CAMBRIDGE, Mass.--(BUSINESS WIRE)--EnBiotix, Inc., a product-focused bioengineering company leveraging systems and synthetic biology platforms to combat the global rise of drug-resistant and drug-tolerant bacterial infections, announced today a publication in Antimicrobial Agents & Chemotherapy , a journal of the American Society for Microbiology, detailing data on EBX-001, the Company’s lead product for the treatment of Pseudomonas aeruginosa infections. The paper titled, “An Anti-Persister Strategy for the Treatment of Chronic Pseudomonas aeruginosa Infections,” was co-authored by a team of scientists from Massachusetts General Hospital, Harvard Medical School, the Geisel School of Medicine at Dartmouth and EnBiotix.
“EnBiotix’s anti-persister platform combines current standard-of-care therapeutics with potentiator molecules to significantly enhance the eradication of persistent drug-tolerant bacteria,” commented Diane Joseph-McCarthy, Ph.D., Vice President of Translational Science at EnBiotix. “The publication describes translational work related to our lead program, EBX-001, on the combination of tobramycin with an anti-bacterial potentiator for the treatment of chronic, recurrent Pseudomonas infections. We look forward to further development of this program.”
Jeffrey D. Wager, M.D., Chairman and CEO of EnBiotix, added, “It is deeply motivating for us at EnBiotix to realize we could offer a substantial therapeutic option to address cystic fibrosis and other serious antibiotic-tolerant infections with this therapy. The results reported in the AAC publication present significant promise for further development of anti-persister treatments, and we are excited to do so with EBX-001 for these indications.”
EnBiotix’s Anti-persister Platform
In response to a variety
of stresses including antibiotic treatment, bacteria can enter into a
persistent or quasi-dormant state in which they are unresponsive or
tolerant to antibiotic treatment. Bacteria in this persistent state are
responsible for serious, recurrent infections associated with high
morbidity and mortality. EnBiotix’s anti-persister platform utilizes a
potentiator molecule to stimulate persisters metabolically to enable
uptake of and killing by aminoglycoside antibiotics. Our lead program,
EBX-001, combines tobramycin with a metabolite potentiator as a novel
inhaled treatment, with broad IP coverage covering the product
combination and the indication. In addition to EBX-001, EnBiotix has
other combinations in its pipeline that are being developed for the
treatment of a variety of Gram-negative infections.
About EnBiotix
EnBiotix is an engineered antibiotics company
deploying novel systems and synthetic biology technologies developed by
Prof. James J. Collins, the Termeer Professor of Medical Engineering &
Science Professor, Department of Biological Engineering, Massachusetts
Institute of Technology. These technologies enable the development of
both novel antibiotics and potentiators of existing antibiotics which
have the potential to transform their spectrum of activity and
resistance profile. With drug-resistant and drug-tolerant infections
rapidly becoming a global health crisis, EnBiotix’s robust product
pipeline addresses a wide range of acute and chronic infections to
significantly impact the lives of patients. www.enbiotix.com
