The market study covers the present scenario and growth prospects of the global rabies treatment market for 2017-2021. The report also lists pre-exposure prophylaxis and post-exposure prophylaxis as the two major application segments.
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Technavio analysts highlight the following three market drivers that are contributing to the growth of the global rabies treatment market:
- The need for contamination-free vaccines with novel culture media
- Growing issue of stray animals in developing economies
- Novel routes of administration
The need for contamination-free vaccines with novel culture media
Vaccines currently available for human use are cultured using formulations containing human or animal components. To eradicate the risk of contamination of vaccines by BSE agents or human components, vendors are focusing on the development of novel vaccine production medias that are free from animal and human components. For instance, Sanofi is developing an enhanced version of PVRV-NG, which is free from bovine serum and fetal tissue. This next-generation vaccine contains inactivated Pitman-Moore strain of rabies virus, which is common to currently available vaccines like Imovax and Verorab.
“The continuous efforts by vendors to manufacture contamination-free vaccines with novel culture media along with strict regulatory checks by the government are likely to drive market growth in terms of both value and volume,” says Sapna Jha, a lead analyst at Technavio for infectious and rare diseases research.
Growing issue of stray animals in developing economies
Rabies is a zoonotic disorder that is transmitted through the saliva of a rabid animal to humans as well as to other animals. The increasing stray dog population and the absence of effective rabies vaccination programs in developing economies make these regions the major sources of rabies worldwide. As per CDC, 90% of all rabies cases and 99% of rabies-related deaths are due to the exposure to rabid dogs and accounts for more than 99% deaths due to rabies worldwide. Thus, the demand for anti-rabies treatment regimen such as cell culture vaccines (CCVs) and rabies immunoglobulin (RIGs) for post-exposure prophylaxis is high. This increase in the demand for rabies vaccine for post-exposure prophylaxis, is likely to drive market growth in terms of both volume and value.
Novel routes of administration
The high cost of CCVs for intramuscular administration has posed a major challenge for the widespread adoption of these vaccines in developing countries for pre-exposure and post-exposure prophylaxis against rabies. To overcome this hurdle, the WHO recommends the intradermal administration of CCVs for post-exposure prophylaxis of rabies in countries where rabies is prevalent and intramuscular biological for rabies is unavailable and unaffordable. The intradermal vaccine requires only 1-2 doses to complete the full course of post-exposure prophylaxis and helps reduce the volume used and cost of vaccine by at least 55%-65% compared with intramuscular vaccines.
“Intradermal vaccines have similar potency as intramuscular vaccines and provide a safe and immunogenic alternative at a lower cost. Intradermal vaccines have been introduced in developing countries such as India, the Philippines, Sri Lanka, and Thailand. Considering the high prevalence of rabies and the low income of people in these countries, the introduction of cost-effective alternatives is likely to drive the market growth,” says Sapna.
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