Pfizer Reports Fourth-Quarter and Full-Year 2012 Results; Provides 2013 Financial Guidance

• Fourth-Quarter 2012 Revenues of $15.1 Billion and Full-Year Revenues of $59.0 Billion, both excluding Discontinued Operations Revenues of $592 Million and $2.3 Billion, Respectively, from the Nutrition⁽¹⁾ Business
• Fourth-Quarter 2012 Adjusted Diluted EPS⁽²⁾ of $0.47, Reported Diluted EPS⁽³⁾ of $0.85; Full-Year 2012 Adjusted Diluted EPS⁽²⁾ of $2.19, Reported Diluted EPS⁽³⁾ of $1.94
• Repurchased $3.4 Billion and $8.2 Billion of Common Stock in Fourth-Quarter and Full-Year 2012, Respectively
• Provides Initial 2013 Financial Guidance; Reflects the Benefit of a Full-Year Contribution from Zoetis⁽⁴⁾, Partially Offset by a $0.02 Unfavorable Impact on Adjusted⁽²⁾ and Reported⁽³⁾ Diluted EPS Guidance for Zoetis⁽⁴⁾-Related Interest Expense and Certain Duplicative and Other Costs Given its Potential Separation

NEW YORK--(BUSINESS WIRE)--Pfizer Inc. (NYSE: PFE):

($ in millions, except per share amounts)
	Fourth-Quarter						Full-Year
		2012		2011^(5)	Change			2012		2011^(5)	Change
Reported Revenues	$	15,068	$	16,141	(7	%)	$	58,986	$	65,259	(10	%)
Adjusted Income^(2)		3,512		3,784	(7	%)		16,476		17,839	(8	%)
Adjusted Diluted EPS^(2)		0.47		0.49	(4	%)		2.19		2.27	(4	%)
Reported Net Income^(3)		6,315		1,439	*			14,570		10,009	46	%
Reported Diluted EPS^(3)		0.85		0.19	*			1.94		1.27	53	%

See end of text prior to tables for notes.

* Calculation not meaningful

Pfizer Inc. (NYSE: PFE) today reported financial results for fourth-quarter and full-year 2012. Fourth-quarter 2012 revenues were $15.1 billion, a decrease of 7% compared with $16.1 billion in the year-ago quarter, which reflects an operational decline of $802 million, or 5%, and the unfavorable impact of foreign exchange of $271 million, or 2%.

For fourth-quarter 2012, U.S. revenues were $5.8 billion, a decrease of 9% compared with the year-ago quarter. This decrease was primarily the result of the loss of exclusivity of Lipitor in November 2011 and Geodon in March 2012. International revenues were $9.3 billion, a decrease of 5% compared with the prior-year quarter, mainly due to the losses of exclusivity of Lipitor in developed Europe during second-quarter 2012 and the unfavorable impact of foreign exchange. U.S. revenues represented 38% of total revenues in fourth-quarter 2012 compared with 39% in the year-ago quarter, while international revenues represented 62% of total revenues in fourth-quarter 2012 compared with 61% in the year-ago quarter.

Full-year 2012 revenues were $59.0 billion, a decrease of 10% compared with $65.3 billion in full-year 2011, which reflects an operational decline of $4.8 billion, or 8%, and the unfavorable impact of foreign exchange of $1.5 billion, or 2%.

For full-year 2012, U.S. revenues were $23.1 billion, a decrease of 14% compared with full-year 2011. This decrease was primarily the result of the aforementioned loss of exclusivity of Lipitor. International revenues were $35.9 billion, a decrease of 6% compared with the prior year, mainly due to the previously mentioned losses of exclusivity of Lipitor and the unfavorable impact of foreign exchange. U.S. revenues represented 39% of total revenues in full-year 2012 compared with 41% in the previous year, while international revenues represented 61% of total revenues in full-year 2012 compared with 59% in full-year 2011.

Fourth-Quarter Revenues^(6)
($ in millions) Favorable/(Unfavorable)	2012		2011		Change		Foreign Exchange		Operational
Primary Care	$	3,833	$	5,411	(29	%)	(1	%)	(28	%)
Specialty Care		3,668		3,820	(4	%)	(2	%)	(2	%)
Emerging Markets		2,652		2,264	17	%	(3	%)	20	%
Established Products		2,370		2,300	3	%	(2	%)	5	%
Oncology		370		341	9	%	(2	%)	11	%
Biopharmaceutical		12,893		14,136	(9	%)	(2	%)	(7	%)
Animal Health		1,171		1,106	6	%	(2	%)	8	%
Consumer Healthcare		936		810	16	%	(1	%)	17	%
Other^(7)		68		89	(24	%)	(1	%)	(23	%)
Total	$	15,068	$	16,141	(7	%)	(2	%)	(5	%)

See end of text prior to tables for notes.

Business Commentary

Primary Care unit revenues decreased 28% operationally in comparison with fourth-quarter 2011, primarily due to the losses of exclusivity of Lipitor in most major markets, as well as the resulting shift in the reporting of U.S. and Japan Lipitor revenues to the Established Products unit beginning January 1, 2012. This decline in revenues for Lipitor and for certain other Primary Care unit products that lost exclusivity in various markets in 2012 and 2011 reduced Primary Care unit revenues by approximately $1.8 billion, or 33%. The impact of this decline was slightly offset by the continued strong operational growth of Lyrica in developed markets as well as Celebrex and Viagra in the U.S.

Specialty Care unit revenues declined 2% operationally in comparison with fourth-quarter 2011. Revenues were positively impacted by growth of the Prevnar/Prevenar franchise, primarily due to the timing of U.S. government purchases, as well as growth of Enbrel and Rebif, mostly in the U.S., in addition to Benefix, ReFacto/Xyntha and Zyvox. This increase was more than offset by approximately $360 million, or 9%, due to product losses of exclusivity.

Emerging Markets unit revenues grew 20% operationally in comparison with fourth-quarter 2011. This growth was primarily driven by strong volume growth in China as a result of more targeted promotional efforts for key innovative and established products, including Lipitor, Norvasc and Sulperazon, and overall market growth, as well as the timing of government purchases of Enbrel in Brazil and Prevenar 13 in Turkey in comparison with the year-ago period.

Established Products unit revenues increased 5% operationally in comparison with the prior-year period, primarily reflecting the inclusion of $200 million of U.S. and Japan branded Lipitor revenues in fourth-quarter 2012. This increase was partially offset by the decline of revenues of certain products that recently lost exclusivity and the impact of ongoing pricing pressures, primarily in developed Europe and South Korea. Total revenues from established products in both the Established Products and Emerging Markets units were $3.5 billion, with $1.1 billion generated in emerging markets.

Oncology unit revenues increased 11% operationally in comparison with fourth-quarter 2011. Revenues were positively impacted by the launches of Inlyta and Xalkori in the U.S. and certain other developed markets. Revenues were negatively impacted by approximately $44 million, or 13%, due to the shift in the reporting of international Aromasin revenues to the Established Products unit beginning January 1, 2012.

Consumer Healthcare unit revenues increased 17% operationally in comparison with fourth-quarter 2011, primarily due to the addition of products from the acquisitions of Ferrosan Consumer Health in December 2011 and Alacer Corp. in February 2012 as well as strong growth of Advil and Centrum in the U.S.

Adjusted Expenses⁽²⁾, Adjusted Income⁽²⁾ and Adjusted Diluted EPS⁽²⁾ Highlights

	Fourth-Quarter Selected Costs and Expenses
($ in millions) (Favorable)/Unfavorable	2012			2011			Change		Foreign Exchange		Operational
Adjusted Cost of Sales^(2)	$	3,106		$	3,083		1	%	8	%	(7	%)
As a Percent of Revenues		20.6	%		19.1	%	N/A		N/A		N/A
Adjusted SI&A Expenses^(2)		4,658			5,173		(10	%)	(1	%)	(9	%)
Adjusted R&D Expenses^(2)		2,000			2,318		(14	%)	(1	%)	(13	%)
Total	$	9,764		$	10,574		(8	%)	1	%	(9	%)

See end of text prior to tables for notes.

Adjusted cost of sales⁽²⁾, adjusted SI&A expenses⁽²⁾ and adjusted R&D expenses⁽²⁾ in the aggregate were $9.8 billion in fourth-quarter 2012, a decrease of 8% compared with $10.6 billion in fourth-quarter 2011. Excluding the unfavorable impact of foreign exchange of $161 million, or 1%, these costs decreased 9%, primarily reflecting the benefits of cost-reduction and productivity initiatives.

Savings in adjusted R&D expenses⁽²⁾ were generated in fourth-quarter 2012 primarily by the discontinuation of certain therapeutic areas and R&D programs in connection with our previously announced initiatives. Lower adjusted SI&A expenses⁽²⁾ compared with the year-ago period primarily reflect a reduction in the field force and a decrease in promotional spending, both partially in response to product losses of exclusivity, and more streamlined corporate support functions. Adjusted cost of sales⁽²⁾ and adjusted cost of sales⁽²⁾ as a percent of revenues were favorably impacted by the benefits generated from the ongoing cost-reduction and productivity initiatives to streamline the manufacturing network, while unfavorably impacted by the decline in revenues contributing to a shift in geographic, business and product mix as well as by foreign exchange. Additionally, adjusted cost of sales⁽²⁾ compared with the same period last year reflects reduced manufacturing volumes given the aforementioned products that lost exclusivity in various markets.

In full-year 2012, adjusted cost of sales⁽²⁾, adjusted SI&A expenses⁽²⁾ and adjusted R&D expenses⁽²⁾ in the aggregate were $34.6 billion, a decrease of 12% compared with $39.2 billion in full-year 2011. Excluding the favorable impact of foreign exchange of $840 million, or 2%, these costs decreased 10%, primarily reflecting the aforementioned items.

The fourth-quarter 2012 effective tax rate on adjusted income⁽²⁾ was 31.0%, compared with 29.8% in fourth-quarter 2011. The 2012 full-year effective tax rate on adjusted income⁽²⁾ was 29.3%, compared with 29.6% for the full-year 2011. The rates for 2012 compared with the prior-year rates reflect the impact of the change in the jurisdictional mix of earnings and the expiration of the U.S. research and development tax credit. The full-year 2012 effective tax rate compared to the prior-year rate also reflects the favorable impact of the resolution of foreign audits pertaining to multiple tax years, recorded in third-quarter 2012.

The diluted weighted-average shares outstanding for fourth-quarter and full-year 2012 were 7.4 billion and 7.5 billion shares, respectively, a reduction of approximately 292 million and 362 million shares, respectively, compared with the same periods in 2011. These declines were primarily due to the Company’s ongoing share-repurchase program.

As a result of the aforementioned factors, fourth-quarter 2012 adjusted income⁽²⁾ was $3.5 billion, a decrease of 7% compared with $3.8 billion in the year-ago quarter, and adjusted diluted EPS⁽²⁾ was $0.47, a decrease of 4% compared with $0.49 in fourth-quarter 2011. Full-year 2012 adjusted income⁽²⁾ was $16.5 billion, a decrease of 8% compared with $17.8 billion in full-year 2011, and adjusted diluted EPS⁽²⁾ was $2.19, a decrease of 4% compared with $2.27 in full-year 2011.

