Biocodex Introduces Fullify™, a First-of-Its-Kind Precision Probiotic Clinically Shown to Activate the Gut-Brain Pathway to Support Appetite Management

Backed by Over a Decade of Research, Fullify Represents a New, Biology-Driven Approach in a Category Long Dominated by Short-Term Fixes

• Created by Biocodex, the makers of Florastor^®, Fullify™ is a first-of-its-kind precision probiotic that works through the gut-brain pathway to support appetite management.
• Developed by over 10 years of research, including preclinical studies and a large placebo controlled clinical trial, Fullify represents a rare level of scientific rigor in the dietary supplement category.
• Made exclusively in France and used in Europe since 2023, Fullify is free from stimulants and drugs and fits easily into daily routines with a simple, twice-a-day capsule format.

BEDMINSTER, N.J.--(BUSINESS WIRE)--In a supplement category long dominated by stimulants, appetite suppressants and short-term fixes, Biocodex is introducing a fundamentally different approach. The science-driven health & wellness company behind Florastor^® recently announced the U.S. launch of Fullify™, a first-of-its-kind precision probiotic developed to support appetite management and weight loss by working with the body’s natural gut-brain signaling.

Developed in France and now available in the United States, Fullify is powered by Hafnia alvei HA4597^®, a clinically studied probiotic strain that supports the body’s natural fullness signals. By working through the gut-brain pathway, Fullify stimulates production of ClpB, a protein that then stimulates production of GLP-1 and PYY hormones, leading to satiety, less hunger and fewer cravings. This gut-based approach differentiates Fullify from traditional weight-management supplements and positions it as a category-defining innovation in the nutrition space.

“For decades, weight management has been treated as a discipline problem when in reality, it’s deeply biological,” said Bindu Shah, Chief Marketing Officer at Biocodex. “Fullify is the result of more than 10 years of research into the gut-brain pathway, translating real science into a completely new approach. This innovation isn’t about suppressing appetite or relying on stimulants – it’s about working with the body’s natural signaling to support more realistic and attainable outcomes. Bringing this level of science to a consumer product is incredibly meaningful to us, and it reflects a new direction for the category.”

Fullify was developed over more than 10 years of research, including two preclinical studies and a large, placebo-controlled human clinical trial, not typically conducted within the dietary supplement industry. In a 12-week clinical study of more than 300 overweight adults following a calorie-restricted diet, participants taking Hafnia alvei HA4597^® demonstrated significantly better outcomes than those following diet alone. Individuals in the Fullify group were 50 percent more likely to lose more than four percent of their body weight compared with those in the placebo group.*¹

An additional survey-based study was conducted with consumers which revealed meaningful changes beyond weight loss. Users in this study reported improved eating behaviors, increased feelings of fullness after meals and reduced cravings compared with baseline, underscoring the role that biological hunger signals, not willpower alone, play in successful weight management. These results were particularly notable given that all participants were already dieting, highlighting how supporting the body’s natural satiety mechanisms can enhance real-world outcomes.

Designed to fit easily into daily routines, Fullify is taken twice daily with meals. With consistent use alongside a calorie-conscious diet, many users report feeling fuller within about 10 days, with appetite awareness improving over time and progress becoming more noticeable within four to eight weeks. Continued daily use beyond 12 weeks may help support sustained appetite management and mindful eating habits.*

Made exclusively in France and used in Europe since 2023, Fullify is free from stimulants and drugs and is well tolerated. The supplement is available in a convenient 30-day supply and is intended for adults seeking a science-backed, biology-driven approach to appetite management. Fullify is available now at myfullify.com and Amazon, with 20 percent off through Feb 14.

For more information on Fullify, visit myfullify.com or follow the brand on Instagram and TikTok.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

1. Dechelotte et al., 2021. Clinical trial in overweight adults on a calorie-restricted diet. At 12 weeks, more participants achieved statistically significant weight loss (>3%-4%), reduced hip circumference by −2.8 cm vs. −1.64 cm (p < 0.001); user fullness and cravings assessed using validated visual analog scale (VAS) at baseline, week 8, and week 12.

About Fullify™

Fullify™ is a precision probiotic dietary supplement developed to support appetite management by helping adults feel full sooner and eat less when used with a calorie-conscious diet. Powered by Hafnia alvei HA4597^®, a clinically studied probiotic strain, Fullify works through the gut–brain pathway to support the body’s natural fullness signals. Developed over more than a decade with preclinical and clinical research, Fullify is manufactured exclusively in France, contains no stimulants or drugs, and is backed by Biocodex’s expertise in microbiome science.