Entrectinib (Roche/Chugai/Nerviano): Global Drug Overview & Outlook with Sales for Non-small Cell Lung Cancer (NSCLC) by Country 2017-2026 - ResearchAndMarkets.com

DUBLIN--()--The "Entrectinib" report has been added to ResearchAndMarkets.com's offering.

Entrectinib (Roche/Chugai/Nerviano) is a selective tyrosine kinase inhibitor (TKI) of the tropomyosin receptor kinases (Trk) A, B, and C; ROS1; and anaplastic lymphoma kinase (ALK) proteins.

Under normal conditions, these oncogenes regulate the flow of cellular growth signaling. However, mutations or molecular alterations can result in overactivity, setting off a signal cascade that drives uncontrolled proliferation. Entrectinib binds to and inhibits TrkA, TrkB, TrkC, ROS1, and ALK, disrupting signaling and thereby leading to an induction of apoptosis and an inhibition of tumor cell proliferation in tumor cells that express these kinases. In vivo models of entrectinib in TrkB expressing neuroblastoma cells suggest that the drug may enhance the efficacy of conventional chemotherapy.

Key Topics Covered

  1. Drug Overview
  2. Product Profiles
  3. Entrectinib: Non-small cell lung cancer (NSCLC)

List of Figures

Figure 1: The authors drug assessment summary for Cyramza in non-small cell lung cancer

Figure 2: The authors drug assessment summary for entrectinib in non-small cell lung cancer

Figure 3: Entrectinib sales for NSCLC across the US, Japan, and five major EU markets, by country, 2017-26

List of Tables

Table 1: Entrectinib pivotal trial data in non-small cell lung cancer

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Related Topics: Lymphoma Drugs

Contacts

ResearchAndMarkets.com
Laura Wood, Senior Press Manager
press@researchandmarkets.com
For E.S.T Office Hours Call 1-917-300-0470
For U.S./CAN Toll Free Call 1-800-526-8630
For GMT Office Hours Call +353-1-416-8900
Related Topics: Lymphoma Drugs