EMERYVILLE, Calif.--(BUSINESS WIRE)--Eureka Therapeutics, Inc., a clinical stage biopharmaceutical company with the goal of curing cancer by developing novel T-cell therapies that harness the evolutionary power of the immune system, announced today that five abstracts, including four oral presentations and one poster discussion, highlighting clinical programs in multiple myeloma and NHL using binding domains developed by Eureka, have been accepted for presentation at the American Society of Hematology (ASH) Annual Meeting being held December 1-4 in San Diego, California.
The data presented at this meeting underscores the potential potency of antibodies generated from Eureka’s proprietary E-ALPHA discovery platform, which includes the human BCMA and CD19 binding domains used in the CAR-T and ARTEMIS T-cell therapies presented at ASH. The E-ALPHA platform comprises a highly diverse human-derived antibody phage library, containing over 100 billion clones with unique antibody sequences, and a robust workflow to develop highly specific antibodies against target antigens.
“We are pleased to be working with Eureka on our multiple myeloma programs,” said Eric Smith, M.D., Ph.D., Director of Translational Development, Cellular Therapeutics Center at Memorial Sloan Kettering Cancer Center (MSK) and co-inventor of CARs for the targeting of multiple myeloma. “Working with Eureka to identify fully-human BCMA and other multiple myeloma targeted binding domains has the potential to avoid host anti-CAR immunity that may develop when using murine derived antibodies as binders. We look forward to continue working with Eureka on developing the next generation of T-cell therapies.”
“We are delighted that data involving Eureka’s assets are being reported in many presentations at ASH - in particular the exciting clinical data from the BCMA/multiple myeloma programs that we developed in collaboration with Memorial Sloan Kettering in 2012 and licensed to Juno Therapeutics (now Celgene) in 2016,” said Dr. Cheng Liu, President and Chief Executive Officer of Eureka Therapeutics. “In addition, the updated data from the 21-patient proof-of-concept study of our ARTEMIS T-cell therapy (ET190L1 ARTEMIS) for CD19-positive r/r NHL continues to show that our ARTEMIS T-cells have been well tolerated with no observed cytokine release syndrome (CRS) or neurotoxicity, validating the potential of our ARTEMIS platform to deliver safer T-cell therapy than the currently available CAR-T therapies.”
The accepted abstracts are listed below and are now available on the ASH website.
Multiple Myeloma
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CAR T Cell Therapy Targeting G Protein-Coupled Receptor Class C
Group 5 Member D (GPRC5D), a Novel Target for the Immunotherapy of
Multiple Myeloma
Author: Eric L. Smith, MD, PhD
Abstract #589
Oral Session: 652. Myeloma: Pathophysiology and Pre-Clinical Studies, excluding Therapy: Development of Novel Immunotherapeutic Approaches in Multiple Myeloma
Monday, December 3, 2018: 7:00 AM, Ballroom 20D
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Clinical Responses and Pharmacokinetics of MCARH171, a
Human-Derived BCMA Targeted CAR T Cell Therapy in Relapsed/Refractory
Multiple Myeloma: Final Results of a Phase I Clinical Trial
Author: Sham Mailankody, MBBS
Abstract #959
Oral Session: 653. Myeloma: Therapy, excluding Transplantation: Immunotherapies in Plasma Cell Disorders
Monday, December 3, 2018: 5:30 PM, Ballroom 20A
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JCARH125, Anti-BCMA CAR T-cell Therapy for Relapsed/Refractory
Multiple Myeloma: Initial Proof of Concept Results from a Phase 1/2
Multicenter Study (EVOLVE)
Author: Sham Mailankody, MBBS
Abstract #957
Oral Session: 653. Myeloma: Therapy, excluding Transplantation: Immunotherapies in Plasma Cell Disorders
Monday, December 3, 2018: 5:00 PM, Ballroom 20A
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Fully Human BCMA Targeted Chimeric Antigen Receptor T Cells
Administered in a Defined Composition Demonstrate Potency at Low Doses
in Advanced Stage High Risk Multiple Myeloma
Author: Damian J. Green, MD
Abstract #1011
Oral Session: 653. Myeloma: Therapy, excluding Transplantation: Immunotherapy
Monday, December 3, 2018: 6:45 PM, Ballroom 20D
Non-Hodgkin Lymphoma
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ET190L1-ARTEMIS™ T Cell Therapy Results in Durable Disease
Remissions with No Cytokine Release Syndrome or Neurotoxicity in
Patients with Relapsed and Refractory B-Cell Lymphoma
Author: Zhitao Ying, MD, PhD
Abstract #1689
Poster Session: 626. Aggressive Lymphoma (Diffuse Large B-Cell and Other Aggressive B-Cell Non-Hodgkin Lymphomas)—Results from Prospective Clinical Trials: Poster I
Saturday, December 1, 2018, 6:15 PM-8:15 PM, Hall GH
About E-ALPHA® Antibody Discovery Platform
Eureka’s
proprietary E-ALPHA® antibody discovery platform is composed
of a highly diverse human-derived antibody phage library, containing
over 100 billion clones with unique antibody sequences, and a robust
workflow with specificity screens designed to develop highly specific
antibodies against target antigens. The E-ALPHA® platform is
designed to enable Eureka to rapidly discover, iterate upon and improve
our antibodies. Eureka’s E-ALPHA® platform enables Eureka to
develop highly specific antibodies for both conventional targets, such
as cell surface markets, and T-cell receptor targets, such as
intracellular peptides displayed by the major histocompatibility
complex, with the goal of addressing solid tumors.
About ARTEMIS™ T-cell Receptor Platform
Eureka’s proprietary
ARTEMIS™ T-cell receptor platform was designed to create potentially
safer and more effective T-cell therapies. In pre-clinical studies
against CD19-positive malignancies, Eureka’s ARTEMIS™ T-cells matched
the cancer killing potency of currently available CAR-T therapies but
with a dramatic reduction in the levels of inflammatory cytokines
released. Cytokine release syndrome (CRS) and neurotoxicity are serious
side effects associated with currently available CAR-T therapies.
About Eureka Therapeutics, Inc.
Eureka Therapeutics, Inc. is
a privately held clinical stage biopharmaceutical company focused on
developing novel T-cell therapies that harness the evolutionary power of
the immune system. Its core technology centers around its proprietary
ARTEMIS™ T-cell receptor platform and E-ALPHA® antibody
discovery platform for the discovery and development of potentially
safer and more effective T-cell therapies for the treatment of multiple
solid and hematologic tumors.
Eureka Therapeutics, Inc. is headquartered in the San Francisco Bay Area. For more information on Eureka, please visit www.eurekatherapeutics.com.