Resilience and Harvard University Announce Five-Year R&D Alliance to Incubate New Technologies, Launch Companies to Advance the Manufacture of Complex Medicines

First anticipated spinout from the alliance, Circle Therapeutics, to develop novel muscle stem cell therapies for a variety of skeletal muscle disorders

SAN DIEGO & CAMBRIDGE, Mass.--()--National Resilience, Inc. (Resilience), a manufacturing and technology company, and Harvard University have established a five-year research and development alliance with a $30 million commitment from Resilience directed toward the development of complex medicines, including biologics, vaccines, nucleic acids and cell and gene therapies.

Under the alliance agreement coordinated by Harvard’s Office of Technology Development (OTD), Resilience will fund faculty-initiated research focused on certain novel therapeutic and biomanufacturing technologies pioneered in university labs. The alliance also anticipates that these Harvard innovations may be commercially advanced by new companies formed by Resilience expressly to drive these technologies into clinical development and commercialization.

An initial technology platform has already been identified for incubation under the alliance, with promising applications in skeletal muscle disorders. In the Harvard lab of Lee Rubin, PhD, Professor of Stem Cell and Regenerative Biology, researchers have developed a means to culture millions of cells in vitro that behave like skeletal muscle stem cells (satellite cells), retaining their regenerative potential, for use in possible cell therapies. Resilience is now funding the lab’s continuing work on the platform, aiming to further validate it, in a project led by staff scientist Feodor Price, PhD.

Meanwhile, Resilience has formed an entity called Circle Therapeutics, anticipating that Circle may carry the technology forward under license.

“For six decades since the discovery of the satellite cell, it has not been possible to expand therapeutic numbers of satellite cells in vitro, until we made real headway on it at Harvard,” said Rubin. “We’re truly excited for the possible therapeutic impact of our innovations.”

“Our mission at Resilience is to make a new generation of complex medicines, such as curative gene therapies, lifesaving vaccines and immune system–boosting cell therapies more accessible to people in need,” said Rahul Singhvi, ScD, Chief Executive Officer of Resilience. “Current biomanufacturing processes pose significant hurdles to making these medicines quickly, and at scale, which is why we are excited to work with researchers at Harvard to identify and develop the technologies needed to make this future a reality.”

“The Rubin Lab’s platform to expand and maintain in vitro derived satellite cells could lead to transformative cell therapies,” said Vivian Berlin, PhD, Executive Director, HMS, at Harvard OTD, who leads OTD’s Corporate Alliances team. “With prior support from the Blavatnik Biomedical Accelerator, the team has compellingly demonstrated the clinical relevance of this work. Now with Resilience’s focused funding and experience in the development of complex medicines, we hope to set it on a clear path toward benefiting patients.”

Going forward, Resilience and Harvard will jointly issue a call for proposals to identify additional research projects to be funded at Harvard. Under the terms of the alliance, Resilience will receive an option to license technologies arising from funded projects.

“This research alliance with Resilience will help support biomedical innovation at Harvard,” said Isaac Kohlberg, Harvard’s Chief Technology Development Officer and Senior Associate Provost. “Collaborating to both advance Harvard science and place arising technologies with dedicated new ventures, we can provide yet another valuable source of support and industry expertise to translational biomedical researchers across Harvard’s schools as they seek to impact human health for the better.”

About Resilience

Resilience is a manufacturing and technology company dedicated to broadening access to complex medicines and protecting biopharmaceutical supply chains against disruption. Founded in 2020, the company is building a sustainable network of high-tech, end-to-end manufacturing solutions with the aim to ensure the medicines of today and tomorrow can be made quickly, safely, and at scale. Resilience seeks to offer regulatory capabilities and flexible and adaptive facilities to serve partners of all sizes. By continuously advancing the science of biopharmaceutical manufacturing and development, Resilience aims to free partners to focus on the discoveries that improve patients’ lives. For more information, visit

About Harvard Office of Technology Development

Harvard’s Office of Technology Development (OTD) promotes the public good by fostering innovation and translating new inventions made at Harvard University into useful products that are available and beneficial to society. Our integrated approach to technology development comprises sponsored research and corporate alliances, intellectual property management, and technology commercialization through venture creation and licensing. More than 90 startups have launched to commercialize Harvard technologies in the past 5 years, collectively raising more than $4.5 billion in financing. To further bridge the academic-industry development gap, Harvard OTD manages the Blavatnik Biomedical Accelerator and the Physical Sciences & Engineering Accelerator. For more information, please visit


Ryan Flinn, Head of Communications, Resilience: / 510-207-7616

Caroline Perry, Director of Communications, Harvard OTD: / 617-495-4157

Release Summary

Resilience and Harvard University have established a five-year R&D alliance to develop complex medicines.


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Ryan Flinn, Head of Communications, Resilience: / 510-207-7616

Caroline Perry, Director of Communications, Harvard OTD: / 617-495-4157