SAN ANTONIO--(BUSINESS WIRE)--Significant developments in breast cancer research will be presented by NantHealth (NASDAQ: NH) at the San Antonio Breast Cancer Symposium this week. NantHealth, a leader in breakthrough cancer research and solutions to improve patient care and lower healthcare costs, will discuss the findings of three investigations, which examine the theme of providing oncologists with insights that enable cancer treatment tailored to the individual characteristics of each patient.
The Symposium, which will be held at the Henry B. Gonzalez Convention Center in San Antonio from Dec. 4-8, is designed to provide state-of-the-art information on the experimental biology, etiology, prevention, diagnosis and therapy of breast cancer and premalignant breast disease, to an international audience of academic and private physicians and researchers.
“About 1 in 8 U.S. women or about 12.4% will develop invasive breast cancer over the course of her lifetime. Such staggering statistics make breast cancer research and progress critical,” said Sandeep “Bobby” Reddy MD, Chief Medical Officer, NantHealth. “We are honored to have an integral role at the San Antonio Breast Cancer Symposium, which provides a dynamic forum for interaction, communication, and education for a broad spectrum of researchers, health professionals, and those with a special interest in breast cancer.”
Title: “Germline potentially pathogenic variants in breast cancer
intrinsic molecular subtypes are not associated with somatic TMB”
Presenting
Author: Elias Obeid, MD, MPH
Senior Author: Christopher
Szeto, PhD
Contributors: Sandeep “Bobby” Reddy MD; Lori J.
Goldstein, MD; Mary B. Daly, MD, PhD; Stephen C. Benz, PhD; and Michael
J. Hall, MD, MS
Description: Comprehensive DNA and RNA
profiling of 270 patients revealed intrinsic molecular subtypes of
breast cancer have significantly distinct profiles of pathogenic
germline variants. However, despite some breast cancer subtypes having
higher frequency of germline pathogenic variants within DNA-damage
repair genes, there is little evidence that these patients have
subsequently higher mutational burden within their somatic genomes.
Key
Takeaway: Pathogenic germline variants in key DNA damage repair
genes such as BRCA1/2 are likely not adequate biomarkers for immune
checkpoint therapy response, but are potentially biomarkers of
differential tumorigenesis pathways.
Title: “Time-course DNA and RNA profiling of tumors from
intra-patient cross-over trial of sequential use of aromatase inhibitors”
Presenting
Author: Charles Vaske
Senior Authors: Vessela Kristensen
and Jürgen Geisler
Contributors: Rahul Parulkar, Nazli
Bahrami, Torill Sauer, Marie Loeng, Berit Gravdehaug, Belal Aljabri,
Vahid Bemanian, Jonas Lindstrøm and Torben Lüders
Description:
Early analysis from the ongoing NEOLETEXE trial examines a time-series
of biopsies taken while transitioning patients from steroidal to
non-steroidal aromatase inhibitors (AI) and vice versa. Acquired markers
of AI-therapy resistance, and potential markers of sequential therapy
sensitization, were explored. Two months after initial therapy,
mutational burden decreased and clonality increased, yet by 4mo
post-initialization mutations particularly in PIK3CA had repopulated.
Key
Takeaway: Switching AI therapies sequentially in a clinical study is
a model system to study differences in anti-tumor-effects of AIs. This
ongoing trial may lead to a novel strategy to resensitize tumors to
hormonal treatment and to elucidate the differences between steroidal
and non-steroidal AIs.
Title: “Identification of a neoantigen targeted by
tumor-infiltrating lymphocytes in a patient with Her2+ breast cancer”
Presenting
Author: Hannah Kranich
Senior Authors: Peter A. Fasching
and Anita N. Kremer
Contributors: Andrew Nguyen, Hanna
Hübner, Erber Ramona, Judith Bausenwein, Edith D. van der Meijden,
Michael P. Lux, Sebastian Jud, Claudia Rauh, John Zachary Sanborn,
Stephen C. Benz, Shahrooz Rabizadeh, Matthias W. Beckmann, Andreas
Mackensen and Matthias Rübner
Description: In our study, we
identify tumor infiltrating T-cells (TILS) that recognize tumor specific
mutations (Neoepitopes) found by next-generation sequencing of breast
cancer tumors. These identified TILS are further immortalized and
characterized to bind the patient’s specific HLA alleles.
Key
Takeaway: Identification of TILS recognizing patient specific
neoepitopes allow development of personalized medicine in a pre-clinical
setting.
Since 1977, the San Antonio Breast Cancer Symposium mission has been to provide state-of-the-art information on breast cancer research. From a one-day regional conference, the Symposium has grown to a five-day program attended by a broad international audience of academic and private researchers and physicians from over 90 countries. For more information visit: https://www.sabcs.org/2018-SABCS-sup-sup.
About NantHealth
NantHealth, Inc., a member of the NantWorks ecosystem of companies, uses personalized data to improve patient care and lower healthcare costs. NantHealth leads the way in providing oncologists with insights that enable cancer treatment tailored to the individual characteristics of each patient. NantHealth solutions reduce the cost of care by connecting patient data and streamlining the accurate collection and sharing of that data--starting from a patient’s bedside, extending to payers and providers. NantHealth improves clinical decision support, eliminates unwarranted care and seeks to enhance. For more information please visit www.nanthealth.com.
About NantOmics
NantOmics, a member of the NantWorks ecosystem of companies, delivers molecular analysis capabilities with the intent of providing actionable intelligence and molecularly driven decision support for cancer patients and their providers at the point of care. NantOmics is the first molecular analysis company to pioneer an integrated approach to unearthing the genomic variants and transcriptomic changes that initiate and drive cancer, by analyzing both normal and tumor cells from the same patient and connecting drugs to DNA to RNA changes in the tumor. NantOmics has a highly scalable cloud-based infrastructure capable of storing and processing thousands of genomes a day. For more information please visit www.nantomics.com.