SKOKIE, Ill.--(BUSINESS WIRE)--Exicure, Inc. (OTCQB:XCUR), the pioneer in gene regulatory and immunotherapeutic drugs utilizing three-dimensional, spherical nucleic acid (SNA™) constructs, announced today that it has presented pre-clinical data in a poster session at the 14th Annual Meeting of the Oligonucleotide Therapeutics Society (OTS) in Seattle, Washington from September 30-October 3, 2018.
“On behalf of the Exicure team, we are pleased to present the first data highlighting oral delivery of our spherical nucleic acid technology,” said Dr. David Giljohann, Chief Executive Officer of Exicure. “We are also sharing for the first time our work conducted with Regulus Therapeutics Inc. (NASDAQ: RGLS) showing that Exicure’s platform improves functional delivery of nucleic acids to the liver. Both studies underscore the importance of the Exicure technology for gene regulatory applications and open up new avenues for application of spherical nucleic acids.”
The first poster, authored and presented by Exicure scientists, titled “Spherical Nucleic Acids: Oral delivery and efficacy in TNBS-induced IBD model,” supports the local delivery benefits of Exicure’s proprietary platform technology. The imaging data presented in the poster show bio-distribution of SNAs following oral delivery in the GI tract of mice, including tissue penetration and cellular internalization. In addition, in a mouse model of inflammatory bowel disease, oral administration of SNAs showed improved clinical symptoms, colon gross pathology, body weight, and survival.
A second poster showcases data generated by Regulus Therapeutics through an ongoing scientific collaboration with Exicure. The poster, titled “Spherical Nucleic Acid (SNA) construct improves functional delivery of anti-microRNA oligonucleotide in pre-clinical studies in vitro and in vivo,” highlights improved delivery to the liver following systemic administration in mice and indicates the potential to broaden the application of Exicure’s proprietary SNA™ technology to miRNA targeting.
About Exicure, Inc.
Exicure, Inc. is a clinical stage biotechnology company developing a new class of immunomodulatory and gene regulating drugs against validated targets. Exicure's proprietary 3-dimensional, spherical nucleic acid spherical nucleic acid (SNA™) architecture is designed to unlock the potential of therapeutic oligonucleotides in a wide range of cells and tissues. Exicure's lead programs address inflammatory diseases, genetic disorders and oncology. Exicure is based outside of Chicago, IL. www.exicuretx.com.
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