Reported Net Income⁽³⁾ and Reported Diluted EPS⁽³⁾ Highlights

In addition to the aforementioned factors, fourth-quarter and full-year 2012 reported earnings in comparison with the same periods in 2011 were favorably impacted by the gain on the sale of the Nutrition⁽¹⁾ business, lower purchase accounting adjustments, lower acquisition-related costs and lower costs related to cost-reduction and productivity initiatives, while unfavorably impacted by higher costs associated with the potential separation of Zoetis⁽⁴⁾. Full-year 2012 reported earnings in comparison with full-year 2011 were also unfavorably impacted by certain legal charges, primarily associated with hormone-replacement therapy, Rapamune, Celebrex and Chantix, and the non-recurrence of the gain on the sale of Capsugel⁽⁵⁾ recorded in third-quarter 2011.

The fourth-quarter 2012 effective tax rate on reported results was 31.3%, compared with 34.4% in fourth-quarter 2011. The full-year 2012 effective tax rate on reported results was 21.2%, compared with 31.8% for full-year 2011. The lower rates for 2012 compared with the prior-year rates reflect the impact of the change in the jurisdictional mix of earnings and the expiration of the U.S. research and development tax credit. The full-year 2012 effective tax rate was also favorably impacted by a settlement with the U.S. Internal Revenue Service related to audits for multiple tax years and the aforementioned resolution of foreign audits, partially offset by the unfavorable impact of the non-deductibility of the aforementioned legal charge related to Rapamune, all recorded in third-quarter 2012.

As a result of all these factors, fourth-quarter 2012 reported net income⁽³⁾ was $6.3 billion, compared with $1.4 billion in the prior-year quarter, and reported diluted EPS⁽³⁾ was $0.85, compared with $0.19 in fourth-quarter 2011. Full-year 2012 reported net income⁽³⁾ was $14.6 billion, an increase of 46% compared with $10.0 billion in full-year 2011, and reported diluted EPS⁽³⁾ was $1.94, an increase of 53% compared with $1.27 in full-year 2011.

Executive Commentary

Ian Read, Chairman and Chief Executive Officer, stated, “In 2012, we generated attractive returns for our shareholders and made meaningful progress in positioning Pfizer for anticipated sustained value creation. Notable achievements during 2012 included approvals of five important new products in key markets, realizing significant value through the sale of our Nutrition⁽¹⁾ business, preparation for our potential initial public offering of up to a 19.8% stake in Zoetis⁽⁴⁾ in order to further unlock value, as well as returning almost $15 billion to our shareholders through dividends and share repurchases. In addition, many of our key innovative products reported solid operational growth, and our Emerging Markets business generated strong growth. We continued to make important advances in our mid-to-late stage pipeline, notably in the oncology and vaccines areas, effectively managed our cost structure and progressed key initiatives that I believe will drive future growth. These achievements reflect the continued hard work and commitment of our colleagues in support of Pfizer’s ability to realize long-term success.”

“During 2013, we will continue to foster our two distinct operating models in order to best support our innovative and value-driven businesses and position them to generate peak performance. We also look forward to successful launches for Xeljanz for the treatment of moderate-to-severe rheumatoid arthritis and, together with our partner Bristol-Myers Squibb, Eliquis for the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. These opportunities represent important new therapies in high-need markets. In addition, our mid-to-late stage pipeline continues to strengthen with key potential opportunities, including palbociclib (PD-332991) for advanced breast cancer, RN316 (PCSK9) for lowering LDL cholesterol, dacomitinib for advanced non-small cell lung cancer, inotuzumab for aggressive non-Hodgkin's lymphoma and acute lymphoblastic leukemia, Xeljanz for psoriasis, and the rLP2086 vaccine for meningococcal B in adolescents and young adults. In addition, I expect that ‘bolt-on’ business development will continue to play an important role in supplementing our internal efforts.”

“In summary, we remain intently focused on continued value creation for our shareholders, driving meaningful innovation and pursuing the most attractive opportunities for deployment of our shareholders’ capital,” concluded Mr. Read.

Frank D’Amelio, Chief Financial Officer, stated, “Overall, I am pleased with our 2012 financial performance, our recent product approvals and our expense reductions, as evidenced by the $4.5 billion decline in adjusted cost of sales, SI&A expenses and R&D expenses⁽²⁾ in the aggregate compared with 2011. Additionally, we completed an important strategic initiative through the sale of our Nutrition⁽¹⁾ business to Nestlé, and are ready to execute on another important strategic initiative with the potential initial public offering of up to a 19.8% stake in Zoetis⁽⁴⁾, after having recently completed a related $3.65 billion debt offering. We continue to expect to allocate the proceeds from these transactions to share repurchases while also considering other value-creating opportunities, with the return on share repurchases remaining the case to beat.”

“We are also providing our initial 2013 financial guidance, including a range for revenues of $56.2 to $58.2 billion and for adjusted diluted EPS⁽²⁾ of $2.20 to $2.30. Our guidance reflects the benefit of a full-year contribution from Zoetis⁽⁴⁾, partially offset by an unfavorable $0.02 adjusted⁽²⁾ and reported⁽³⁾ diluted EPS impact for Zoetis⁽⁴⁾-related interest expense associated with the $3.65 billion debt offering and certain duplicative and other costs given the potential separation of Zoetis⁽⁴⁾. Additionally, our revenue guidance reflects the anticipated negative impact of approximately $4 billion due to product losses of exclusivity and the near-term expiration of certain co-promotion agreements. We expect adjusted SI&A expenses⁽²⁾ to be between $15.6 billion and $16.6 billion, with the mid-point below the 2012 level. Notably, we expect SI&A expenses will include substantial expenses associated with the launches of various key medicines, including Eliquis, Xeljanz and Prevnar/Prevenar 13 for adults, but plan to essentially offset those incremental expenses through our cost-reduction initiatives. Lastly, we expect to continue to deploy significant capital to share repurchases during the year,” concluded Mr. D’Amelio.

2013 Financial Guidance

Pfizer’s financial guidance is summarized below.
Reported Revenues	$56.2 to $58.2 billion
Adjusted Cost of Sales^(2) as a Percentage of Revenues	19.0% to 20.0%
Adjusted SI&A Expenses^(2)	$15.6 to $16.6 billion
Adjusted R&D Expenses^(2)	$6.5 to $7.0 billion
Adjusted Other (Income)/Deductions^(2)	Approximately $900 million
Effective Tax Rate on Adjusted Income^(2)	Approximately 28.0%
Reported Diluted EPS^(3)	$1.50 to $1.65
Adjusted Diluted EPS^(2)	$2.20 to $2.30

The exchange rates assumed in connection with the 2013 financial guidance are as of mid-January 2013.

The 2013 financial guidance does not assume the completion of any business development transactions not completed as of December 31, 2012, including any one-time upfront payments associated with such transactions, and excludes the potential effects of the resolution of litigation-related matters not substantially resolved as of December 31, 2012.

The 2013 financial guidance reflects the benefit of a full-year contribution from Zoetis⁽⁴⁾. Adjusted⁽²⁾ and Reported⁽³⁾ Diluted EPS guidance includes a $0.02 unfavorable impact for Zoetis⁽⁴⁾-related interest expense and certain duplicative and other costs given its potential separation. Reported Diluted EPS⁽³⁾ guidance includes an additional $0.02 unfavorable impact for costs related to the establishment of Zoetis’⁽⁴⁾ corporate and manufacturing support functions, and certain other costs related to the potential separation of Zoetis⁽⁴⁾ from Pfizer, including new branding, creation of a standalone infrastructure, site separation and certain legal registration and patent assignment costs.

For additional details, please see the attached financial schedules, product revenue tables, supplemental information and disclosure notice.

(1)	On November 30, 2012, Pfizer completed the sale of the Nutrition business to Nestlé. The operating results of the Nutrition business are reported as Discontinued Operations – net of tax in the consolidated statements of income for all periods presented. The gain on the sale of the Nutrition business is reported as Discontinued Operations – net of tax in the consolidated statements of income for fourth-quarter and full-year 2012.
(2)	"Adjusted Income" and its components and "Adjusted Diluted Earnings Per Share (EPS)" are defined as reported U.S. generally accepted accounting principles (GAAP) net income^(3) and its components and reported diluted EPS^(3) excluding purchase accounting adjustments, acquisition-related costs, discontinued operations and certain significant items. Adjusted Cost of Sales, Adjusted Selling, Informational and Administrative (SI&A) expenses, Adjusted Research and Development (R&D) expenses and Adjusted Other (Income)/Deductions are income statement line items prepared on the same basis, and, therefore, components of the overall adjusted income measure. As described under Adjusted Income in the Management’s Discussion and Analysis of Financial Condition and Results of Operations section of Pfizer's Form 10-Q for the fiscal quarter ended September 30, 2012, management uses adjusted income, among other factors, to set performance goals and to measure the performance of the overall company. We believe that investors' understanding of our performance is enhanced by disclosing this measure. Reconciliations of certain GAAP reported to non-GAAP adjusted information for the fourth-quarter and full-year 2012 and 2011, as well as reconciliations of full-year 2013 guidance for adjusted income and adjusted diluted EPS to full-year 2013 guidance for reported net income^(3) and reported diluted EPS^(3), are provided in the materials accompanying this report. The adjusted income and its components and adjusted diluted EPS measures are not, and should not be viewed as, substitutes for U.S. GAAP net income and its components and diluted EPS.
(3)	“Reported Net Income” is defined as net income attributable to Pfizer Inc. in accordance with U.S. GAAP. “Reported Diluted EPS” is defined as reported diluted EPS attributable to Pfizer Inc. common shareholders in accordance with U.S. GAAP.
(4)	Pfizer previously announced its intention to initiate a potential initial public offering of up to a 19.8% stake in Zoetis Inc. (Zoetis), a subsidiary of Pfizer, and Zoetis has filed a registration statement with the Securities and Exchange Commission. Upon completion of the potential initial public offering, Pfizer will have transferred substantially all of its animal health business assets and liabilities to Zoetis. The financial results of Zoetis differ from the financial results of the Animal Health business unit as the components of this unit differ from Zoetis and, therefore, the financial results of the Animal Health business unit should not be relied upon as indicative of the performance of Zoetis.
(5)	On August 1, 2011, Pfizer completed the sale of Capsugel to an affiliate of Kohlberg Kravis Roberts & Co. L.P. The operating results and the gain on the sale of Capsugel are reported as Discontinued operations – net of tax in the consolidated statements of income for full-year 2011. Additionally, due to the acquisition of King Pharmaceuticals, Inc. (King), legacy King operations are reflected in the results beginning January 31, 2011. Therefore, in accordance with Pfizer’s domestic and international reporting periods, in full-year 2011 the operating results reflect approximately eleven months of King’s U.S. operations and approximately ten months of King’s international operations.
(6)	For a description of each business unit, see Note 13A to Pfizer’s condensed consolidated financial statements included in Pfizer’s Form 10-Q for the fiscal quarter ended September 30, 2012.
(7)	Other includes revenues generated primarily from Pfizer CentreSource, Pfizer’s contract manufacturing and bulk pharmaceutical chemical sales organization.

