Jardiance (empagliflozin; Boehringer Ingelheim/Eli Lilly) Overview and Profile 2019 - ResearchAndMarkets.com

DUBLIN--()--The "Jardiance" drug pipelines has been added to ResearchAndMarkets.com's offering.

Jardiance (empagliflozin; Boehringer Ingelheim/Eli Lilly) is a sodium-glucose cotransporter-2 (SGLT-2) inhibitor originally developed by Boehringer Ingelheim for the treatment of type 2 diabetes. As part of the companies' strategic diabetes alliance, Jardiance's late-stage development and commercialization was conducted with Eli Lilly.

The drug is jointly marketed by both companies. In August 2014, Eli Lilly and Boehringer Ingelheim received regulatory approval from the US Food and Drug Administration, having previously been issued a complete response letter in March 2014. The drug was initially rejected due to previously identified failings at a Boehringer Ingelheim manufacturing facility.

The European Commission approved the drug in May 2014.

Jardiance exerts its pharmacological effect by inhibiting SGLT-2, which is expressed almost exclusively in the kidney. Located in the proximal tubule, the SGLT-2 transport system is involved in the reabsorption of glucose. As such, inhibition of the transport protein prevents glucose reabsorption, resulting in excretion through the urine. The drug has also demonstrated improvements in cardiovascular (CV) outcomes in type 2 diabetes patients at high risk of, or with a history of, adverse CV events.

Plans have also been announced for a Phase III trial of Jardiance for the treatment of chronic kidney disease, including diabetic nephropathy.

Key Topics Covered:

OVERVIEW

Drug Overview

Product Profiles

Jardiance : Diabetic nephropathy

Jardiance : Chronic heart failure (CHF)

Jardiance : Diabetes type 2

Companies Mentioned

  • Boehringer Ingelheim
  • Eli Lilly

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Contacts

ResearchAndMarkets.com
Laura Wood, Senior Press Manager
press@researchandmarkets.com
For E.S.T Office Hours Call 1-917-300-0470
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Related Topics: Endocrine and Metabolic Disorders Drugs, Diabetes Drugs

Contacts

ResearchAndMarkets.com
Laura Wood, Senior Press Manager
press@researchandmarkets.com
For E.S.T Office Hours Call 1-917-300-0470
For U.S./CAN Toll Free Call 1-800-526-8630
For GMT Office Hours Call +353-1-416-8900
Related Topics: Endocrine and Metabolic Disorders Drugs, Diabetes Drugs