DUBLIN--(BUSINESS WIRE)--Research and Markets (http://www.researchandmarkets.com/research/ww2bvb/mtor_signaling) has announced the addition of the "mTOR Signaling Pathway in Oncology Drug Pipeline Update 2013" report to their offering.
The mammalian target of rapamycin (mTOR) is an intracellular kinase that controls the production of proteins through its regulation of translational machinery. mTOR-activated proteins promote several hallmarks of cancer such as cell growth and proliferation, angiogenesis, and bioenergetics.
Since mTOR acts as a neoplastic switch that is frequently turned on by many mutations found in cancer, inhibition of mTOR may offer a promising new strategy for cancer therapy. Given that the mTOR pathway is deregulated in a number of cancers, it is anticipated that mTOR inhibitors will have broad therapeutic application across many tumor types.
There are today 125 companies plus partners developing 176 mTOR signaling pathway targeting drugs in 598 developmental projects in cancer. In addition, there is 1 suspended drug and the accumulated number of ceased drugs over the last years amount to another 52 drugs. Mtor Signaling Pathway In Oncology Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 81 different targets.
All included targets have been cross-referenced for the presence of mutations associated with human cancer. To date 72 out of the 81 studied drug targets so far have been recorded with somatic mutations. The software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information. All drugs targets are further categorized on in the software application by 26 classifications of molecular function and with pathway referrals to BioCarta, KEGG. NCI-Nature and NetPath.
How May Drug Pipeline Update Be of Use?
- Show investors/board/management that you are right on top of drug development progress in your therapeutic area.
- Find competitors, collaborations partners, M&A candidates etc.
- Jump start competitive drug intelligence operations
- Excellent starting point for world wide benchmarking
- Compare portfolio and therapy focus with your peers
- Speed up pro-active in-/out licensing strategy work
- Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug.
For more information visit http://www.researchandmarkets.com/research/ww2bvb/mtor_signaling
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