PFIZER INC. AND SUBSIDIARY COMPANIES CONSOLIDATED STATEMENTS OF INCOME^(a) (UNAUDITED) (millions, except per common share data)
			Fourth-Quarter				% Incr. /	Full-Year				% Incr. /
				2012		2011	(Decr.)		2012		2011	(Decr.)
	Revenues		$	15,068	$	16,141	(7)	$	58,986	$	65,259	(10)
	Costs and expenses:
		Cost of sales^(b)		3,172		3,627	(13)		11,334		14,076	(19)
		Selling, informational and administrative expenses^(b)		4,815		5,197	(7)		16,616		18,832	(12)
		Research and development expenses^(b)		2,136		2,587	(17)		7,870		9,074	(13)
		Amortization of intangible assets^(c)		1,236		1,406	(12)		5,175		5,544	(7)
		Restructuring charges and certain acquisition-related costs		791		472	68		1,880		2,930	(36)
		Other deductions--net		748		697	7		4,031		2,499	61
	Income from continuing operations before provision
		for taxes on income		2,170		2,155	1		12,080		12,304	(2)
	Provision for taxes on income			680		742	(8)		2,562		3,909	(34)
	Income from continuing operations			1,490		1,413	5		9,518		8,395	13
	Discontinued operations--net of tax			4,831		35	*		5,080		1,654	207
	Net income before allocation to noncontrolling interests			6,321		1,448	*		14,598		10,049	45
	Less: Net income attributable to noncontrolling interests			6		9	(33)		28		40	(30)
	Net income attributable to Pfizer Inc.		$	6,315	$	1,439	*	$	14,570	$	10,009	46
	Earnings per common share--basic:^(d)
		Income from continuing operations attributable to
		Pfizer Inc. common shareholders	$	0.20	$	0.18	11	$	1.27	$	1.07	19
		Discontinued operations--net of tax		0.66		-	*		0.68		0.21	224
		Net income attributable to Pfizer Inc. common shareholders	$	0.86	$	0.19	*	$	1.96	$	1.28	53
	Earnings per common share--diluted:^(d)
		Income from continuing operations attributable to
		Pfizer Inc. common shareholders	$	0.20	$	0.18	11	$	1.26	$	1.06	19
		Discontinued operations--net of tax		0.65		-	*		0.68		0.21	224
		Net income attributable to Pfizer Inc. common shareholders	$	0.85	$	0.19	*	$	1.94	$	1.27	53
	Weighted-average shares used to calculate earnings per common share:
		Basic		7,319		7,635			7,442		7,817
		Diluted		7,395		7,687			7,508		7,870

(a)	The above financial statements present the three and twelve months ended December 31, 2012 and 2011. Subsidiaries operating outside the United States are included for the three and twelve months ended November 30, 2012 and 2011.
	On November 30, 2012, we completed the sale of our Nutrition business and recognized a gain of approximately $4.8 billion related to the sale of this business in Discontinued operations--net of tax for the three and twelve months ended December 31, 2012. The operating results of this business are reported as Discontinued operations--net of tax for all periods presented.
	On August 1, 2011, we completed the sale of our Capsugel business and recognized a gain of approximately $1.3 billion related to the sale of this business. The gain and the operating results of this business are reported as Discontinued operations--net of tax for the twelve months ended December 31, 2011.
	On January 31, 2011, we completed a tender offer for the outstanding shares of common stock of King Pharmaceuticals, Inc. (King) and, commencing from that date, our financial statements include the assets, liabilities, operating results and cash flows of King. As a result, and in accordance with our domestic and international reporting periods, our operating results for the twelve months ended December 31, 2011 reflect approximately eleven months of King’s U.S. operations and approximately ten months of King’s international operations.
	* Calculation not meaningful.
	Certain amounts and percentages may reflect rounding adjustments.
	See Supplemental Information that accompanies these materials for additional details.
(b)	Exclusive of amortization of intangible assets, except as discussed in footnote (c) below.
(c)	Amortization expense related to acquired intangible assets that contribute to our ability to sell, manufacture, research, market and distribute products, compounds and intellectual property is included in Amortization of intangible assets as these intangible assets benefit multiple business functions. Amortization expense related to acquired intangible assets that are associated with a single function is included in Cost of sales, Selling, informational and administrative expenses or Research and development expenses, as appropriate.
(d)	EPS amounts may not add due to rounding.

PFIZER INC. AND SUBSIDIARY COMPANIES RECONCILIATION OF GAAP REPORTED TO NON-GAAP ADJUSTED INFORMATION CERTAIN LINE ITEMS (UNAUDITED) (millions of dollars, except per common share data)
			Quarter Ended December 31, 2012
			GAAP Reported^(1)		Purchase Accounting Adjustments		Acquisition- Related Costs^(2)		Discontinued Operations		Certain Significant Items^(3)		Non-GAAP Adjusted^(a)
	Revenues	$	15,068	$	-	$	-	$	-	$	-	$	15,068
	Cost of sales^(b)		3,172		4		(53)		-		(17)		3,106
	Selling, informational and administrative expenses^(b)		4,815		9		(1)		-		(165)		4,658
	Research and development expenses^(b)		2,136		-		(1)		-		(135)		2,000
	Amortization of intangible assets^(c)		1,236		(1,210)		-		-		-		26
	Restructuring charges and certain acquisition-related costs		791		-		(262)		-		(529)		-
	Other deductions--net		748		(10)		-		-		(557)		181
	Income from continuing operations before provision for taxes on income		2,170		1,207		317		-		1,403		5,097
	Provision for taxes on income		680		334		50		-		515		1,579
	Income from continuing operations		1,490		873		267		-		888		3,518
	Discontinued operations--net of tax		4,831		-		-		(4,831)		-		-
	Net income attributable to noncontrolling interests		6		-		-		-		-		6
	Net income attributable to Pfizer Inc.		6,315		873		267		(4,831)		888		3,512
	Earnings per common share attributable to Pfizer Inc.--diluted^(d)		0.85		0.12		0.04		(0.65)		0.12		0.47
			Twelve Months Ended December 31, 2012
			GAAP Reported^(1)		Purchase Accounting Adjustments		Acquisition- Related Costs^(2)		Discontinued Operations		Certain Significant Items^(3)		Non-GAAP Adjusted^(a)
	Revenues	$	58,986	$	-	$	-	$	-	$	-	$	58,986
	Cost of sales^(b)		11,334		(5)		(267)		-		(68)		10,994
	Selling, informational and administrative expenses^(b)		16,616		13		(9)		-		(339)		16,281
	Research and development expenses^(b)		7,870		3		(6)		-		(521)		7,346
	Amortization of intangible assets^(c)		5,175		(4,973)		-		-		-		202
	Restructuring charges and certain acquisition-related costs		1,880		-		(685)		-		(1,195)		-
	Other deductions--net		4,031		5		-		-		(3,201)		835
	Income from continuing operations before provision for taxes on income		12,080		4,957		967		-		5,324		23,328
	Provision for taxes on income		2,562		1,359		211		-		2,692		6,824
	Income from continuing operations		9,518		3,598		756		-		2,632		16,504
	Discontinued operations--net of tax		5,080		-		-		(5,080)		-		-
	Net income attributable to noncontrolling interests		28		-		-		-		-		28
	Net income attributable to Pfizer Inc.		14,570		3,598		756		(5,080)		2,632		16,476
	Earnings per common share attributable to Pfizer Inc.--diluted^(d)		1.94		0.48		0.10		(0.68)		0.35		2.19

(a)	Non-GAAP Adjusted income and its components and Non-GAAP Adjusted diluted EPS are not, and should not be viewed as, substitutes for U.S. GAAP net income and its components and diluted EPS. Despite the importance of these measures to management in goal setting and performance measurement, Non-GAAP Adjusted income and its components and Non-GAAP Adjusted diluted EPS are Non-GAAP financial measures that have no standardized meaning prescribed by U.S. GAAP and, therefore, have limits in their usefulness to investors. Because of the non-standardized definitions, Non-GAAP Adjusted income and its components and Non-GAAP Adjusted diluted EPS (unlike U.S. GAAP net income and its components and diluted EPS) may not be comparable to the calculation of similar measures of other companies. Non-GAAP Adjusted income and its components and Non-GAAP Adjusted diluted EPS are presented solely to permit investors to more fully understand how management assesses performance.
(b)	Exclusive of amortization of intangible assets, except as discussed in footnote (c) below.
(c)	Amortization expense related to acquired intangible assets that contribute to our ability to sell, manufacture, research, market and distribute products, compounds and intellectual property is included in Amortization of intangible assets as these intangible assets benefit multiple business functions. Amortization expense related to acquired intangible assets that are associated with a single function is included in Cost of sales, Selling, informational and administrative expensesor Research and development expenses, as appropriate.
(d)	EPS amounts may not add due to rounding.
See end of tables for notes (1), (2) and (3).
Certain amounts may reflect rounding adjustments.

PFIZER INC. AND SUBSIDIARY COMPANIES RECONCILIATION OF GAAP REPORTED TO NON-GAAP ADJUSTED INFORMATION CERTAIN LINE ITEMS (UNAUDITED) (millions of dollars, except per common share data)
		Quarter Ended December 31, 2011
			GAAP Reported^(1)		Purchase Accounting Adjustments		Acquisition- Related Costs^(2)		Discontinued Operations		Certain Significant Items^(3)		Non-GAAP Adjusted^(a)
	Revenues	$	16,141	$	-	$	-	$	-	$	-	$	16,141
	Cost of sales^(b)		3,627		(149)		(145)		-		(250)		3,083
	Selling, informational and administrative expenses^(b)		5,197		(5)		(4)		-		(15)		5,173
	Research and development expenses^(b)		2,587		2		(14)		-		(257)		2,318
	Amortization of intangible assets^(c)		1,406		(1,353)		-		-		-		53
	Restructuring charges and certain acquisition-related costs		472		-		(360)		-		(112)		-
	Other deductions--net		697		(51)		-		-		(538)		108
	Income from continuing operations before provision for taxes on income		2,155		1,556		523		-		1,172		5,406
	Provision for taxes on income		742		408		202		-		261		1,613
	Income from continuing operations		1,413		1,148		321		-		911		3,793
	Discontinued operations--net of tax		35		-		-		(35)		-		-
	Net income attributable to noncontrolling interests		9		-		-		-		-		9
	Net income attributable to Pfizer Inc.		1,439		1,148		321		(35)		911		3,784
	Earnings per common share attributable to Pfizer Inc.--diluted^(d)		0.19		0.15		0.04		-		0.12		0.49
			Twelve Months Ended December 31, 2011
			GAAP Reported^(1)		Purchase Accounting Adjustments		Acquisition- Related Costs^(2)		Discontinued Operations		Certain Significant Items^(3)		Non-GAAP Adjusted^(a)
	Revenues	$	65,259	$	-	$	-	$	-	$	-	$	65,259
	Cost of sales^(b)		14,076		(1,230)		(555)		-		(257)		12,034
	Selling, informational and administrative expenses^(b)		18,832		(11)		(45)		-		(54)		18,722
	Research and development expenses^(b)		9,074		2		(23)		-		(655)		8,398
	Amortization of intangible assets^(c)		5,544		(5,392)		-		-		-		152
	Restructuring charges and certain acquisition-related costs		2,930		-		(1,356)		-		(1,574)		-
	Other deductions--net		2,499		(122)		-		-		(1,807)		570
	Income from continuing operations before provision for taxes on income		12,304		6,753		1,979		-		4,347		25,383
	Provision for taxes on income		3,909		1,753		522		-		1,320		7,504
	Income from continuing operations		8,395		5,000		1,457		-		3,027		17,879
	Discontinued operations--net of tax		1,654		-		-		(1,654)		-		-
	Net income attributable to noncontrolling interests		40		-		-		-		-		40
	Net income attributable to Pfizer Inc.		10,009		5,000		1,457		(1,654)		3,027		17,839
	Earnings per common share attributable to Pfizer Inc.--diluted^(d)		1.27		0.64		0.19		(0.21)		0.38		2.27

