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赜灵生物宣布啟動馬來酸氟諾替尼治療骨髓纖維化的國際隨機研究,並將於2026年美國血液學會(ASH)年會上發表相關研究成果

中國,成都--(BUSINESS WIRE)--(美國商業資訊)-- 成都赜灵生物医药科技股份有限公司(赜灵生物/Zenitar)正在開發的馬來酸氟諾替尼(FM)是一種首創的口服JAK2/FLT3/CDK6抑制劑,用於治療骨髓增生性腫瘤(MPN),包括骨髓纖維化(MF)和真性紅血球增多症(PV)。 Zenitar在美國、加拿大和巴西啟動了隨機II期臨床試驗FM-MF-02(NCT07750574),旨在為JAK抑制劑初治和難治性MF患者選擇III期臨床試驗劑量。隨機試驗FMF-02(NCT06457425)已達到第24週研究終點:與蘆可替尼相比,FM 50mg和100mg兩個劑量組在SVR35和TSS50方面均表現更佳,先前的資料已在美國血液學會2024年會(#486)和2025年會(#908)上進行口頭報告。在2026年ASH年會上,Zenitar將公布FMF-02研究的長期追蹤結果(口頭報告,#411,12月12日下午4:30)和難治性PV II期資料(海報展示,#3765,12月13日下午6:00),兩項報告均歸屬於ASH第634專題。 「自蘆可替尼首次獲得FDA批准以來的15年...
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赜灵生物宣布启动马来酸氟诺替尼治疗骨髓纤维化的国际随机研究,并将在2026年美国血液学会(ASH)年会上公布相关研究成果

中国,成都--(BUSINESS WIRE)--(美国商业资讯)-- 成都赜灵生物医药科技股份有限公司(赜灵生物/Zenitar)正在开发马来酸氟诺替尼(flonoltinib maleate,FM)。FM是一款同类首创的口服JAK2/FLT3/CDK6抑制剂,旨在治疗骨髓增殖性肿瘤(MPN),包括骨髓纤维化(MF)和真性红细胞增多症(PV)。 Zenitar已在美国、加拿大和巴西启动Ⅱ期随机研究FM-MF-02(NCT07750574),旨在为后续针对既往未接受过JAK抑制剂(JAKi)治疗的MF患者及难治性MF患者开展的Ⅲ期研究确定剂量。随机研究FMF-02(NCT06457425)已达到第24周研究终点:FM 50毫克和100毫克剂量组在脾脏体积缩小至少35%的应答率(SVR35)和总症状评分降低至少50%的应答率(TSS50)方面均优于芦可替尼。此前的数据已分别在2024年和2025年美国血液学会(ASH)年会上以口头报告形式公布,摘要编号分别为486和908。在2026年ASH年会上,Zenitar将公布FMF-02研究的长期随访结果(口头报告,摘要编号411,12月12日下...
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Discover Network and Diners Club International Announce Strategic Payments Partnership with Merlin Entertainments to Enhance Visitor Experience

LONDON & RIVERWOODS, Ill.--(BUSINESS WIRE)--Discover® Network, Diners Club International® and Merlin Entertainments today announced a comprehensive partnership designed to provide seamless payment experiences for millions of guests at some of their most iconic London attractions, as well as across their entire worldwide portfolio. Merlin Entertainments, the global family of destinations, experiences and attractions, has been dedicated to accelerating growth by building deeper guest relationship...
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Cadeler Opens Rotterdam Office to Strengthen European Offshore Wind Operations

ROTTERDAM, The Netherlands--(BUSINESS WIRE)--Cadeler, a key partner in offshore wind transportation and installation, has opened a new office in Rotterdam, strengthening its presence in one of Europe’s leading maritime and offshore wind hubs. The office will house operations, engineering and technical teams supporting the company’s activities in the Netherlands and beyond. With its established maritime and offshore industry cluster, Rotterdam provides access to specialist expertise, industry pa...
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Nano One Commences Construction for Candiac Expansion, Provides Update on Commercial Activities

VANCOUVER, British Columbia--(BUSINESS WIRE)--Nano One® Materials Corp. ("Nano One" or the "Company") (TSX: NANO) (OTCQB: NNOMF) (Frankfurt: LBMB), a process technology company specializing in lithium-ion battery cathode active materials (CAM), provides an update on its Candiac Facility expansion and commercial activities. Candiac Expansion Advancing to Construction Detailed engineering for the Candiac Facility expansion project was completed at the end of September 2026. Construction is now un...
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Nano One débute la construction pour l'expansion de Candiac et fournit une mise à jour sur les activités commerciales

VANCOUVER, British Columbia--(BUSINESS WIRE)--Nano One® Materials Corp. (« Nano One » ou la « Compagnie ») (TSX : NANO) (OTCQB : NNOMF) (Francfort : LBMB), une entreprise de technologie de procédé spécialisée dans les matériaux actifs de cathode (CAM) pour batteries lithium-ion, fournit une mise à jour sur l'expansion de ses installations à Candiac et ses activités commerciales. L'expansion de Candiac progresse, la construction débute L'ingénierie détaillée du projet d'expansion de l'installati...
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Wells Fargo Study Finds Veterans Report Greater Career Satisfaction, Financial Confidence and Optimism About AI

SAN FRANCISCO--(BUSINESS WIRE)--Wells Fargo survey finds veterans report stronger career satisfaction, financial confidence and optimism about AI....
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Clean Food Group and Raven Botanicals Partner for World-First Commercial Launch of Fermentation-Derived CLEANOil™ in Skincare

LONDON--(BUSINESS WIRE)--Clean Food Group (‘CFG’), a leading UK biotech manufacturer pioneering sustainable oils and fats through fermentation, announces the commercial debut of its sustainable, fermentation-derived triglyceride oil, CLEANOil™, in the consumer beauty market. Its use in Scottish skincare brand Raven Botanicals’ award-winning 24 Carat Oil to Milk Cleanser marks the culmination of three years’ work to bring high-performance, sustainable biotechnology from the laboratory into every...
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Festo, Softcat, ANS Group and SCC Demonstrate the Business Impact of AI-Powered Observability

LONDON--(BUSINESS WIRE)--LogicMonitor®, the AI-first platform for Autonomous IT, announced the 2026 Elevate Award winners today at its Elevate Community Conference in London. The annual awards recognize LogicMonitor customers and partners that are achieving measurable business and operational outcomes through AI-powered observability. From consolidating 90% of monitoring tools and reducing alert noise by 85% to cutting observability case volumes by 45%, this year's EMEA winners demonstrate how...
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Western Tungsten Prices Trade at 3.74 Times China's, MetalMiner Finds

CHICAGO--(BUSINESS WIRE)--The Western and Chinese tungsten markets have split, and the gap is now a cost that anyone financing, contracting for, or stockpiling the metal must price in. On Oct. 26, 2026, Rotterdam warehouse ammonium paratungstate (APT) traded at $278.22 per kilogram, 3.74 times China ex-works APT at $74.43, against an average multiple of 1.24 from September 2021 to June 2025, according to a new MetalMiner white paper. The paper, "Tungsten Resilience Intelligence: Integrating Str...