LEO Pharma to Highlight New Data in Medical Dermatology at EADV Virtual 2020

-- Findings from clinical trials include new or additional insights across psoriasis, atopic dermatitis and chronic hand eczema --

MADISON, N.J.--(BUSINESS WIRE)--LEO Pharma Inc. today announced that data from across its dermatology portfolio of approved and investigational medicines will be presented at the 29^th Congress of the European Academy of Dermatology and Venereology (EADV), Vienna, Oct. 29-31, 2020. EADV’s 29^th Congress will be fully virtual.

Data presented span psoriasis, atopic dermatitis and chronic hand eczema. The depth of research continues to demonstrate the company’s commitment to discovering and developing innovative solutions in medical dermatology.

“Data that LEO Pharma will present at EADV build upon our commitment to help people with skin diseases around the world,” said Kim Kjoeller, Executive Vice President, Global Research and Development, LEO Pharma. “We have a legacy of being relentlessly committed to dermatology, and we are accelerating R&D efforts to expand and diversify our portfolio across a range of dermatological indications.”

Full abstracts will be available beginning Oct. 29, 2020.

Data include:

Oral Presentations

Atopic Dermatitis
Title	Presenter	Time	Session No.
Specifically targeting interleukin-13 with tralokinumab improved sleep in two Phase 3, randomised, double-blind, placebo-controlled trials in patients with atopic dermatitis	Jonathan Silverberg (Washington D.C., United States)	On-demand, 29 Oct.	Abstract ID 408 FC08: Free Communications - Atopic dermatitis and Urticaria
Impact of targeting interleukin-13 on Staphylococcus aureus colonisation: results from a Phase 3, randomised, double-blind, placebo-controlled trial with tralokinumab in adult patients with atopic dermatitis	Amy Paller (Chicago, United States)	On-demand, 29 Oct.	Abstract ID 1363 FC08: Free Communications - Atopic dermatitis and Urticaria
Chronic Hand Eczema
Title	Presenter	Time	Session No.
The topical pan-JAK inhibitor delgocitinib cream demonstrates dose response in a 16-week phase 2b trial in chronic hand eczema	Margitta Worm (Berlin, Germany)	15:45 - 16:45, 29 Oct.	Abstract ID 3094 D1T03.4: Late breaking news

e-Posters

Atopic Dermatitis
Title	Authors	Code
Conjunctivitis in tralokinumab-treated adult patients with moderate-to-severe atopic dermatitis: pooled results from five clinical trials	Wollenberg A., Beck L.A., de Bruin Weller M., Zachariae R., Olsen C.K., Thyssen J.P.	Abstract ID 1448 e-Poster Number P0216
Tralokinumab provides progressive improvements beyond week 16 in patients with atopic dermatitis with an initial partial response	Simpson E., Thyssen J.P., Flohr C., Katoh N., Papp K., Steffensen L.A., Bang B., Kuznetsova A., Blauvelt A.	Abstract ID 1440 e-Poster Number P0214
Safety of specifically targeting interleukin-13 with tralokinumab in adult patients with moderate-to-severe atopic dermatitis: pooled analysis of five randomised, double-blind, placebo-controlled Phase 3 and Phase 2 trials	Simpson E., Merola J.F., Silverberg J.I., Zachariae R., Olsen C.K., Wollenberg A.	Abstract ID 1464 e-Poster Number P0218
Vaccine antibody responses in tralokinumab-treated adult patients with moderate-to-severe atopic dermatitis: results from the 30-week Phase 2 ECZTRA 5 trial	Merola J.F., Bagel J., Almgren P., Røepke M., Grewal P.	Abstract ID 806 e-Poster Number P0181
Real world evidence of ophthalmology health care resource use in patients with atopic dermatitis in England	Oluwa F., Vilsbøll A.W., Kragh N.	Abstract ID 2780 e-Poster Number P0272

Psoriasis
Title	Authors	Code
Patients with psoriasis receiving long-term proactive or reactive management with fixed-dose combination Cal/BD foam showed sustained improvement in DLQI, PSI and EQ-5D scores, with significantly greater improvement in the proactive group	Piergiacomo Calzavara-Pinton P., Kircik L., Jalili A., Lors-Danic D., Pink A., Jensen N., Thoning H., Petersen B., Thaci D.	Abstract ID 1453 e-Poster number P1347
Patient reported outcomes in remission versus relapse in patients with psoriasis receiving treatment with fixed-dose combination Cal/BD foam from the PSO-LONG trial	Thaci D., Tyring S., De la Cueva P., Gooderham M., Petersen B., Thoning H., Jensen N., Segaert S.	Abstract ID 1722 e-Poster number P1363
Proactive management with twice-weekly topical Cal/BD foam prolongs treatment efficacy versus reactive management in patients with plaque psoriasis	Stein Gold L., Alonso-Llamazares J., Laws P., Perrussel M., Yamauchi P., Thoning H., Toxvaerd C., Sticherling M.	Abstract ID 2178 e-Poster number P1409
Proactive treatment of plaque psoriasis with twice-weekly topical Cal/BD foam is safe in patients undergoing HPA-axis testing	Papp K., Adamski Z., Guenther L., Liljedahl M., Miasik-Pogodzinska A., Holst Mørch M., Tyring S., Werschler W., Lacour J.P.	Abstract ID 2148 e-Poster number P1403
Improvements across the psoriasis disease continuum with fixed-combination Cal/BD Foam in a Phase 3, double-blind, randomized tria	Leonardi C., Veverka K., Hansen J., Yaloumis M., Stein Gold L.	Abstract ID 143 e-Poster number P1271