(a)	Non-GAAP Adjusted income and its components and Non-GAAP Adjusted diluted EPS are not, and should not be viewed as, substitutes for U.S. GAAP net income and its components and diluted EPS. Despite the importance of these measures to management in goal setting and performance measurement, Non-GAAP Adjusted income and its components and Non-GAAP Adjusted diluted EPS are Non-GAAP financial measures that have no standardized meaning prescribed by U.S. GAAP and, therefore, have limits in their usefulness to investors. Because of the non-standardized definitions, Non-GAAP Adjusted income and its components and Non-GAAP Adjusted diluted EPS (unlike U.S. GAAP net income and its components and diluted EPS) may not be comparable to the calculation of similar measures of other companies. Non-GAAP Adjusted income and its components and Non-GAAP Adjusted diluted EPS are presented solely to permit investors to more fully understand how management assesses performance.
(b)	Exclusive of amortization of intangible assets, except as discussed in footnote (c) below.
(c)	Amortization expense related to acquired intangible assets that contribute to our ability to sell, manufacture, research, market and distribute products, compounds and intellectual property is included in Amortization of intangible assets as these intangible assets benefit multiple business functions. Amortization expense related to acquired intangible assets that are associated with a single function is included in Cost of sales, Selling, informational and administrative expenses or Research and development expenses, as appropriate.
(d)	EPS amounts may not add due to rounding.
See end of tables for notes (1), (2) and (3).
Certain amounts may reflect rounding adjustments.

PFIZER INC. AND SUBSIDIARY COMPANIES NOTES TO RECONCILIATION OF GAAP REPORTED TO NON-GAAP ADJUSTED INFORMATION CERTAIN LINE ITEMS* (UNAUDITED)
(1)	The financial statements present the three and twelve months ended December 31, 2012 and 2011. Subsidiaries operating outside the United States are included for the three and twelve months ended November 30, 2012 and 2011.
	On November 30, 2012, we completed the sale of our Nutrition business and recognized a gain of approximately $4.8 billion related to the sale of this business in Discontinued operations--net of tax for the three and twelve months ended December 31, 2012. The operating results of this business are reported as Discontinued operations--net of tax for all periods presented.
	On August 1, 2011, we completed the sale of our Capsugel business and recognized a gain of approximately $1.3 billion related to the sale of this business. The gain and the operating results of this business are reported as Discontinued operations--net of tax for the twelve months ended December 31, 2011.
	On January 31, 2011, we completed a tender offer for the outstanding shares of common stock of King Pharmaceuticals, Inc. (King) and, commencing from that date, our financial statements include the assets, liabilities, operating results and cash flows of King. As a result, and in accordance with our domestic and international reporting periods, our operating results for the twelve months ended December 31, 2011 reflect approximately eleven months of King’s U.S. operations and approximately ten months of King’s international operations.
(2)	Acquisition-related costs include the following:

	Fourth-Quarter						Full-Year
(millions of dollars)		2012			2011			2012			2011
Transaction costs^(a)	$	-		$	2		$	1		$	30
Integration costs^(a)		110			163			405			725
Restructuring charges^(a)		152			195			279			601
Additional depreciation -- asset restructuring^(b)		55			163			282			623
Total acquisition-related costs -- pre-tax		317			523			967			1,979
Income taxes^(c)		(50	)		(202	)		(211	)		(522	)
Total acquisition-related costs -- net of tax	$	267		$	321		$	756		$	1,457

	(a)	Transaction costs represent external costs directly related to acquired businesses and primarily include expenditures for banking, legal, accounting and other similar services. Integration costs represent external, incremental costs directly related to integrating acquired businesses, and primarily include expenditures for consulting and the integration of systems and processes. Restructuring charges include employee termination costs, asset impairments and other exit costs associated with business combinations. All of these costs and charges are included in Restructuring charges and certain acquisition-related costs.
	(b)	Represents the impact of changes in the estimated useful lives of assets involved in restructuring actions related to acquisitions. Included in Cost of sales ($53 million), Selling, informational and administrative expenses ($1 million), and Research and development expenses ($1 million) for the three months ended December 31, 2012. Included in Cost of sales ($267 million), Selling, informational and administrative expenses ($9 million) and Research and development expenses ($6 million) for the twelve months ended December 31, 2012. Included in Cost of sales ($145 million), Selling, informational and administrative expenses ($4 million) and Research and development expenses ($14 million) for the three months ended December 31, 2011. Included in Cost of sales ($555 million), Selling, informational and administrative expenses ($45 million) and Research and development expenses ($23 million) for the twelve months ended December 31, 2011.
	(c)	Included in Provision for taxes on income.
(3)	Certain significant items include the following:

	Fourth-Quarter						Full-Year
(millions of dollars)		2012			2011			2012			2011
Restructuring charges^(a)	$	529		$	112		$	1,195		$	1,574
Implementation costs and additional depreciation -- asset restructuring^(b)		207			522			693			959
Certain legal matters^(c)		208			165			2,191			822
Certain asset impairment charges^(d)		369			261			912			856
Costs associated with the potential separation of Zoetis^(e)		134			27			325			35
Other		(44	)		85			8			101
Total certain significant items -- pre-tax		1,403			1,172			5,324			4,347
Income taxes^(f)		(515	)		(261	)		(2,692	)		(1,320	)
Total certain significant items -- net of tax	$	888		$	911		$	2,632		$	3,027

	(a)	Primarily related to our cost-reduction and productivity initiatives, included in Restructuring charges and certain acquisition-related costs.
	(b)	Primarily related to our cost-reduction and productivity initiatives. Included in Cost of sales ($8 million), Selling, informational and administrative expenses ($64 million) and Research and development expenses ($135 million) for the three months ended December 31, 2012. Included in Cost of sales ($31 million), Selling, informational and administrative expenses ($141 million) and Research and development expenses ($521 million) for the twelve months ended December 31, 2012. Included in Cost of sales ($250 million), Selling, informational and administrative expenses ($15 million) and Research and development expenses ($257 million) for the three months ended December 31, 2011. Included in Cost of sales ($250 million), Selling, informational and administrative expenses ($54 million) and Research and development expenses ($655 million) for the twelve months ended December 31, 2011.
	(c)	Included in Other deductions--net. In fourth-quarter 2012, primarily includes charges related to Chantix litigation. In full-year 2012, primarily includes a $491 million charge resulting from an agreement-in-principle with the U.S. Department of Justice to resolve an investigation into Wyeth’s historical promotional practices in connection with Rapamune, a $450 million settlement of a lawsuit by Brigham Young University related to Celebrex, and charges related to hormone-replacement therapy litigation and Chantix litigation. In 2011, primarily includes charges for hormone-replacement therapy litigation.
	(d)	Primarily included in Other deductions--net. In fourth-quarter and full-year 2012, primarily relates to certain intangible assets acquired in connection with our acquisitions of Wyeth and King, including in-process research and development (IPR&D) intangible assets. In fourth-quarter 2011, primarily relates to our indefinite-lived brand asset, Xanax, as a result of an increased competitive environment. In full-year 2011, substantially all relates to certain intangible assets acquired in connection with our acquisition of Wyeth, including IPR&D intangible assets, and our indefinite-lived brand asset, Xanax, as mentioned in the previous sentence.
	(e)	Costs incurred in connection with the potential initial public offering of up to a 19.8% ownership stake in Zoetis. Includes expenditures for banking, legal, accounting and similar services related to the potential transaction, as well as costs incurred associated with the potential separation of Zoetis employees, net assets and operations from Pfizer, such as consulting and systems costs. Included in Cost of sales ($6 million), Selling, informational and administrative expenses ($96 million) and Other deductions--net ($32 million) for the three months ended December 31, 2012. Included in Cost of sales ($6 million), Selling, informational and administrative expenses ($194 million) and Other deductions--net ($125 million) for the twelve months ended December 31, 2012. For the three and twelve months ended December 31, 2011, substantially all included in Other deductions--net.
	(f)	Included in Provision for taxes on income. Includes a settlement with the U.S. IRS related to audits for multiple tax years of $1.1 billion, representing tax and interest, for the twelve months ended December 31, 2012.
*	Non-GAAP Adjusted income and its components and Non-GAAP Adjusted diluted EPS are not, and should not be viewed as, substitutes for U.S. GAAP net income and its components and diluted EPS. Despite the importance of these measures to management in goal setting and performance measurement, Non-GAAP Adjusted income and its components and Non-GAAP Adjusted diluted EPS are Non-GAAP financial measures that have no standardized meaning prescribed by U.S. GAAP and, therefore, have limits in their usefulness to investors. Because of the non-standardized definitions, Non-GAAP Adjusted income and its components and Non-GAAP Adjusted diluted EPS (unlike U.S. GAAP net income and its components and diluted EPS) may not be comparable to the calculation of similar measures of other companies. Non-GAAP Adjusted income and its components and Non-GAAP Adjusted diluted EPS are presented solely to permit investors to more fully understand how management assesses performance.

PFIZER INC. BUSINESS REVENUES^(1) TWELVE MONTHS 2012 AND 2011 (UNAUDITED) (millions of dollars)
		2012		2011	Change		Foreign Exchange		Operational
Primary Care	$	15,558	$	22,670	(31	%)	(1	%)	(30	%)
Specialty Care		14,151		15,245	(7	%)	(2	%)	(5	%)
Established Products		10,235		9,214	11	%	(2	%)	13	%
Emerging Markets		9,960		9,295	7	%	(5	%)	12	%
Oncology		1,310		1,323	(1	%)	(3	%)	2	%
Biopharmaceutical		51,214		57,747	(11	%)	(2	%)	(9	%)
Animal Health		4,299		4,184	3	%	(3	%)	6	%
Consumer Healthcare		3,212		3,028	6	%	(2	%)	8	%
Other		261		300	(13	%)	(1	%)	(12	%)
Total	$	58,986	$	65,259	(10	%)	(2	%)	(8	%)
(1) For a description of each business unit, see Note 13A to Pfizer's condensed consolidated financial statements included in Pfizer's Form 10-Q for the fiscal quarter ended September 30, 2012.

PFIZER INC. ADJUSTED SELECTED COSTS AND EXPENSES TWELVE MONTHS 2012 AND 2011 (UNAUDITED)
($ in millions)									Foreign
(Favorable)/Unfavorable	2012			2011			Change		Exchange		Operational
Adjusted Cost of Sales^(1)	$	10,994		$	12,034		(9	%)	(4	%)	(5	%)
As a Percent of Revenues		18.6	%		18.4	%	N/A		N/A		N/A
Adjusted SI&A Expenses^(1)		16,281			18,722		(13	%)	(2	%)	(11	%)
Adjusted R&D Expenses^(1)		7,346			8,398		(13	%)	(1	%)	(12	%)
Total	$	34,621		$	39,154		(12	%)	(2	%)	(10	%)
(1) Adjusted cost of sales, Adjusted selling, informational and administrative (SI&A) expenses and Adjusted research and development (R&D) expenses are defined as the corresponding reported U.S. generally accepted accounting principles (GAAP) income statement line items excluding purchase accounting adjustments, acquisition-related costs, discontinued operations and certain significant items. Reconciliations of certain GAAP reported to non-GAAP adjusted information for the three and twelve months ended December 31, 2012 and 2011 are provided in the materials accompanying this report. These adjusted income statement line item measures are not, and should not be viewed as, substitutes for the corresponding U.S. GAAP line items.

