Adcirca (tadalafil; Eli Lilly/United Therapeutics/Nippon Shinyaku) Drug Overview & Product Profile 2016-2025 - ResearchAndMarkets.com

DUBLIN--()--The "Adcirca" report has been added to ResearchAndMarkets.com's offering.

Launching after Revatio, Adcirca became the second-to-market PDE5 inhibitor upon its approval in major markets in 2009. Inhibiting the PDE5 enzyme enhances the effect of the endogenous vasodilator, nitric oxide (NO). The extracellular vasodilator NO activates cellular guanylate cyclase, which in turn increases cyclic guanosine monophosphate (cGMP) concentrations, leading to smooth muscle cell vasorelaxation. PDE5 rapidly degrades cGMP, and by inhibiting the cGMP-specific PDE5 enzyme, Adcirca inhibits the degradation of cGMP, which enhances NO-induced vasodilation (Barnett and Machado, 2006).

Analyst Outlook

Adcirca (tadalafil; Eli Lilly/United Therapeutics/Nippon Shinyaku) now faces generic competition across the US and five major EU markets (France, Germany, Italy, Spain, and the UK). While Adcirca's historical sales have exceeded the first-to-market phosphodiesterase 5 (PDE5) inhibitor Revatio (sildenafil; Pfizer), generic competition in the US from 2018 will significantly erode Adcirca's sales. Conversely, continued uptake of PDE5 inhibitors in combination with endothelin receptor antagon.(ERAs) based on the AMBITION trial will act as an opposing force, offsetting some of the losses.

Key Topics Covered:

OVERVIEW

  • Drug Overview
  • Product Profiles
  • Adcirca: Pulmonary hypertension

LIST OF FIGURES

  • Adcirca for pulmonary hypertension - SWOT analysis
  • The authors drug assessment summary of Adcirca for pulmonary hypertension
  • Adcirca sales for pulmonary hypertension across the US, Japan, and five major EU markets, by country, 2016-25

LIST OF TABLES

  • Adcirca drug profile
  • Adcirca pivotal trial data in pulmonary hypertension
  • Adcirca sales for pulmonary hypertension across the US, Japan, and five major EU markets, by country ($m), 2016-25

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Related Topics: Respiratory Drugs

Contacts

ResearchAndMarkets.com
Laura Wood, Senior Press Manager
press@researchandmarkets.com
For E.S.T Office Hours Call 1-917-300-0470
For U.S./CAN Toll Free Call 1-800-526-8630
For GMT Office Hours Call +353-1-416-8900
Related Topics: Respiratory Drugs