Bonerge Initiates the Human Clinical Trail Plans for GlucoSober®-Dihydroberberine and BeFisetin®-Fisetin

NEW YORK--(BUSINESS WIRE)--Bonerge is excited to announce the initiation of clinical trials for its high-quality brand ingredients, including GlucoSober and BeFisetin. These trials aim to substantiate the efficacy and safety of the products, providing more reliable options for the market.

In an era where health consciousness is on the rise, consumers are increasingly seeking high-quality dietary supplements. Bonerge is embarking on several clinical trials to make evidence-based ingredients that meet the needs of consumers.

Key Products Undergoing Clinical Trials

BeFisetin^®: This high-quality Fisetin with total flavonoids greater than 99%, Fisetin content greater than 98% and impurity smaller than 1%. Previous preclinical studies have shown that fisetin can effectively clear senescent cells, targeting one of the hallmarks of aging. [1,2] The upcoming clinical trials will further investigate BeFisetin's potential benefits to support the market.

GlucoSober^®: An ultra-pure Dihydroberberine with stable quality, GlucoSober is a derivative of the popular weight-loss supplement Berberine. While Berberine has a bioavailability of less than 1%, Dihydroberberine has shown more effective. [3] As an ultrapure product, higher purity means more active ingredients that are packed. GlucoSober is set to be the product to undergo human clinical trials to validate the benefits of Dihydroberberine.

Additionally, Bonerge will conduct clinical research on product formulations to investigate the synergistic effects of ingredients to meet personalized demand. Further details will be announced.

The Initiates of Choosing Clinical Trials
Exploring the functions and applications of ingredients requires collaboration among scientists, manufacturers, and brands. As the mainstream Dihydroberberine supplier, Bonerge continues to explore scientifically proven health longevity and metabolic health ingredients. Bonerge partners with leading brands to ensure consumers have access to high-quality products that help them to maintain a balanced blood glucose level.

About Bonerge
Bonerge is one innovative team and lab specialized in longevity and metabolic health ingredients. Bonerge closely follow up on the latest anti-aging science, develop novel longevity ingredients. Bonerge is guided by 12 hallmarks of aging. Live longer and healthier.

References
1. Yousefzadeh, Matthew J et al. “Fisetin is a senotherapeutic that extends health and lifespan.” EBioMedicine vol. 36 (2018): 18-28. doi:10.1016/j.ebiom.2018.09.015

2. López-Otín, Carlos et al. “Hallmarks of aging: An expanding universe.” Cell vol. 186,2 (2023): 243-278. doi:10.1016/j.cell.2022.11.001

3. Xu, Hong-Yu et al. “Nanoemulsion improves hypoglycemic efficacy of berberine by overcoming its gastrointestinal challenge.” Colloids and surfaces. B, Biointerfaces vol. 181 (2019): 927-934. doi:10.1016/j.colsurfb.2019.06.006