PFIZER INC. REVENUES FOURTH-QUARTER 2012 and 2011 (UNAUDITED) (millions of dollars)
	WORLDWIDE								UNITED STATES						TOTAL INTERNATIONAL^(a)
					% Change								% Change						% Change
	2012		2011		Total		Oper.		2012		2011		Total		2012		2011		Total		Oper.
TOTAL REVENUES	$	15,068	$	16,141	(7	%)	(5	%)	$	5,783	$	6,328	(9	%)	$	9,285	$	9,813	(5	%)	(3	%)
REVENUES FROM BIOPHARMACEUTICAL PRODUCTS:	$	12,893	$	14,136	(9	%)	(7	%)	$	4,809	$	5,459	(12	%)	$	8,084	$	8,677	(7	%)	(4	%)
Lyrica		1,132		998	13	%	16	%		443		398	11	%		689		600	15	%	18	%
Lipitor^(b)		584		1,999	(71	%)	(70	%)		61		816	(93	%)		523		1,183	(56	%)	(55	%)
Enbrel (Outside the U.S. and Canada)		957		925	3	%	8	%		-		-	-			957		925	3	%	8	%
Prevnar 13/Prevenar 13		993		834	19	%	22	%		464		395	17	%		529		439	21	%	25	%
Celebrex		750		667	12	%	13	%		479		418	15	%		271		249	9	%	11	%
Viagra		553		523	6	%	6	%		313		271	15	%		240		252	(5	%)	(3	%)
Norvasc		348		364	(4	%)	(3	%)		10		-	100	%		338		364	(7	%)	(7	%)
Zyvox		349		318	10	%	12	%		175		154	14	%		174		164	6	%	11	%
Sutent		323		317	2	%	5	%		82		89	(8	%)		241		228	6	%	10	%
Premarin family		276		256	8	%	8	%		253		232	9	%		23		24	(4	%)	1	%
Genotropin		213		235	(9	%)	(7	%)		54		61	(11	%)		159		174	(9	%)	(5	%)
Xalatan/Xalacom		189		290	(35	%)	(33	%)		8		17	(53	%)		181		273	(34	%)	(31	%)
BeneFIX		198		175	13	%	15	%		86		78	10	%		112		97	15	%	19	%
Detrol/Detrol LA		185		215	(14	%)	(13	%)		124		135	(8	%)		61		80	(24	%)	(22	%)
Vfend		211		189	12	%	16	%		25		22	14	%		186		167	11	%	18	%
Chantix/Champix		174		175	(1	%)	-			79		78	1	%		95		97	(2	%)	(2	%)
Pristiq		169		155	9	%	9	%		128		126	2	%		41		29	41	%	37	%
Refacto AF/Xyntha		164		126	30	%	33	%		27		22	23	%		137		104	32	%	34	%
Zoloft		143		153	(7	%)	(4	%)		19		17	12	%		124		136	(9	%)	(6	%)
Revatio		120		142	(15	%)	(14	%)		62		83	(25	%)		58		59	(2	%)	1	%
Medrol		135		127	6	%	8	%		35		36	(3	%)		100		91	10	%	13	%
Zosyn/Tazocin		106		146	(27	%)	(26	%)		42		77	(45	%)		64		69	(7	%)	(4	%)
Zithromax/Zmax		117		118	(1	%)	1	%		3		3	-			114		115	(1	%)	1	%
Effexor		83		141	(41	%)	(40	%)		7		35	(80	%)		76		106	(28	%)	(27	%)
Prevnar/Prevenar (7-valent)		96		82	17	%	13	%		-		-	-			96		82	17	%	13	%
Fragmin		98		99	(1	%)	-			6		11	(45	%)		92		88	5	%	6	%
Relpax		102		91	12	%	14	%		59		51	16	%		43		40	8	%	9	%
Rapamune		87		87	-		3	%		45		49	(8	%)		42		38	11	%	16	%
Cardura		84		91	(8	%)	(6	%)		1		1	-			83		90	(8	%)	(7	%)
Tygacil		86		74	16	%	17	%		37		36	3	%		49		38	29	%	33	%
Aricept^(c)		77		115	(33	%)	(33	%)		-		-	-			77		115	(33	%)	(33	%)
Xanax XR		71		74	(4	%)	-			12		11	9	%		59		63	(6	%)	(2	%)
BMP2		71		63	13	%	12	%		71		63	13	%		-		-	-		-
Sulperazon		71		63	13	%	11	%		-		-	-			71		63	13	%	11	%
Diflucan		74		64	16	%	17	%		-		2	(100	%)		74		62	19	%	19	%
Caduet		67		103	(35	%)	(35	%)		7		37	(81	%)		60		66	(9	%)	(9	%)
Neurontin		63		67	(6	%)	(5	%)		11		12	(8	%)		52		55	(5	%)	(6	%)
Dalacin/Cleocin		56		53	6	%	8	%		18		14	29	%		38		39	(3	%)	4	%
Unasyn		63		59	7	%	8	%		-		2	(100	%)		63		57	11	%	11	%
Metaxalone/Skelaxin		74		58	28	%	29	%		74		58	28	%		-		-	-		-
Inspra		58		53	9	%	12	%		1		1	-			57		52	10	%	12	%
Toviaz		57		50	14	%	16	%		31		27	15	%		26		23	13	%	17	%
Somavert		55		50	10	%	14	%		13		12	8	%		42		38	11	%	15	%
Alliance revenues^(d)		915		952	(4	%)	(3	%)		712		599	19	%		203		353	(42	%)	(42	%)
All other biopharmaceutical products^(e)		2,096		2,200	(5	%)	(2	%)		732		910	(20	%)		1,364		1,290	6	%	11	%
All other established products^(e)		1,565		1,464	7	%	9	%		532		496	7	%		1,033		968	7	%	11	%
REVENUES FROM OTHER PRODUCTS:
ANIMAL HEALTH	$	1,171	$	1,106	6	%	8	%	$	482	$	443	9	%	$	689	$	663	4	%	8	%
CONSUMER HEALTHCARE	$	936	$	810	16	%	17	%	$	472	$	403	17	%	$	464	$	407	14	%	16	%
OTHER^(f)	$	68	$	89	(24	%)	(23	%)	$	20	$	23	(13	%)	$	48	$	66	(27	%)	(28	%)

(a)	Total International represents Developed Europe region + Developed Rest of World region + Emerging Markets region. Details for these regions are located on the following page.
(b)	Lipitor lost exclusivity in the U.S. in November 2011 and various other major markets in 2011 and 2012. This loss of exclusivity reduced branded worldwide revenues by $1.4 billion in the fourth quarter of 2012, in comparison with the fourth quarter of 2011.
(c)	Represents direct sales under license agreement with Eisai Co., Ltd.
(d)	Includes Enbrel (in the U.S. and Canada), Aricept, Exforge, Rebif and Spiriva.
(e)	Includes sales of generic atorvastatin. All other established products is a subset of All other biopharmaceutical products.
(f)	Includes revenues generated primarily from Pfizer CentreSource, our contract manufacturing and bulk pharmaceutical chemical sales organization.
Certain amounts and percentages may reflect rounding adjustments.

PFIZER INC. REVENUES DETAIL OF INTERNATIONAL REVENUES BY GEOGRAPHIC REGION FOURTH-QUARTER 2012 and 2011 (UNAUDITED) (millions of dollars)
	DEVELOPED EUROPE^(a)								DEVELOPED REST OF WORLD^(b)								EMERGING MARKETS^(c)
					% Change								% Change								% Change
	2012		2011		Total		Oper.		2012		2011		Total		Oper.		2012		2011		Total		Oper.
TOTAL INTERNATIONAL REVENUES	$	3,350	$	4,022	(17	%)	(13	%)	$	2,724	$	3,002	(9	%)	(9	%)	$	3,211	$	2,789	15	%	18	%
REVENUES FROM BIOPHARMACEUTICAL PRODUCTS - INTERNATIONAL:	$	2,984	$	3,674	(19	%)	(15	%)	$	2,448	$	2,739	(11	%)	(10	%)	$	2,652	$	2,264	17	%	20	%
Lyrica		364		324	12	%	18	%		217		188	15	%	16	%		108		88	23	%	25	%
Lipitor^(d)		107		596	(82	%)	(81	%)		201		360	(44	%)	(44	%)		215		227	(5	%)	(4	%)
Enbrel (Outside Canada)		627		629	-		4	%		104		133	(22	%)	(21	%)		226		163	39	%	45	%
Prevnar 13/Prevenar 13		208		199	5	%	9	%		65		70	(7	%)	(7	%)		256		170	51	%	58	%
Celebrex		40		48	(17	%)	(10	%)		138		124	11	%	11	%		93		77	21	%	23	%
Viagra		103		104	(1	%)	2	%		49		54	(9	%)	(9	%)		88		94	(6	%)	(5	%)
Norvasc		28		38	(26	%)	(21	%)		171		198	(14	%)	(13	%)		139		128	9	%	8	%
Zyvox		78		77	1	%	6	%		39		41	(5	%)	-			57		46	24	%	28	%
Sutent		114		115	(1	%)	4	%		48		47	2	%	2	%		79		66	20	%	24	%
Premarin family		3		2	50	%	-			9		10	(10	%)	11	%		11		12	(8	%)	-
Genotropin		71		89	(20	%)	(17	%)		58		59	(2	%)	-			30		26	15	%	23	%
Xalatan/Xalacom		55		124	(56	%)	(52	%)		79		99	(20	%)	(19	%)		47		50	(6	%)	(2	%)
BeneFIX		66		62	6	%	10	%		39		31	26	%	33	%		7		4	75	%	50	%
Detrol/Detrol LA		22		38	(42	%)	(39	%)		28		27	4	%	-			11		15	(27	%)	(14	%)
Vfend		78		78	-		5	%		44		45	(2	%)	10	%		64		44	45	%	51	%
Chantix/Champix		35		41	(15	%)	(12	%)		47		46	2	%	-			13		10	30	%	18	%
Pristiq		-		-	-		-			28		19	47	%	30	%		13		10	30	%	40	%
Refacto AF/Xyntha		99		95	4	%	7	%		20		8	150	%	122	%		18		1	*		*
Zoloft		15		20	(25	%)	(20	%)		71		84	(15	%)	(13	%)		38		32	19	%	19	%
Revatio		33		36	(8	%)	(3	%)		16		13	23	%	15	%		9		10	(10	%)	-
Medrol		24		25	(4	%)	4	%		12		13	(8	%)	-			64		53	21	%	23	%
Zosyn/Tazocin		11		14	(21	%)	(14	%)		2		3	(33	%)	-			51		52	(2	%)	-
Zithromax/Zmax		14		19	(26	%)	(22	%)		52		53	(2	%)	(2	%)		48		43	12	%	14	%
Effexor		26		40	(35	%)	(32	%)		22		41	(46	%)	(46	%)		28		25	12	%	16	%
Prevnar/Prevenar (7-valent)		-		1	(100	%)	-			88		81	9	%	12	%		8		-	100	%	60	%
Fragmin		47		46	2	%	7	%		26		20	30	%	10	%		19		22	(14	%)	(5	%)
Relpax		20		20	-		11	%		17		16	6	%	6	%		6		4	50	%	50	%
Rapamune		15		15	-		7	%		5		5	-		-			22		18	22	%	26	%
Cardura		25		25	-		-			32		39	(18	%)	(18	%)		26		26	-		-
Tygacil		17		15	13	%	20	%		2		2	-		-			30		21	43	%	36	%
Aricept^(e)		17		58	(71	%)	(67	%)		51		45	13	%	9	%		9		12	(25	%)	(18	%)
Xanax XR		24		27	(11	%)	(7	%)		11		14	(21	%)	(8	%)		24		22	9	%	9	%
BMP2		-		-	-		-			-		-	-		-			-		-	-		-
Sulperazon		-		-	-		-			9		10	(10	%)	(9	%)		62		53	17	%	15	%
Diflucan		13		21	(38	%)	(33	%)		11		12	(8	%)	(15	%)		50		29	72	%	72	%
Caduet		4		5	(20	%)	(20	%)		41		46	(11	%)	(11	%)		15		15	-		7	%
Neurontin		13		18	(28	%)	(26	%)		14		15	(7	%)	(20	%)		25		22	14	%	14	%
Dalacin/Cleocin		9		9	-		-			5		8	(38	%)	(14	%)		24		22	9	%	9	%
Unasyn		12		8	50	%	63	%		21		20	5	%	-			30		29	3	%	7	%
Metaxalone/Skelaxin		-		-	-		-			-		-	-		-			-		-	-		-
Inspra		35		34	3	%	9	%		17		14	21	%	13	%		5		4	25	%	25	%
Toviaz		22		19	16	%	21	%		1		1	-		-			3		3	-		50	%
Somavert		34		32	6	%	13	%		5		3	67	%	25	%		3		3	-		-
Alliance revenues^(f)		38		103	(63	%)	(60	%)		151		228	(34	%)	(34	%)		14		22	(36	%)	(29	%)
All other biopharmaceutical products^(g)		418		405	3	%	9	%		382		394	(3	%)	2	%		564		491	15	%	19	%
All other established products^(g)		281		290	(3	%)	2	%		265		288	(8	%)	(7	%)		487		390	25	%	30	%
REVENUES FROM OTHER PRODUCTS - INTERNATIONAL:	$	366	$	348	5	%	9	%	$	276	$	263	5	%	3	%	$	559	$	525	6	%	11	%

