DUBLIN--(BUSINESS WIRE)--The "Diagnostic Pathology: Molecular Oncology. Edition No. 2" book has been added to ResearchAndMarkets.com's offering.
Covering all aspects of molecular pathology as it relates to the transformation and pathogenesis of cancer, this award-winning volume in the Diagnostic Pathology series is an expert resource for pathologists at all levels of experience and training, both as a quick reference and as an efficient review to improve knowledge and skills. This easily accessible, point-of-care reference features templated, bulleted content that is generously illustrated with charts, graphs, tables, and color photomicrographs of histology with special stains. It offers a practical, clinical approach to examining how molecular mutations affect common medical diseases and identifies the relevant and appropriate molecular tests to perform for a complete work-up in the era of molecular-targeted therapies.
Key Topics Covered:
- DP2 Molecular Oncology: Auerbach and Vasef
- Introduction
- Structure of Chromosomes and Nucleic Acids
- DNA Replication, Transcription, and Translation
- Gene Mutations
- Common Techniques for Analysis of Alterations in Chromosomes and DNA
- Cytogenetics and FISH
- Chromosomal Microarray
- Amplification Methods
- DNA High-Resolution Melting Curve Analysis
- Sequencing Technologies
- High-Throughput Methods in Molecular Pathology
- DNA Methylation Analysis
- Molecular Genetic Tests in Hematopoietic Tumors
*BCR-ABL1* Fusion Gene
*PDGFRA*, *PDGFRB*, and *FGFR1* Rearrangements Detection
- PML-RARA Fusion Gene
- Reverse Transcription PCR for Other Myeloid Leukemia Transcripts
- FLT3, NPM1, and CEBPA Mutations
- JAK2 Mutations and Rearrangements
- MPL Mutations
- Calreticulin (CALR) Mutations
- CSF3R Mutations
- SETBP1 Mutations
- KIT Mutations
- IDH1 and IDH2 Mutations
- Other Mutations and Gene Panel Testing in Myeloid Neoplasms
- Immunoglobulin Heavy (IGH) Chain Gene Rearrangements
- T-Cell Receptor Gamma (TRG) and Delta (TRD) Chain Rearrangements
- T-Cell Receptor Beta (TRB) Chain Gene Rearrangements
- Southern Blot Analysis of Antigen Receptor Genes
- EBV-Associated Human Neoplasms
- MYD88 Mutation
- NOTCH1 Mutation
- EZH2 Mutation
- Molecular Genetic Tests in Solid Tumors, Bone and Soft Tissue Tumors, and CNS Tumors
- ALK Gene Rearrangements and Mutations
- FISH for ROS1 Rearrangements
- RET Rearrangements
- FISH for MET Amplifications
- FISH for ERBB2 (HER2) Gene Amplifications
- KRAS Mutations
- BRAF Mutations
- EGFR Mutations
- Targeted Hotspot Gene Panel Using Massively Parallel Sequencing (Next Generation Sequencing)
- Targeted Hotspot Gene Panel Table
- MGMT Promoter Gene Methylation Assay
- MET Exon 14 Skip Mutations
- NGS Panels for NCI MATCH
- FISH for 1p/19q Deletions
- IDH1 and IDH2 Mutations
- Molecular Basis of Immunotherapy in Cancer
- Molecular Pathology of Myeloid Neoplasms
- Molecular Pathology of Myeloid Neoplasms
- Molecular Work-Up of Myeloid Neoplasms
- Myeloproliferative Neoplasms
- Chronic Myeloid Leukemia, BCR-ABL1 Positive
- Chronic Neutrophilic Leukemia
- Polycythemia Vera
- Primary Myelofibrosis
- Essential Thrombocythemia
- Chronic Eosinophilic Leukemia, NOS
- Mastocytosis
- Myeloproliferative Neoplasms, Unclassifiable
- Mastocytosis
- Myeloid/Lymphoid Neoplasms With PDGFRA Rearrangement
- Myeloid/Lymphoid Neoplasms With PDGFRB Rearrangement
- Myeloid/Lymphoid Neoplasms With FGFR1 Rearrangement
- Myeloid/Lymphoid Neoplasms With PCM1-JAK2
- Myelodysplastic Syndrome (MDS)
- Acute Myeloid Leukemia
- Myeloid Sarcoma
- Acute Leukemias of Ambiguous Lineage
- Overview of Ambiguous Lineage Leukemias
- Acute Undifferentiated and Mixed Phenotype Acute Leukemias
- Molecular Pathology of Lymphoid Neoplasms
- Overview of Lymphoid Neoplasms
- Molecular Work-Up of Lymphoid Neoplasms
