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新加坡--(BUSINESS WIRE)--(美国商业资讯)-- 作为一家可提供全方位服务的国际专业临床合同研究组织 (CRO) 和科学咨询公司，Novotech（诺为泰）发布了一份全新白皮书《自身免疫性疾病B细胞清除疗法：早期临床开发关键考量》，围绕塑造新兴B细胞清除疗法开发未来的核心科学原理、临床研究要点及项目运营关键注意事项，提供切实指导。 随着药物开发企业不断探索更彻底、更持久的B细胞清除是否有助于延长缓解期并可能影响免疫系统的恢复，B细胞清除疗法已成为自身免疫性疾病研究的一个重要领域。包括体内CAR-T疗法、T细胞衔接器在内的新兴疗法，正在将有效的临床开发策略范畴扩展到现有B细胞靶向疗法之外。 本白皮书探讨了在各类治疗方法迈入临床研究阶段之后，申办方需要制定的早期开发决策。本文探讨了多个主题，涉及首个人体试验受试人群的选择、药效动力学和安全性终点的界定、剂量递增策略的制定，以及健康志愿者研究模式、纯患者研究模式，或混合研究模式的妥善确定。 此外，本文剖析了“篮式研究”如何为多种自身免疫性疾病的药物研发提供支撑，并凸显试验设计需与作用机制、疾病生物学、预计B细胞清除程度以及潜在...

SINGAPORE--(BUSINESS WIRE)--White Paper Examines Early Clinical Development of B-Cell Depletion Therapies in Autoimmune Disease...

新加坡--(BUSINESS WIRE)--(美國商業資訊)-- 作為一家可提供全方位服務的國際知名受託研究機構 (CRO) 和科學諮詢公司，Novotech發佈了一份全新白皮書《自體免疫疾病中的B細胞去除療法：早期臨床開發關鍵考量》，針對塑造新興B細胞去除療法開發未來的核心科學原理、臨床研究要點及計畫營運關鍵注意事項，提供實務導向的指引。 隨著藥物開發企業不斷探索更深層、更持久的B細胞去除是否有助於延長緩解期並可能影響免疫系統的恢復，B細胞去除療法已成為自體免疫疾病研究的一個重要領域。包括體內CAR-T療法、T細胞銜接器在內的新興療法，正在將有效的臨床開發策略範疇擴展到現有B細胞標靶療法之外。 本白皮書探討了在各類治療方法邁入臨床研究階段之後，委託方需要制定的早期開發決策，內容涵蓋多個主題，涉及首項人體試驗受試人群的選擇、藥效動力學和安全性終點的界定、劑量遞增策略的制定，以及評估健康志願者研究模式、純患者研究模式，亦或混合研究模式何者最為合適。 此外，本文剖析了籃式試驗如何為多種自體免疫疾病的藥物研發提供支持，並凸顯試驗設計需與作用機制、疾病生物學、預計B細胞去除程度以及潛在免疫相關...

NEW YORK--(BUSINESS WIRE)--Tradeweb Markets Inc. (Nasdaq: TW), a global leader in electronic trading across asset classes, today reported financial results for the quarter ended June 30, 2026. $558.9 million quarterly revenues, an increase of 9.0% (8.3% on a constant currency basis) compared to prior year period $245.1 million quarterly international revenues, an increase of 13.9% (12.3% on a constant current basis) compared to prior year period $3.0 trillion average daily volume (“ADV”) for th...

NEW YORK--(BUSINESS WIRE)--Blackstone Mortgage Trust, Inc. (NYSE: BXMT) today reported its second-quarter 2026 results. The net loss attributable to Blackstone Mortgage Trust for the quarter was $81.2 million. Second-quarter EPS, Distributable EPS, Distributable EPS prior to realized gains and losses, and dividends paid per basic share were $(0.48), $0.31, $0.48, and $0.47 respectively. Tim Johnson, Chief Executive Officer said, “BXMT’s second quarter results reflect continued execution of our...

LOUISVILLE, Ky.--(BUSINESS WIRE)--Yum! Brands, Inc. (NYSE: YUM) today reported results for the second quarter ended June 30, 2026. Second-quarter GAAP EPS was $3.08 and second-quarter EPS excluding Special Items was $1.62. CHRIS TURNER COMMENTS Chris Turner, CEO, said “We delivered another strong quarter with robust same-store sales and restaurant-level margin performance. We also reached separate definitive agreements with two exceptional buyers for the Pizza Hut business, bringing our strateg...

RICHMOND, Va.--(BUSINESS WIRE)--Altria Reports 2026 Second-Quarter and First-Half Results; Narrows 2026 Full-Year Earnings Guidance...

MELVILLE, N.Y.--(BUSINESS WIRE)--Henry Schein, Inc. (Nasdaq: HSIC) announced today that it is creating the Henry Schein Leadership Team (HSLT) to replace its Executive Management Committee. The Company will also integrate its global supply chain organization with its global distribution group. The new leadership structure will continue to develop the Company’s strategic priorities, accelerate its execution, and enhance enterprise collaboration. “I am pleased to announce a new leadership structu...

ORLANDO, Fla.--(BUSINESS WIRE)--Hilton Grand Vacations Inc. (NYSE: HGV) (“HGV” or “the Company”) today reports its second quarter 2026 results. Second Quarter 2026 Results1 Total contract sales were $810 million. Total revenues were $1.358 billion. Total revenues were affected by a net construction deferral of $54 million. Net income attributable to stockholders was $12 million and diluted EPS was $0.15. Adjusted net income attributable to stockholders was $72 million and adjusted diluted EPS w...

FORT LAUDERDALE, Fla.--(BUSINESS WIRE)--Auxis, a leading business modernization and nearshore outsourcing provider and part of Grant Thornton Advisors LLC and its multinational platform, today announced the opening of a new knowledge process outsourcing (KPO) center in Bogotá, Colombia. The move strengthens Auxis’ ability to help organizations scale AI-enabled transformation and increasingly complex business operations while creating hundreds of career opportunities in one of Latin America's la...