* Calculation not meaningful.
(a)	Developed Europe region includes the following markets: Western Europe, Finland and the Scandinavian countries.
(b)	Developed Rest of World region includes the following markets: Australia, Canada, Japan, New Zealand and South Korea.
(c)	Emerging Markets region includes, but is not limited to, the following markets: Asia (excluding Japan and South Korea), Latin America, Middle East, Africa, Central and Eastern Europe and Turkey.
(d)	Lipitor lost exclusivity in various international markets in 2011 and 2012. This loss of exclusivity reduced branded international revenues by $636 million in the fourth quarter of 2012, in comparison with the fourth quarter of 2011.
(e)	Represents direct sales under license agreement with Eisai Co., Ltd.
(f)	Includes Enbrel (in Canada), Aricept, Exforge, Rebif and Spiriva.
(g)	Includes sales of generic atorvastatin. All other established products is a subset of All other biopharmaceutical products.
Certain amounts and percentages may reflect rounding adjustments.

PFIZER INC. REVENUES TWELVE MONTHS 2012 and 2011 (UNAUDITED) (millions of dollars)
	WORLDWIDE								UNITED STATES						TOTAL INTERNATIONAL^(a)
					% Change								% Change						% Change
	2012			2011	Total		Oper.		2012			2011	Total		2012			2011	Total		Oper.
TOTAL REVENUES	$	58,986	$	65,259	(10	%)	(8	%)	$	23,086	$	26,933	(14	%)	$	35,900	$	38,326	(6	%)	(2	%)
REVENUES FROM BIOPHARMACEUTICAL PRODUCTS:	$	51,214	$	57,747	(11	%)	(9	%)	$	19,708	$	23,707	(17	%)	$	31,506	$	34,040	(7	%)	(4	%)
Lyrica		4,158		3,693	13	%	16	%		1,672		1,514	10	%		2,486		2,179	14	%	19	%
Lipitor^(b)		3,948		9,577	(59	%)	(58	%)		932		5,003	(81	%)		3,016		4,574	(34	%)	(33	%)
Enbrel (Outside the U.S. and Canada)		3,737		3,666	2	%	8	%		-		-	-			3,737		3,666	2	%	8	%
Prevnar 13/Prevenar 13		3,718		3,657	2	%	4	%		1,887		1,928	(2	%)		1,831		1,729	6	%	10	%
Celebrex		2,719		2,523	8	%	9	%		1,745		1,597	9	%		974		926	5	%	8	%
Viagra		2,051		1,981	4	%	5	%		1,135		1,003	13	%		916		978	(6	%)	(3	%)
Norvasc		1,349		1,445	(7	%)	(6	%)		48		23	109	%		1,301		1,422	(9	%)	(8	%)
Zyvox		1,345		1,283	5	%	8	%		665		640	4	%		680		643	6	%	11	%
Sutent		1,236		1,187	4	%	9	%		337		307	10	%		899		880	2	%	8	%
Premarin family		1,073		1,013	6	%	7	%		977		915	7	%		96		98	(2	%)	5	%
Genotropin		832		889	(6	%)	(4	%)		204		205	-			628		684	(8	%)	(4	%)
Xalatan/Xalacom		806		1,250	(36	%)	(33	%)		38		176	(78	%)		768		1,074	(28	%)	(26	%)
BeneFIX		775		693	12	%	14	%		358		301	19	%		417		392	6	%	11	%
Detrol/Detrol LA		761		883	(14	%)	(13	%)		486		557	(13	%)		275		326	(16	%)	(13	%)
Vfend		754		747	1	%	5	%		89		86	3	%		665		661	1	%	5	%
Chantix/Champix		670		720	(7	%)	(6	%)		313		326	(4	%)		357		394	(9	%)	(7	%)
Pristiq		630		577	9	%	10	%		493		474	4	%		137		103	33	%	37	%
Refacto AF/Xyntha		584		506	15	%	20	%		106		97	9	%		478		409	17	%	23	%
Zoloft		541		573	(6	%)	(4	%)		68		63	8	%		473		510	(7	%)	(5	%)
Revatio		534		535	-		2	%		312		312	-			222		223	-		5	%
Medrol		523		510	3	%	5	%		140		152	(8	%)		383		358	7	%	10	%
Zosyn/Tazocin		484		636	(24	%)	(22	%)		217		344	(37	%)		267		292	(9	%)	(5	%)
Zithromax/Zmax		435		453	(4	%)	(3	%)		12		20	(40	%)		423		433	(2	%)	(1	%)
Effexor		425		678	(37	%)	(35	%)		109		242	(55	%)		316		436	(28	%)	(24	%)
Prevnar/Prevenar (7-valent)		399		488	(18	%)	(16	%)		-		-	-			399		488	(18	%)	(16	%)
Fragmin		381		382	-		4	%		42		43	(2	%)		339		339	-		5	%
Relpax		368		341	8	%	10	%		219		193	13	%		149		148	1	%	5	%
Rapamune		346		372	(7	%)	(4	%)		185		188	(2	%)		161		184	(13	%)	(7	%)
Cardura		338		380	(11	%)	(9	%)		5		5	-			333		375	(11	%)	(9	%)
Tygacil		335		298	12	%	16	%		152		148	3	%		183		150	22	%	30	%
Aricept^(c)		326		450	(28	%)	(25	%)		-		-	-			326		450	(28	%)	(25	%)
Xanax XR		274		306	(10	%)	(5	%)		50		52	(4	%)		224		254	(12	%)	(6	%)
BMP2		263		340	(23	%)	(23	%)		263		323	(19	%)		-		17	(100	%)	(98	%)
Sulperazon		262		218	20	%	19	%		-		-	-			262		218	20	%	19	%
Diflucan		259		265	(2	%)	1	%		4		5	(20	%)		255		260	(2	%)	1	%
Caduet		258		538	(52	%)	(52	%)		33		272	(88	%)		225		266	(15	%)	(14	%)
Neurontin		235		289	(19	%)	(16	%)		48		63	(24	%)		187		226	(17	%)	(14	%)
Dalacin/Cleocin		232		192	21	%	24	%		90		49	84	%		142		143	(1	%)	4	%
Unasyn		228		231	(1	%)	-			2		6	(67	%)		226		225	-		2	%
Metaxalone/Skelaxin^(d)		223		203	10	%	10	%		223		203	10	%		-		-	-		-
Inspra		214		195	10	%	15	%		5		4	25	%		209		191	9	%	15	%
Toviaz		207		187	11	%	14	%		113		99	14	%		94		88	7	%	13	%
Somavert		197		183	8	%	14	%		46		39	18	%		151		144	5	%	13	%
Alliance revenues^(e)		3,492		3,630	(4	%)	(3	%)		2,620		2,227	18	%		872		1,403	(38	%)	(37	%)
All other biopharmaceutical products^(f)		8,289		8,584	(3	%)	(1	%)		3,265		3,503	(7	%)		5,024		5,081	(1	%)	4	%
All other established products^(f)		6,074		5,671	7	%	10	%		2,165		1,783	21	%		3,909		3,888	1	%	5	%
REVENUES FROM OTHER PRODUCTS:
ANIMAL HEALTH	$	4,299	$	4,184	3	%	6	%	$	1,771	$	1,648	7	%	$	2,528	$	2,536	-		5	%
CONSUMER HEALTHCARE	$	3,212	$	3,028	6	%	8	%	$	1,526	$	1,490	2	%	$	1,686	$	1,538	10	%	13	%
OTHER^(g)	$	261	$	300	(13	%)	(12	%)	$	81	$	88	(8	%)	$	180	$	212	(15	%)	(13	%)

(a)	Total International represents Developed Europe region + Developed Rest of World region + Emerging Markets region. Details for these regions are located on the following page.
(b)	Lipitor lost exclusivity in the U.S. in November 2011 and various other major markets in 2011 and 2012. This loss of exclusivity reduced branded worldwide revenues by $5.6 billion in 2012, in comparison with 2011.
(c)	Represents direct sales under license agreement with Eisai Co., Ltd.
(d)	Legacy King product. King's operations are included in our financial statements commencing from the acquisition date of January 31, 2011.
(e)	Includes Enbrel (in the U.S. and Canada), Aricept, Exforge, Rebif and Spiriva.
(f)	Includes sales of generic atorvastatin. All other established products is a subset of All other biopharmaceutical products.
(g)	Includes revenues generated primarily from Pfizer CentreSource, our contract manufacturing and bulk pharmaceutical chemical sales organization.
Certain amounts and percentages may reflect rounding adjustments.