- Precursor Lymphoid Neoplasms
- B-Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified
- B-Lymphoblastic Leukemia/Lymphoma With Recurrent Genetic Abnormalities
- B-Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like
- T-Lymphoblastic Leukemia/Lymphoma
- Mature B-Cell Neoplasms
- Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia
- Monoclonal B-Cell Lymphocytosis
- B-Cell Prolymphocytic Leukemia
- Splenic Marginal Zone Lymphoma
- Hairy Cell Leukemia
- Splenic B-Cell Lymphoma/Leukemia, Unclassifiable
- Lymphoplasmacytic Lymphoma
- IgM Monoclonal Gammopathy of Undetermined Significance
- Heavy Chain Disease
- Plasma Cell Myeloma
- Marginal Zone Lymphoma
- Follicular Lymphoma
- Large B-Cell Lymphoma With IRF4 Rearrangement
- Mantle Cell Lymphoma
- Diffuse Large B-Cell Lymphoma
- T-Cell/Histiocyte-Rich Large B-Cell Lymphoma
- Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation
- Burkitt Lymphoma
- High-Grade B-Cell Lymphoma
- Mature T- and NK-Cell Neoplasms
- T-Cell Prolymphocytic Leukemia
- Chronic Lymphoproliferative Disorder of NK Cells
- Aggressive NK-Cell Leukemia
- Extranodal NK-/T-Cell Lymphoma, Nasal Type
- Adult T-Cell Leukemia/Lymphoma
- Intestinal T-Cell Lymphoma
- Hepatosplenic T-Cell Lymphoma
- Subcutaneous Panniculitis-Like T-Cell Lymphoma
- Mycosis Fungoides/Sezary Syndrome
- Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders
- Primary Cutaneous Peripheral T-Cell Lymphoma, Rare Subtypes
- Peripheral T-Cell Lymphoma, Not Otherwise Specified
- Angioimmunoblastic T-Cell Lymphoma
- Anaplastic Large Cell Lymphoma, ALK-Negative
- Anaplastic Large Cell Lymphoma, ALK-Positive
- Breast Implant-Associated Anaplastic Large Cell Lymphoma
- Determination of Clonality in B-, T-, and NK-Cell Neoplasms
- Lymphoma-Associated Chromosomal Translocations
- Molecular Pathology of Dendritic Cell and Histiocytic Neoplasms
- Histiocytic Sarcoma
- Tumors Derived From Langerhans Cells
- Interdigitating Dendritic Cell Tumor
- Interdigitating Dendritic Cell Sarcoma
- Follicular Dendritic Cell Neoplasm
- Fibroblastic Reticular Cell Tumor
- Disseminated Juvenile Xanthogranuloma
- Erdheim-Chester Disease
- Molecular Pathology of Solid Tumors
- Head and Neck, Including Sinonasal Tumors and Salivary Glands
- HPV-Related Squamous Cell Carcinoma
- Head and Neck Mucosal Squamous Cell Carcinoma, Non-HPV-Related
- Important Alterations in Non-HPV-Related Head & Neck SCC
- Translocation-Specific Salivary Gland Tumors
- Nasopharyngeal EBV-Related Squamous Carcinoma
- Other Head and Neck Tumors
- Thyroid
- Lung
- Liver
- Testis
- Kidney
- Bladder
- Breast
- Cervix/Vulva/Vagina
- Uterus
- Ovaries/Fallopian Tube
- Skin
- Preneoplastic Conditions, Skin
- Melanoma
- Squamous Cell Carcinoma, Skin
- Basal Cell Carcinoma, Skin
- Other Skin Conditions
- Bone
- Soft Tissue
- Overview
- Intermediate and Malignant Myofibroblastic/Fibroblastic Tumors
- Liposarcomas
- Muscle Sarcomas
- Intermediate and Malignant Vascular Tumors
- Malignant Peripheral Nerve Sheath Tumor
- Representative Genetic Findings in Bone and Soft Tissue Tumors
- Sarcomas of Uncertain Differentiation
- Rare Sarcomas of Uncertain Differentiation With Specific Molecular Alterations
- CNS
- High-Grade Astrocytoma
- Low-Grade Astrocytoma
- Pilocytic Astrocytoma
- Oligodendroglioma
- Ependymoma
- Medulloblastoma
- Choroid Plexus Tumors
- Meningioma
- Retinoblastoma
- Quality Assurance and Regulatory Issues
- Federal Agencies and Regulation of Laboratories
- FDA Regulations
- Proficiency Testing and Accreditation
Authors
- Vasef, Mohammad A. Professor of Pathology, The University of New Mexico Health Sciences Center, Albuquerque, New Mexico.
- Auerbach, Aaron Staff Pathologist, Department of Hematopathology, The Joint Pathology Center, Bethesda, Maryland.
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