Eli Lilly and Company Introduces Reconcile for Separation Anxiety in Dogs

At-Home BOND Behavior Modification Training Plan Complements Drugs Efficacy

INDIANAPOLIS--()--Eli Lilly and Company (NYSE: LLY) announced today it has received approval from the FDA to market Reconcile (fluoxetine hydrochloride), the first selective serotonin reuptake inhibitor (SSRI) class of antidepressants approved by the FDA for treatment of canine separation anxiety in conjunction with behavior modification training. Reconcile is the first Lilly product approved by the FDA for dogs and is now available to U.S. veterinarians.

Lilly research shows that 10.7 million, or up to 17 percent of U.S. dogs1 suffer from separation anxiety, said Steve Connell, D.V.M., manager of technical, academic and consumer services for companion animal health at Lilly. Were thrilled that our first product for dogs can help restore the human-pet bond, which can be compromised when dogs suffer from separation anxiety."

Reconcile is a once-daily, chewable, flavored tablet that may be prescribed by a veterinarian in weight-specific doses for use in conjunction with behavior modification training to treat canine separation anxiety. The drug is proven safe for dogs and puppies six months or older.

In field studies of approximately 600 dogs, 73 percent of dogs receiving Reconcile showed improvement in separation anxiety-related behavior within eight weeks when compared with dogs receiving behavior modification training alone. Within one week of starting Reconcile treatment and behavior modification training, 42 percent of dogs showed improvement. During trials, the most common adverse reactions to Reconcile were calm or lethargy, reduced appetite, vomiting, shaking, diarrhea, restlessness, excessive vocalization, aggression and in infrequent cases seizures.

Reconcile allows dogs to be more receptive to your training to help with anxiety

Canine separation anxiety is a prevalent and often misunderstood behavior problem, according to Connell. It amounts to undesirable behavior that occurs when the dog is left alone even for short periods of time. The resulting anxiety may cause the dog to engage in inappropriate behavior, such as destruction, excess vocalization and inappropriate elimination. Anorexia and depression also may be observed in some cases. Your family veterinarian may recommend certain tests before diagnosing separation anxiety, Connell added. Such tests are used to rule out other potential physiological causes of inappropriate behavior.

For dogs affected by separation anxiety, Reconcile reduces inappropriate behaviors, minimizes the pets distress and increases receptivity to a simple training plan called the BOND modification training plan.

The BOND behavior modification program is an easy-to-implement, at-home training plan developed by Lilly and a team of veterinary behaviorists as well as veterinarians. The simple plan allows dog owners to take an active role in the treatment of their pets separation anxiety to help restore the human-pet bond. Dog owners whose veterinarians have prescribed Reconcile receive educational materials to enable them to follow an easy four-step training plan to reinforce positive pet behavior which helps to reduce or eliminate inappropriate responses to anxiety. Components include a take-home DVD, printed materials and in-home reminders so the whole family can reinforce behavior modification training for the dog.

Debra F. Horwitz, D.V.M., and a diplomate of the American College of Veterinary Behaviorists, was among the veterinary behaviorists involved in developing the BOND program. Learning and memory are important in the formation and maintenance of anxieties, said Horwitz. Decreasing anxiety can help pets learn and, through training, they can learn new responses to stimuli that have triggered separation anxiety in the past. The development of the BOND behavior modification plan is an important complement to Reconcile in the treatment of separation anxiety.

For more information about Reconcile and the BOND behavior modification program, which are available only through veterinarians, visit www.reconcile.com. Important safety information and the product label also can be found at www.reconcile.com.

Lilly, a leading innovation-driven corporation, is developing a growing portfolio of first-in-class and best-in-class pharmaceutical products by applying the latest research from its own worldwide laboratories and from collaborations with eminent scientific organizations. Headquartered in Indianapolis, Lilly provides answers through medicines and information for some of the worlds most urgent medical needs. Additional information about Lilly is available at www.lilly.com. Information about Lilly products for pets is available at www.lillypet.com.

Reconcile and BOND are registered trademarks of Eli Lilly and Company.

1 Lilly Research 2006

Contacts

Eli Lilly and Company
Joan Todd, 317-433-0121
or
McCormick Co.
John Dutcher, 515-238-5051

Contacts

Eli Lilly and Company
Joan Todd, 317-433-0121
or
McCormick Co.
John Dutcher, 515-238-5051