CLSI's Publishes Annually Updated AST Supplement M100 with Standards M02 and M07

Published by the Clinical and Laboratory Standards Institute

WAYNE, Pa.--(BUSINESS WIRE)--The Clinical and Laboratory Standards Institute announces the publication of its annually updated antimicrobial susceptibility testing (AST) supplement M100—Performance Standards for Antimicrobial Susceptibility Testing, 28th ed., as well as its associated methodology standards M02—Performance Standards for Antimicrobial Disk Susceptibility, 13^th ed. And M07—Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically, 11^th ed. This year M100 is available as part of a package with either M02 or M07, or all three documents together.

M02 covers the current recommended methods for disk susceptibility testing and criteria for quality control testing, and includes the M02 Quick Guide. M07 covers reference methods for determining minimal inhibitory concentrations of aerobic bacteria by broth macrodilution, broth microdilution, and agar dilution. M100 includes annually updated tables for M02, M07, and M11.

M100, 28^th ed. Includes:

• Revised organism nomenclature.
• Breakpoint additions and revisions.
• Expansion of the MCIM test for detection of metallo beta-lactamases.

M02, 13^th ed. Includes:

• Clarified definitions for breakpoint, interpretive category, and susceptible.
• Reorganized and clarified information for staphylococci.
• Current recommended methods for disk susceptibility testing and criteria for quality control testing.

M07, 11^th ed. Includes:

• Photographs of growth control examples and interpretation of skipped wells.
• Reference methods for determining minimal inhibitory concentrations of aerobic bacteria.

Some highlights for 2018 include the addition of breakpoints for ceftazidime-avibactam and dalbavancin, expansion of the mCIM test for detection of metallo beta-lactamases, and new tables and expanded recommendations for QC of beta-lactam combination agents.

On February 7 and February 8, 2018, CLSI will host the Annual AST Updates Webinar (clsi.org/ast2018). This webinar, “CLSI 2018 AST Webinar: M100, M02, and M07 Updates,” focuses on changes and updates to these documents, followed by a question and answer session. To register, visit clsi.org/ast2018.