CAR-T Pipeline Insights Report 2020: Comprehensive Insights on 250+ Companies and Pipeline Drugs - ResearchAndMarkets.com

DUBLIN--()--The "CAR-T - Pipeline Insight, 2020" drug pipelines has been added to ResearchAndMarkets.com's offering.

The CAR-T - Pipeline Insight, 2020, report provides comprehensive insights about 250+ companies and 250+ pipeline drugs in CAR-T pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

CAR-T: Overview

CAR-T is a type of treatment in which a patient's T cells (a type of immune system cell) are changed in the laboratory so they will attack cancer cells. T cells are taken from a patient's blood. Then the gene for a special receptor that binds to a certain protein on the patient's cancer cells is added to the T cells in the laboratory. The special receptor is called a chimeric antigen receptor (CAR). Large numbers of the CAR T cells are grown in the laboratory and given to the patient by infusion. CAR T-cell therapy is used to treat certain blood cancers, and it is being studied in the treatment of other types of cancer. Also called chimeric antigen receptor T-cell therapy.

Potential Mechanisms of CAR-T Cell-Mediated Toxicity

Significant progress has been made in the field of cancer immunotherapy, and CAR-T cells have shown outstanding efficacy in clinical trials. As with all technologies, CAR-T technologies also need to go through a long process of development, and CAR-T cell therapy has related acute and chronic toxicities that have become a roadblock on the developmental path. If these setbacks are not overcome, it will be difficult to make a more significant breakthrough.

Cytokine Release Syndrome

Cytokine release syndrome (CRS) is the most common toxic side effect in CAR-T cell therapy. CRS is a systemic inflammatory response caused by the significant increase in cytokines accompanied by the rapid in vivo activation and proliferation of CAR-T cells, usually occurring within a few days after the first infusion. CRS is a clinical condition with mild symptoms of fever, fatigue, headache, rash, joint pain, and myalgia. Severe CRS cases are characterized by tachycardia, hypotension, and high fever. Mild to moderate CRS is usually self-limiting and can be managed through close observation and supportive care. Severe CRS must be treated with tocilizumab or steroids alone for intensive treatment.

Advances in Research of CAR-T Cell Therapy for Solid Tumors

Although early CAR-T cell trials of solid tumors did not show the same success as observed in leukemia trials, a better understanding of the multiple barriers seen in solid tumors could promote the design of clinical trials for CAR-T cells. In this early stage of clinical development, CAR-T cells offer much hope. The ability of genetic manipulation techniques to modify CAR-T cells provides almost unlimited opportunities for other changes and improvements, thus providing a strong desire for future success.

Global Landscape of CAR-T Cell Therapy

At present, CAR-T cells are widely used in cellular immunotherapy for various tumors. According to statistics, more than 300 clinical trials of CAR-T cell therapies have been approved by many national drug regulatory agencies, including the FDA of the United States. Statistical data from these clinical trials show that although the effects of various clinical trials vary due to the use of different sources and the preparation techniques of CARs and T cells, as well as differences in pretreatment and combinations of drugs, overall, CAR-T cells are effective in treating tumors with an effective rate of 30% to 70% or even more than 90%. For example, the complete remission rate for r/r ALL treated with the Novartis drug CTL0l9, which the FDA has approved, is 93%. Perhaps CAR-T cell therapy will ultimately remedy the fate of human cancer.

CAR-T Emerging Drugs Chapters

This segment of the CAR-T report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Key Players

  • AbbVie Inc.
  • Adaptimmune Therapeutics PLC.
  • Amgen, Inc.
  • Atara Biotherapeutics, Inc.
  • Aurora Biopharma, Inc.
  • Autolus Therapeutics PLC.
  • Bellicum Pharmaceuticals, Inc.
  • BioAtla LLC.
  • bluebird bio
  • Carina Biotech
  • CARsgen Therapeutics, Ltd.
  • CARTherics
  • Celgene
  • Cellectis
  • Celularity
  • Celyad SA
  • Creative Biolabs
  • DiaCarta, Inc.
  • Endocyte, Inc.
  • F1 Oncology, Inc.
  • Fate Therapeutics Inc.
  • Gilead
  • Humanigen, Inc.
  • Immune Therapeutics, Inc.
  • Intrexon, Corp.
  • Juno Therapeutics, Inc.
  • Kite Pharma, Inc.
  • Lion TCR Pte Ltd.
  • MaxCyte, Inc.
  • Mesoblast, Ltd.
  • Minerva Biotechnologies Corp.
  • Mustang Bio, Inc.
  • Novartis AG
  • Oxford BioMedica PLC.
  • PeproMene Bio Inc.
  • Pfizer, Inc.
  • Posedia Therapeutics Inc.
  • Precision Biosciences, Inc.
  • ProMab Biotechnologies Inc.
  • Servier Oncology
  • Sorrento Therapeutics, Inc.
  • TC Biopharm Ltd.
  • Tessa Therapeutics Pte Ltd.
  • TILT Biotherapeutics Ltd.
  • Tmunity Therapeutics Inc.
  • TrakCel Ltd.
  • Xyphos
  • ZIOPHARM Oncology, Inc.

Key Products

  • LCAR-B38M CAR-T Cell
  • Anti-CEA CAR-T cells
  • CD30.CAR-T
  • AUTO CAR T cell therapy
  • Defibrotide
  • MB-CART2019.1 Dose level 1
  • CAR-T
  • CD19/22 CART
  • JNJ-68284528
  • CD123 CAR-T cells
  • CD19 CAR-T cells
  • BCMA CAR-T cells
  • CEA CAR-T cells
  • CAR-T cell immunotherapy
  • Autologous CAR-T cells
  • Second generation CAR-T cells
  • CAR-T/TCR-T cells immunotherapy
  • Allogeneic hematological stem cell transplantation
  • Humanized CD19 CAR-T cells
  • CD19 CART
  • MB-CART20.1
  • MB-CART19.1
  • IM19 CAR-T Cells
  • CLDN6 CAR-T
  • Autologous CD19-targeting CAR T cells
  • P-BCMA-101 CAR-T cells
  • MLM-CAR44.1 T-cells, cyclophosphamide and fludarabine from -5 to -3
  • CART-19/22
  • Anakinra
  • Anti-MUC1 CAR-T cells
  • CAR T-cell therapy
  • CAR T cells
  • CART-19
  • CAR-CD19 T Cells
  • CAR-BCMA T Cells
  • LCAR-B38M CAR-T cell injection
  • AUTO1
  • AUTO3
  • Gene-modified (GM) T cell therapy
  • Descartes-08
  • iC9-CAR19 cells
  • ALLO-501A

For more information about this drug pipelines report visit https://www.researchandmarkets.com/r/fja6gn

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Contacts

ResearchAndMarkets.com
Laura Wood, Senior Press Manager
press@researchandmarkets.com
For E.S.T Office Hours Call 1-917-300-0470
For U.S./CAN Toll Free Call 1-800-526-8630
For GMT Office Hours Call +353-1-416-8900