Innovations in Small Molecule Drug Delivery and Formulation, 2024 Research Report - Collaborating with CDMOs to Intensify R&D Activities - ResearchAndMarkets.com

DUBLIN--(BUSINESS WIRE)--The "Innovations in Small Molecule Drug Delivery and Formulation" report has been added to ResearchAndMarkets.com's offering.

Small molecules, which are the leading drug class across indications, face several issues that threaten their drug delivery efficacy. They suffer from off-target effects, poor bioavailability, low solubility, systemic toxicity, and poor permeability. While the small molecule drug development pipeline remains a leading therapeutic class, it is essential to intensify R&D to improve drug delivery approaches. This analysis of the latest advances in small molecule drug delivery covers developments in organic, inorganic, and carrier-free small molecule drug delivery systems (DDSs) as well as developments in formulations for improved patient adherence and targeted small molecule delivery.

Small molecule drug modification approaches - such as the modification of functional groups, masking undesirable chemical groups, and conjugation of targeting ligands - remain a widespread method for drug delivery. However, other approaches are emerging, including prodrug strategies, small molecule-drug conjugates (SMDCs), and multivalent delivery systems, which serve to modify the drug and achieve desirable drug properties - higher solubility and bioavailability and better targeted delivery.

As advanced technology platforms for the development of novel DDSs emerge, new small molecule DDSs experience more widespread adoption. Development has accelerated for lipid-based, polymer-based, and dendrimer DDSs. These improve the sustained release and target specificity of small molecules. For instance, cancer cells are specifically targeted using improved versions of the existing delivery systems and newer delivery systems.

Emerging smart and programmable stimuli-response delivery systems are industry-disrupting technologies that can use any type of carrier for targeted and sustained small molecule drug release. Nanocarriers and nanoformulations are a key industry trend across all delivery vehicle types under development for multiple indications. Naturally derived carriers - such as exosomes and blood components - are under research for their biocompatibility and biodegradability properties. Lipid-based carriers lead in the oral formulations segment, especially for small hydrophobic molecules. Carrier-free self-assembly nanodrugs are emerging as the next generation of small molecule drugs.

These new developments and approaches in formulations help improve patient adherence. Dry powder inhalable formulations for cancer and pulmonary diseases increase the bioavailability of small molecule drugs and patient adherence, especially in comparison to injectables. Oral formulations and injectables remain one of the most widely adopted modes of administration for cancer and neurological and pulmonary diseases, while the sublingual mode is under exploration.

Key Topics Covered:

Strategic Imperatives

• Why Is It Increasingly Difficult to Grow?
• Factors Creating Pressure on Growth
• The Strategic Imperative
• The Impact of the Top 3 Strategic Imperatives on Advances in the Small Molecule Drug Delivery Industry
• Growth Opportunities Fuel the Growth Pipeline Engine
• Research Methodology

Growth Opportunity Analysis

• Growth Drivers
• Growth Driver Analysis
• Growth Restraints
• Growth Restraint Analysis
• Scope of Analysis
• Segmentation
• Challenges in Small Molecule Drug Delivery

Drug Delivery Approaches

• Trends in Small Molecule Drug Delivery
• Introduction to Small Molecule Drug Delivery Approaches
• Drug Modification Approaches That Enhance Bioavailability
• Key Innovators in Drug Modification Approaches
• Ligand Conjugation for an Improved Targeted Delivery
• Key Innovators - Ligand Conjugation
• Carriers
• Liposomes
• Lipid NPs
• Niosomes
• Key Innovators in Emerging Lipid-based Organic Carriers
• Polymeric Micelles
• Polymeric NPs
• Polymeric Microspheres
• Key Innovators in Polymer Based Carriers
• Lipid-polymer Hybrid NPs
• Hydrogels
• Dendrimers
• Carbon Dots
• DNA Nanobots
• Key Innovators in Emerging Organic Carriers
• Naturally Derived Carriers
• Inorganic Carriers
• Carrier-free Drugs
• Emerging Platforms - Programmable DDSs
• Smart Stimuli-response Systems
• Nanoparticles as Carriers for DDSs
• The Role of AI in Selecting Drug Delivery Vehicles and Formulations

Formulations

• Small Molecule Drug Delivery Formulation Systems
• Small Molecule Mode of Administration and Formulations
• The Role of Excipients in Formulation
• Inhalable Powder Formulations
• Key Innovators
• LNPs in Oral Formulations
• Key Innovators and Innovations in Oral Formulation and Delivery
• Polymeric DDSs in Injectables
• Key Innovators
• Developments in Buccal/Sublingual Delivery
• Small Molecule DDS Trends per Disease Area

Market Dynamics

• Small Molecule Drug Delivery Industry Players
• Collaboration Landscape for Small Molecule DDS
• Key CDMO Players Offering Advanced Drug Delivery and Formulation Platforms for Small Molecule Delivery

Growth Opportunity Universe

• Growth Opportunity 1: Collaborating with CDMOs to Intensify R&D Activities
• Growth Opportunity 2: Integrating AI for Advanced Drug Delivery Approaches
• Growth Opportunity 3: Simpler Administration Modes That Increase Patient Adherence

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