PFIZER INC. REVENUES DETAIL OF INTERNATIONAL REVENUES BY GEOGRAPHIC REGION TWELVE MONTHS 2012 and 2011 (UNAUDITED) (millions of dollars)
	DEVELOPED EUROPE^(a)								DEVELOPED REST OF WORLD^(b)								EMERGING MARKETS^(c)
					% Change								% Change								% Change
	2012			2011	Total		Oper.		2012			2011	Total		Oper.		2012			2011	Total		Oper.
TOTAL INTERNATIONAL REVENUES	$	13,375	$	16,099	(17	%)	(11	%)	$	10,554	$	10,975	(4	%)	(4	%)	$	11,971	$	11,252	6	%	12	%
REVENUES FROM BIOPHARMACEUTICAL PRODUCTS - INTERNATIONAL:	$	12,010	$	14,737	(19	%)	(13	%)	$	9,536	$	10,008	(5	%)	(5	%)	$	9,960	$	9,295	7	%	12	%
Lyrica		1,319		1,255	5	%	12	%		743		569	31	%	31	%		424		355	19	%	26	%
Lipitor^(d)		1,149		2,400	(52	%)	(50	%)		978		1,315	(26	%)	(26	%)		889		859	3	%	5	%
Enbrel (Outside Canada)		2,318		2,387	(3	%)	4	%		555		524	6	%	5	%		864		755	14	%	23	%
Prevnar 13/Prevenar 13		704		744	(5	%)	1	%		266		241	10	%	11	%		861		744	16	%	18	%
Celebrex		161		182	(12	%)	(4	%)		479		431	11	%	12	%		334		313	7	%	11	%
Viagra		370		400	(8	%)	(3	%)		201		212	(5	%)	(4	%)		345		366	(6	%)	(2	%)
Norvasc		119		165	(28	%)	(22	%)		659		773	(15	%)	(16	%)		523		484	8	%	9	%
Zyvox		302		306	(1	%)	6	%		154		149	3	%	4	%		224		188	19	%	26	%
Sutent		439		468	(6	%)	1	%		176		169	4	%	4	%		284		243	17	%	26	%
Premarin family		10		10	-		-			36		34	6	%	9	%		50		54	(7	%)	2	%
Genotropin		295		356	(17	%)	(12	%)		224		221	1	%	-			109		107	2	%	8	%
Xalatan/Xalacom		275		509	(46	%)	(42	%)		311		369	(16	%)	(16	%)		182		196	(7	%)	-
BeneFIX		248		255	(3	%)	4	%		137		113	21	%	21	%		32		24	33	%	33	%
Detrol/Detrol LA		119		157	(24	%)	(21	%)		102		109	(6	%)	(6	%)		54		60	(10	%)	(3	%)
Vfend		281		304	(8	%)	(1	%)		162		153	6	%	5	%		222		204	9	%	14	%
Chantix/Champix		129		175	(26	%)	(23	%)		179		170	5	%	5	%		49		49	-		8	%
Pristiq		-		-	-		-			90		67	34	%	32	%		47		36	31	%	42	%
Refacto AF/Xyntha		373		374	-		6	%		64		33	94	%	94	%		41		2	*		*
Zoloft		59		81	(27	%)	(22	%)		278		301	(8	%)	(8	%)		136		128	6	%	11	%
Revatio		133		141	(6	%)	1	%		56		47	19	%	17	%		33		35	(6	%)	6	%
Medrol		94		103	(9	%)	(2	%)		48		48	-		-			241		207	16	%	19	%
Zosyn/Tazocin		48		63	(24	%)	(17	%)		13		14	(7	%)	(7	%)		206		215	(4	%)	(1	%)
Zithromax/Zmax		59		80	(26	%)	(21	%)		186		184	1	%	(1	%)		178		169	5	%	7	%
Effexor		110		181	(39	%)	(35	%)		102		155	(34	%)	(34	%)		104		100	4	%	9	%
Prevnar/Prevenar (7-valent)		-		23	(100	%)	(100	%)		346		358	(3	%)	(5	%)		53		107	(50	%)	(39	%)
Fragmin		182		178	2	%	8	%		84		77	9	%	9	%		73		84	(13	%)	(6	%)
Relpax		70		76	(8	%)	(1	%)		60		56	7	%	9	%		19		16	19	%	25	%
Rapamune		54		60	(10	%)	(3	%)		18		18	-		-			89		106	(16	%)	(8	%)
Cardura		97		119	(18	%)	(13	%)		134		155	(14	%)	(14	%)		102		101	1	%	6	%
Tygacil		67		64	5	%	14	%		7		6	17	%	17	%		109		80	36	%	44	%
Aricept^(e)		110		229	(52	%)	(49	%)		177		170	4	%	6	%		39		51	(24	%)	(18	%)
Xanax XR		89		107	(17	%)	(10	%)		44		50	(12	%)	(10	%)		91		97	(6	%)	2	%
BMP2		-		17	(100	%)	(100	%)		-		-	-		-			-		-	-		-
Sulperazon		-		-	-		-			36		42	(14	%)	(16	%)		226		176	28	%	27	%
Diflucan		60		80	(25	%)	(19	%)		41		47	(13	%)	(13	%)		154		133	16	%	18	%
Caduet		14		18	(22	%)	(17	%)		149		189	(21	%)	(22	%)		62		59	5	%	8	%
Neurontin		58		76	(24	%)	(18	%)		45		57	(21	%)	(23	%)		84		93	(10	%)	(5	%)
Dalacin/Cleocin		32		35	(9	%)	(3	%)		26		27	(4	%)	-			84		81	4	%	10	%
Unasyn		39		34	15	%	24	%		76		81	(6	%)	(9	%)		111		110	1	%	3	%
Metaxalone/Skelaxin^(f)		-		-	-		-			-		-	-		-			-		-	-		-
Inspra		131		126	4	%	12	%		61		51	20	%	18	%		17		14	21	%	29	%
Toviaz		76		71	7	%	14	%		8		8	-		13	%		10		9	11	%	11	%
Somavert		123		121	2	%	10	%		17		14	21	%	23	%		11		9	22	%	33	%
Alliance revenues^(g)		242		536	(55	%)	(52	%)		565		785	(28	%)	(29	%)		65		82	(21	%)	(12	%)
All other biopharmaceutical products^(h)		1,452		1,671	(13	%)	(7	%)		1,443		1,416	2	%	2	%		2,129		1,994	7	%	14	%
All other established products^(h)		1,050		1,173	(10	%)	(4	%)		1,051		1,094	(4	%)	(4	%)		1,808		1,621	12	%	19	%
REVENUES FROM OTHER PRODUCTS - INTERNATIONAL:	$	1,365	$	1,362	-		7	%	$	1,018	$	967	5	%	6	%	$	2,011	$	1,957	3	%	8	%

* Calculation not meaningful.
(a)	Developed Europe region includes the following markets: Western Europe, Finland and the Scandinavian countries.
(b)	Developed Rest of World region includes the following markets: Australia, Canada, Japan, New Zealand and South Korea.
(c)	Emerging Markets region includes, but is not limited to, the following markets: Asia (excluding Japan and South Korea), Latin America, Middle East, Africa, Central and Eastern Europe and Turkey.
(d)	Lipitor lost exclusivity in various international markets in 2011 and 2012. This loss of exclusivity reduced branded international revenues by $1.6 billion in 2012, in comparison with 2011.
(e)	Represents direct sales under license agreement with Eisai Co., Ltd.
(f)	Legacy King product. King's operations are included in our financial statements commencing from the acquisition date of January 31, 2011.
(g)	Includes Enbrel (in Canada), Aricept, Exforge, Rebif and Spiriva.
(h)	Includes sales of generic atorvastatin. All other established products is a subset of All other biopharmaceutical products.
Certain amounts and percentages may reflect rounding adjustments.

PFIZER INC.
SUPPLEMENTAL INFORMATION

1. Change in Reported Cost of Sales

Reported cost of sales decreased 13% in the fourth quarter and 19% in full-year 2012, compared to the same periods in 2011. The decreases were primarily due to lower purchase accounting adjustments in 2012, lower costs related to our cost-reduction and productivity initiatives and acquisition-related costs, as well as the benefits generated from the ongoing productivity initiatives to streamline the manufacturing network. Additionally, the decreases were due to reduced manufacturing volumes related to products that lost exclusivity in various markets. The decreases were partially offset by the unfavorable impact of a shift in geographic, business and product mix for both periods. In addition, reported cost of sales in fourth-quarter 2012 reflects the unfavorable impact of foreign exchange of 7%, while reported cost of sales in full-year 2012 reflects the favorable impact of foreign exchange of 3%.

Reported cost of sales as a percentage of revenues decreased 1.4 percentage points to 21.1% in the fourth quarter of 2012, compared to the same period in 2011, reflecting the aforementioned factors.

2. Change in Reported Selling, Informational & Administrative (SI&A) Expenses and Reported Research & Development (R&D) Expenses

Reported SI&A expenses decreased 7% in fourth-quarter 2012 and 12% in full-year 2012, compared to the same periods in 2011. The decreases were primarily due to savings generated from a reduction in the field force and a decrease in promotional spending, both partially in response to product losses of exclusivity and more streamlined corporate support functions, as well as the favorable impact of foreign exchange of 1% in the fourth quarter of 2012 and 2% in full-year 2012, partially offset by costs associated with the potential separation of Zoetis employees, net assets and operations from Pfizer.

Reported R&D expenses decreased 17% in fourth-quarter 2012 and 13% in full-year 2012, compared to the same periods in 2011, primarily due to savings generated by the discontinuation of certain therapeutic areas and R&D programs in connection with our previously announced cost-reduction and productivity initiatives, which were partially offset in full-year 2012 by a $250 million payment to AstraZeneca in the third quarter of 2012 to obtain the exclusive global over-the-counter rights to Nexium.

3. Other Deductions – Net

($ in millions)		Fourth-Quarter						Full-Year
		2012			2011			2012			2011
Interest income^(a)	$	(108	)	$	(125	)	$	(383	)	$	(456	)
Interest expense^(a)		373			396			1,524			1,681
Net interest expense		265			271			1,141			1,225
Royalty-related income		(116	)		(122	)		(469	)		(569	)
Net (gain)/loss on asset disposals		(7	)		32			(52	)		(15	)
Certain legal matters, net^(b)		206			165			2,220			784
Certain asset impairment charges^(c)		366			277			927			902
Costs associated with the potential separation of Zoetis^(d)		32			33			125			33
Other, net		2			41			139			139
Other deductions––net	$	748		$	697		$	4,031		$	2,499

(a) Interest income decreased in both periods in 2012 due to lower average cash balances and lower interest rates earned on investments. Interest expense decreased in both periods in 2012 due to lower debt balances and the effective conversion of some fixed-rate liabilities to floating-rate liabilities.

(b) In fourth-quarter 2012, primarily includes charges related to Chantix litigation. In full-year 2012, primarily includes a $491 million charge resulting from an agreement-in-principle with the U.S. Department of Justice to resolve an investigation into Wyeth’s historical promotional practices in connection with Rapamune, a $450 million settlement of a lawsuit by Brigham Young University related to Celebrex, and charges related to hormone-replacement therapy litigation and Chantix litigation. In 2011, primarily includes charges for hormone-replacement therapy litigation.

(c) In fourth-quarter and full-year 2012, primarily relates to certain intangible assets acquired in connection with our acquisitions of Wyeth and King, including in-process research and development (IPR&D) intangible assets. In fourth-quarter 2011, primarily relates to our indefinite-lived brand asset, Xanax, as a result of an increased competitive environment. In full-year 2011, substantially all relates to certain intangible assets acquired in connection with our acquisition of Wyeth, including IPR&D intangible assets, and our indefinite-lived brand asset, Xanax, as mentioned in the previous sentence.