Find additional congress information at eadvvirtualcongress.org/. For more information about LEO Pharma, visit https://www.leo-pharma.us or www.leo-pharma.com.

NOTES TO EDITORS

About psoriasis

An estimated 125 million people worldwide live with psoriasis.¹ It is a common, chronic, immune-mediated, inflammatory disease that primarily involves the skin.² The most frequently reported symptoms include thickening and scaling of the skin, itching and erythema (superficial reddening of the skin, usually in patches).2

Psoriasis can be a painful, disabling and stigmatising condition with substantial social and psychological impact on a person’s life.2 People with psoriasis, especially those with more severe symptoms, are also at increased risk of developing other serious associated conditions,³ including heart disease^4,5,6 and metabolic diseases (a combination of diabetes, high blood pressure and obesity).⁷ Mental health complications, such as depression and anxiety, are also more common in people with psoriasis.⁸ According to the World Health Organization, the burden of living with psoriasis is underestimated and it urges for action to fight stigma and improve treatment.2

About atopic dermatitis

Atopic dermatitis (AD) is a common type of eczema that affects up to 5% of adults across the United States, Canada, Europe and Japan.⁹ It is a chronic, relapsing skin disease, characterized by severe itch, dry skin, persistent immune-mediated inflammation, and skin barrier defects.¹⁰

AD has a significant, negative impact on patients’ well-being, primarily due to the intense itch which leads to disrupted sleep and other negative consequences.10

About chronic hand eczema

Hand eczema (HE) is a heterogeneous disease with many different causes, and ranges in severity from very mild to severe. Clinically, HE is characterized by lesioned skin on the hands that may be red, patchy, swollen, scaly, cracked, or thickened, with symptoms of itch and pain. HE is considered chronic (CHE) when it lasts for more than three months or relapses twice or more per year. Painful fissures and blisters affect a person’s daily life and well-being, and can prevent manual labor, leading to significant economic loss to both individuals and society.^11,12

About LEO Pharma

LEO Pharma A/S is a leader in medical dermatology with a robust R&D pipeline, a wide range of therapies and a pioneering spirit. Founded in 1908 and owned by the LEO Foundation, LEO Pharma has devoted decades of research and development to advance the science of dermatology, setting new standards of care for people with skin conditions. LEO Pharma is headquartered in Denmark with a global team of 6,000 people, serving 92 million patients in 130 countries. In 2019, the company generated net sales of DKK 10,805 million. For more information about LEO Pharma, visit www.leo-pharma.com.

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¹ The International Federation of Psoriasis Associations. Available at: https://ifpa-pso.com/ (Accessed March 2019).

² World Health Organization (WHO). Global Report on Psoriasis. Available at: http://apps.who.int/iris/bitstream/10665/204417/1/9789241565189_eng.pdf (Accessed March 2019).

³ Reich K. J Eur Acad Dermatol Venereol 2012;26(2):3–11.

⁴ Gelfand JM, et al. JAMA 2016;296:1735–41.

⁵ Ahlehoff O, et al. Eur Heart J 2012;33:2054–64.

⁶ Lowes MA, et al. Ann Rev Immunol 2014;32:227–35.

⁷ Langan SM, et al. J Invest Dermatol 2012;132(3 Pt 1):556–562.

⁸ Dalgard F, et al. J Invest Dermatol 2015;135(4):984 –991.

⁹ Barbarot S, Auziere S et al. Epidemiology of atopic dermatitis in adults: Results from an international survey. Allergy. 2018;73(6):1284-1293. doi: 10.1111/all.13401.

¹⁰ Weidinger S, Novak N. Atopic dermatitis. The Lancet. 2016; 387:1109-22.

¹¹ Diepgen TL, Andersen K, Chosidow O, Coenraads PJ, Elsner P, English J, Fartasch M, Gimenez-Arnau A, Nixon R, Sasseville D, Agner T. Guidelines for diagnosis, prevention and treatment of hand eczema - short version. JDDG: Journal der Deutschen Dermatologischen Gesellschaft. 2015; 13(1): 77-84.

¹² Diepgen TL, Agner T, Aberer W, Berth-Jones J, Cambazard F, Elsner P, McFadden J, Coenraads PJ. Management of chronic hand eczema. Contact Dermatitis. 2007; 57: 203-210.

MAT-39238. October 2020.