve operationalized CMS’s vision, and we’re proud to serve the public with technology that puts them in control of their care journey.”

Patient Connect enables individuals to upload and verify medical records, match to clinical trials using AI, communicate with coordinators, and share data securely with providers. Already in use by thousands of cancer patients globally, the platform integrates key CMS features such as “kill the clipboard” (FHIR-based digital check-in), IAL2/AAL2 identity verification, and Medicare connectivity.

“This is infrastructure for health equity,” said Cagatay Culcuoglu, CTO and Co-Founder. “We’ve engineered Patient Connect to comply with FHIR standards, Smart Health Cards, and seamless credentialing, removing fragmentation and putting data back into the hands of those it belongs to: the patient.”

The company’s virtual assistant, DrArturoAI, complements the app by offering conversational, context-aware AI support. Patients can receive educational guidance, symptom triage, care navigation, and trial opportunities; all transparently flagged when AI-generated and seamlessly integrated with provider care pathways.

“With DrArturoAI, we’ve built something that feels human, helpful, and honest,” said Dr. Arturo Loaiza-Bonilla MD, Chief Medical Officer and Co-Founder. “It’s the bridge between fragmented data and actionable care. Our prescreening hubs and AI-powered analytics create a mission-control capability that works 24/7 to identify and match patients in full patient centricity. This is responsible AI in service of patients, and a model for how CMS-aligned health tech can serve every American.”

What Massive Bio Has Already Delivered
CMS Pillar	Massive Bio Implementation
Kill the Clipboard	Digital FHIR check-in, QR/Smart Health Cards, visit summaries
AI-Powered Assistant	DrArturoAI & AskFionaAI: Safe, transparent, triage & support
CMS Identity Compliance	IAL2/AAL2 credentials, Medicare notifications, HIPAA compliant
Chronic Condition Support	Trial eligibility tied to clinical record insights for cancer, obesity, prediabetes

A National Commitment to Patient-Centered Innovation

Massive Bio is actively collaborating with CMS and fellow early adopters to help operationalize the interoperability framework, participate in app store pilots for Medicare.gov, and expand patient access through aligned health systems and pharmacy networks.

“We salute CMS for spearheading a future-ready ecosystem that prioritizes transparency, equity, and access,” said Kurnaz. “This isn’t just compliance, it’s our calling.”

About Massive Bio

Massive Bio, co-founded by Selin Kurnaz, Arturo Loaiza-Bonilla, and Çağatay Çulcuoğlu, transforms the pharmaceutical value chain with AI-driven solutions. As an AI-enabled real-world data company, it streamlines the patient journey, enhances access to advanced treatment options, and optimizes clinical trials. Massive Bio collaborates with pharmaceutical companies, research organizations, and healthcare institutions worldwide. A founding member of the CancerX public-private partnership and participant in the Cancer Moonshot White House initiative, the company has received recognition from the National Cancer Institute and operates across 17 countries with a global team of over 100 employees. For more information, visit www.massivebio.com.

Explore Patient Connect → massivebio.com/patient-connect
Meet DrArturoAI → drarturo.ai