CAMBRIDGE, Mass. & SALISBURY, England--(BUSINESS WIRE)--KalVista Pharmaceuticals, Inc. (NASDAQ:KALV), a clinical stage pharmaceutical company focused on the discovery, development, and commercialization of small molecule protease inhibitors, announced that data has been accepted for presentation at both the C1 Inhibitor Deficiency and Angioedema Workshop in Budapest, Hungary and European Academy of Allergy and Clinical Immunology (EAACI) Congress in Lisbon, Portugal.
“We are excited to present more Phase 1 data on KVD900, our oral plasma kallikrein inhibitor in development for on-demand treatment of hereditary angioedema, or HAE,” said Andrew Crockett, Chief Executive Officer of KalVista. “Our Phase 2 clinical trial of KVD900 is still expected to have data late this year. We remain committed to providing options for patients to manage their disease with oral medicines.”
C1 Inhibitor Workshop Presentations:
KVD900, a new oral on-demand treatment of hereditary angioedema
attacks achieves complete plasma kallikrein suppression: safety,
tolerability, pharmacokinetic and pharmacodynamic results from a phase
1 first-in-human study
Saturday, May 25, 2019 from 11:00-12:30 CEST, Oral 25
High plasma exposures of KVD900 achieved in First in Human study
markedly inhibit plasma prekallikrein activation; early blockade of
plasma kallikrein (PKa) may halt attacks in hereditary angioedema
(HAE) by reducing contact system activation
Saturday, May 25, 2019 from 2:30-4:00 pm CEST, Poster 35
Rapid and Nearly Complete Suppression of Plasma Kallikrein Activity
with the Oral Inhibitor KVD900: Results of a Phase 1 Study Evaluating
KVD900’s Potential as a Treatment for Acute Attacks of HAE
Tuesday, June 4, 2019 from 10:30-12:00 pm WEST
PDS #21, Mediators in anaphylaxis and angioedema, Zone B
About KalVista Pharmaceuticals, Inc.
KalVista Pharmaceuticals, Inc. is a pharmaceutical company focused on the discovery, development, and commercialization of small molecule protease inhibitors for diseases with significant unmet need. The initial focus is on inhibitors of plasma kallikrein, which is an important component of the body’s inflammatory response and which, in excess, can lead to increased vascular permeability, edema and inflammation. KalVista has developed a proprietary portfolio of novel, small molecule plasma kallikrein inhibitors initially targeting hereditary angioedema (HAE) and diabetic macular edema (DME). The Company has created a structurally diverse portfolio of oral plasma kallikrein inhibitors and is advancing multiple drug candidates for HAE as well as DME. The Company has selected KVD900 as its program to be advanced as an on-demand therapy for HAE attacks and commenced a Phase 2 proof-of-concept study in HAE patients in late 2018. In DME, KalVista’s most advanced program, an intravitreally administered plasma kallikrein inhibitor known as KVD001, began a Phase 2 clinical trial in 2017 that is anticipated to complete in the second half of 2019.
For more information, please visit www.kalvista.com.
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