DURHAM, N.C.--(BUSINESS WIRE)--GeneCentric Therapeutics announced today that it will present the first data on the application of its proprietary Cancer Subtyping Platform (CSP®) to bladder cancer and its potential utility to provide drug response biomarkers for the disease. The gene expression subtyping data will be presented in a poster session at the annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago, IL on June 2, 2018.
“Gene expression subtypes of bladder cancer have shown considerable potential as drug response biomarkers,” said Dr. Myla Lai-Goldman, CEO/Founder of GeneCentric and senior author on the study. “However, to date subtype signatures have required data on several thousand genes, limiting their use to research settings. This research demonstrates that by applying our CSP platform, subtypes can be generated with a 60-gene signature Cancer Profiler, opening the door to broad use in drug development and ultimately, clinical practice.” She noted that with an estimated 81,190 new bladder cancer cases in the US and 17,240 deaths, and the emergence of promising immuno and targeted therapies, there is a significant need for biomarkers predictive of drug response.
The studies, conducted by GeneCentric scientists in collaboration with researchers at the University of North Carolina Chapel Hill’s Lineberger Cancer Center, assigned four gene expression subtypes based on approximately 2700 genes from 408 bladder cancer patients in The Cancer Genome Atlas (TCGA). The researchers then developed a subtype signature based on 60 genes and tested the 60-gene set in two additional data sets.
Analysis of the gene signatures suggested additional study of their potential as therapeutic biomarkers independently as well as in combination with other molecular features. For example, subtypes showed differences in the expression profiles of genes that are promising therapeutic targets in bladder cancer, such as FGFR3 and ERBB2. The differences were consistent across multiple data sets. Bladder cancer subtypes also showed variability in immune profiles that is likely to inform the response to immunotherapy. Subtypes were also found to be significantly prognostic for Stage 2 and 3 bladder cancer.
Details of the presentation are as follows:
Title: “Bladder Cancer Gene Expression Subtypes (60 gene
signature) Defines Prognosis, Differential Immune Response and Biomarker
Abstract Number: 4538
Date: June 2, 2018
Location: Hall A
Presenter: Greg Mayhew, PhD, Director, Bioinformatics, GeneCentric Therapeutics
To read the abstract, please visit: https://meetinglibrary.asco.org/record/160438/abstract
GeneCentric Therapeutics is applying proprietary technology to identify drug responder populations that enable development of precision medicine drugs and improve patient outcomes. Our approach applies the Cancer Subtype Platform (CSP®) to parse complex tumor biology into genomic signatures revealing high-resolution cancer subtypes, with potential as universal biomarkers for susceptibility to multiple classes of agents including immune-based, molecularly targeted and chemotherapeutics. We are commercializing our technology through strategic collaborations with pharmaceutical and biotech companies to define responder populations applicable throughout the drug development cycle. In addition to bladder cancer, GeneCentric has developed gene expression based Cancer Profilers for lung, and head and neck cancer. GeneCentric has established several pharmaceutical collaborations, including an alliance with Bristol Myers Squibb in immuno-oncology. For more information, please visit www.genecentric.com.