(d) Costs incurred in connection with the potential initial public offering of up to a 19.8% ownership stake in Zoetis. Includes expenditures for banking, legal, accounting and similar services related to the potential transaction.

4. Effective Tax Rate

Reported
The effective tax rate for continuing operations was 31.3% for the fourth quarter of 2012 compared with 34.4% for the fourth quarter of 2011, and 21.2% for full-year 2012 compared with 31.8% for full-year 2011. The lower rates for 2012 compared with the prior-year rates reflect the impact of the change in the jurisdictional mix of earnings and the expiration of the U.S. research and development tax credit. The full-year 2012 effective tax rate was also favorably impacted by a settlement with the U.S. Internal Revenue Service related to audits for multiple tax years and the resolution of foreign audits pertaining to multiple tax years, partially offset by the unfavorable impact of the non-deductibility of a legal charge related to Rapamune, all recorded in third-quarter 2012.

Adjusted
The effective tax rate on adjusted income⁽¹⁾ was 31.0% in fourth-quarter 2012 compared with 29.8% in fourth-quarter 2011, and 29.3% in full-year 2012 compared with 29.6% in full-year 2011. The rates for 2012 compared with the prior-year rates reflect the impact of the change in the jurisdictional mix of earnings and the expiration of the U.S. research and development tax credit. The full-year 2012 effective tax rate compared to the prior-year rate also reflects the favorable impact of the resolution of the aforementioned foreign audits recorded in third-quarter 2012.

5. Reconciliation of 2013 Adjusted Income⁽¹⁾ and Adjusted Diluted EPS⁽¹⁾ Guidance to 2013 Reported Net Income Attributable to Pfizer Inc. and Reported Diluted EPS Attributable to Pfizer Inc. Common Shareholders Guidance^(a)

	Full-Year 2013 Guidance
(Billions of dollars, except per share amounts)	Net Income^(b)		Diluted EPS^(b)
Income/(Expense)
Adjusted Income/Diluted EPS^(1) Guidance^(c)	~$15.4 - $16.1		~$2.20 - $2.30
Purchase Accounting Impacts of Transactions Completed as of 12/31/12	(3.4	)	(0.49	)
Acquisition-Related Costs	(0.4 - 0.5	)	(0.06 - 0.07	)
Non-Acquisition-Related Restructuring Costs^(d)	(0.5 – 0.8	)	(0.08 - 0.12	)
Costs associated with the potential separation of Zoetis^(c)	(0.2	)	(0.02	)
Reported Net Income Attributable to Pfizer Inc./Diluted EPS Guidance^(c)	~$10.5 - $11.6		~$1.50 - $1.65

(a) The exchange rates assumed in connection with the 2013 financial guidance are as of mid-January 2013.

(b) Does not assume the completion of any business development transactions not completed as of December 31, 2012, including any one-time upfront payments associated with such transactions, and excludes the potential effects of the resolution of litigation-related matters not substantially resolved as of December 31, 2012.

(c) The 2013 financial guidance reflects the benefit of a full-year contribution from Zoetis. Adjusted⁽¹⁾ and Reported Diluted EPS guidance includes a $0.02 unfavorable impact for Zoetis-related interest expense and certain duplicative and other costs given its potential separation. Reported Diluted EPS guidance includes an additional $0.02 unfavorable impact for costs related to the establishment of Zoetis’ corporate and manufacturing support functions, and certain other costs related to the potential separation of Zoetis from Pfizer, including new branding, creation of a standalone infrastructure, site separation and certain legal registration and patent assignment costs.

(d) Includes amounts related to our initiatives to reduce R&D spending, including our realigned R&D footprint, and amounts related to other cost-reduction and productivity initiatives. These amounts are included in Certain Significant Items.

______________________________________________

(1) “Adjusted income” and “adjusted diluted earnings per share (EPS)” are defined as reported U.S. generally accepted accounting principles (GAAP) net income attributable to Pfizer Inc. and reported diluted EPS attributable to Pfizer Inc. common shareholders excluding purchase accounting adjustments, acquisition-related costs, discontinued operations and certain significant items. As described under Adjusted Income in the Management’s Discussion and Analysis of Financial Condition and Results of Operations section of Pfizer’s Form 10-Q for the fiscal quarter ended September 30, 2012, management uses Adjusted income, among other factors, to set performance goals and to measure the performance of the overall company. We believe that investors’ understanding of our performance is enhanced by disclosing this measure. The Adjusted income and Adjusted diluted EPS measures are not, and should not be viewed as substitutes for U.S. GAAP net income and diluted EPS.

DISCLOSURE NOTICE: The information contained in this earnings release and the attachments is as of January 29, 2013. We assume no obligation to update forward-looking statements contained in this earnings release and the attachments as a result of new information or future events or developments.

This earnings release and the attachments contain forward-looking statements about our future operating and financial performance, business plans and prospects, in-line products and product candidates, strategic review, capital allocation, business development plans, and share-repurchase and dividend-rate plans that involve substantial risks and uncertainties. You can identify these statements by the fact that they use future dates or use words such as “will,” “anticipate,” “estimate,” “expect,” “project,” “intend,” “plan,” “believe,” “target,” “forecast,” “goal,” “objective,” “aim” and other words and terms of similar meaning. Among the factors that could cause actual results to differ materially from past results and future plans and projected future results are the following:

• the outcome of research and development activities, including, without limitation, the ability to meet anticipated clinical trial commencement and completion dates, regulatory submission and approval dates, and launch dates for product candidates;
• decisions by regulatory authorities regarding whether and when to approve our drug applications, as well as their decisions regarding labeling, ingredients and other matters that could affect the availability or commercial potential of our products;
• the speed with which regulatory authorizations, pricing approvals and product launches may be achieved;
• the outcome of post-approval clinical trials, which could result in the loss of marketing approval for a product or changes in the labeling for, and/or increased or new concerns about the safety or efficacy of, a product that could affect its availability or commercial potential;
• the success of external business-development activities;
• competitive developments, including the impact on our competitive position of new product entrants, in-line branded products, generic products, private label products and product candidates that treat diseases and conditions similar to those treated by our in-line drugs and drug candidates;
• the implementation by the FDA of an abbreviated legal pathway to approve biosimilar products, which could subject our biologic products to competition from biosimilar products in the U.S., with attendant competitive pressures, after the expiration of any applicable exclusivity period and patent rights;
• the ability to meet generic and branded competition after the loss of patent protection for our products or competitor products;
• the ability to successfully market both new and existing products domestically and internationally;
• difficulties or delays in manufacturing;
• trade buying patterns;
• the impact of existing and future legislation and regulatory provisions on product exclusivity;
• trends toward managed care and healthcare cost containment;
• the impact of the U.S. Budget Control Act of 2011 (the Budget Control Act) and the deficit-reduction actions to be taken pursuant to the Budget Control Act in order to achieve the deficit-reduction targets provided for therein, and the impact of any broader deficit-reduction efforts;
• the possible failure of the federal government to increase or suspend the federal debt ceiling and any resulting inability of the federal government to satisfy its financial obligations, including under Medicare, Medicaid and other publicly funded or subsidized health programs;
• the impact of U.S. healthcare legislation enacted in 2010 -- the Patient Protection and Affordable Care Act, as amended by the Health Care and Education Reconciliation Act -- and of any modification or repeal of any of the provisions thereof;
• U.S. legislation or regulatory action affecting, among other things: pharmaceutical product pricing, reimbursement or access, including under Medicaid, Medicare and other publicly funded or subsidized health programs; the importation of prescription drugs from outside the U.S. at prices that are regulated by governments of various foreign countries; direct-to-consumer advertising and interactions with healthcare professionals; and the use of comparative effectiveness methodologies that could be implemented in a manner that focuses primarily on the cost differences and minimizes the therapeutic differences among pharmaceutical products and restricts access to innovative medicines;
• legislation or regulatory action in markets outside the U.S. affecting pharmaceutical product pricing, reimbursement or access, including, in particular, continued government-mandated price reductions for certain biopharmaceutical products in certain European and emerging market countries;
• the exposure of our operations outside the U.S. to possible capital and exchange controls, expropriation and other restrictive government actions, changes in intellectual property legal protections and remedies, as well as political unrest and unstable governments and legal systems;
• contingencies related to actual or alleged environmental contamination;
• claims and concerns that may arise regarding the safety or efficacy of in-line products and product candidates;
• any significant breakdown, infiltration, or interruption of our information technology systems and infrastructure;
• legal defense costs, insurance expenses, settlement costs, the risk of an adverse decision or settlement and the adequacy of reserves related to product liability, patent protection, government investigations, consumer, commercial, securities, antitrust, environmental and tax issues, ongoing efforts to explore various means for resolving asbestos litigation, and other legal proceedings;
• our ability to protect our patents and other intellectual property, both domestically and internationally;
• interest rate and foreign currency exchange rate fluctuations;
• governmental laws and regulations affecting domestic and foreign operations, including, without limitation, tax obligations and changes affecting the tax treatment by the U.S. of income earned outside of the U.S. that may result from pending and possible future proposals;
• any significant issues involving our largest wholesaler customers, which account for a substantial portion of our revenues;
• the possible impact of the increased presence of counterfeit medicines in the pharmaceutical supply chain on our revenues and on patient confidence in the integrity of our medicines;
• any significant issues that may arise related to the outsourcing of certain operational and staff functions to third parties, including with regard to quality, timeliness and compliance with applicable legal requirements and industry standards;
• changes in U.S. generally accepted accounting principles;
• uncertainties related to general economic, political, business, industry, regulatory and market conditions including, without limitation, uncertainties related to the impact on us, our customers, suppliers and lenders and counterparties to our foreign-exchange and interest-rate agreements of challenging global economic conditions and recent and possible future changes in global financial markets; and the related risk that our allowance for doubtful accounts may not be adequate;
• any changes in business, political and economic conditions due to actual or threatened terrorist activity in the U. S. and other parts of the world, and related U. S. military action overseas;
• growth in costs and expenses;
• changes in our product, segment and geographic mix;
• the possibility that the potential initial public offering (IPO) of up to a 19.8% ownership stake in Zoetis Inc., for which a registration statement has been filed with the Securities and Exchange Commission, will not be consummated at all or within the anticipated time period or at a price within the estimated IPO range, including as the result of regulatory, market or other factors; and, if the IPO is consummated, the impact of the strategic alternative that we decide to pursue with regard to our remaining ownership stake in Zoetis Inc.; and
• the impact of acquisitions, divestitures, restructurings, product recalls and withdrawals and other unusual items, including our ability to realize the projected benefits of our cost-reduction and productivity initiatives, including those related to our research and development organization.

A further list and description of risks, uncertainties and other matters can be found in our Annual Report on Form 10-K for the fiscal year ended December 31, 2011 and in our reports on Form 10-Q, in each case including in the sections thereof captioned “Forward-Looking Information and Factors That May Affect Future Results” and “Item 1A. Risk Factors”, and in our reports on Form 8-K.

This earnings release may include discussion of certain clinical studies relating to various in-line products and/or product candidates. These studies typically are part of a larger body of clinical data relating to such products or product candidates, and the discussion herein should be considered in the context of the larger body of data.

This earnings release does not constitute an offer to sell, or a solicitation of an offer to buy, any securities, which will be made only by prospectus.