GeNeuro Presents New Data Highlighting Role of Human Endogenous Retroviruses in Type 1 Diabetes at American Diabetes Association’s (ADA) 78th Scientific Sessions

  • Preclinical models confirm involvement of pHERV-W-Env in human Type 1 diabetes (T1D) pathogenesis
  • 6-months results from Phase IIa trial with GNbAC1 in T1D expected by end of September 2018

GENEVA--()--Regulatory News:

GeNeuro (Paris:GNRO) (Euronext Paris: CH0308403085 - GNRO), a biopharmaceutical company developing new treatments for neurological and autoimmune diseases, including multiple sclerosis (MS) and type 1 diabetes (T1D), today announced that new data from mouse models confirm the involvement of a pathogenic protein encoded by a member of the human endogenous retroviruses (HERV-W) family, pHERV-W Env, in human T1D pathogenesis. Data were presented at the American Diabetes Association 78th Scientific Session, being held June 22-26, 2018 in Orlando, Florida.

In this preclinical study, normal and transgenic mice in which pHERV-W Env is expressed were given streptozotocine, a toxic molecule known to induce experimental diabetes. Following streptozotocine exposure, transgenic mice were found to be more susceptible to pancreatic damage than wild-type mice as they developed more severe insulitis (P < 0.0001) and hyperglycemia (P < 0.01). Moreover, pHERV-W Env transgenic mice displayed severe pancreatic abnormalities that could explain their susceptibility to streptozotocine. The researchers concluded that if these transgenic mice results can be translated into humans, they could support a role for pHERV-W Env in T1D pathogenesis, particularly in patients expressing this pathogenic protein. The poster outlining these results is available on the GeNeuro website.

GeNeuro is conducting a 60-patient Phase IIa in T1D, called RAINBOW, with its lead product, GNbAC1. Initial 6-months results are expected to be announced by end of September 2018.

GNbAC1 is a monoclonal antibody designed to neutralize a pHERV-W Env. In a large-scale Phase IIb clinical trial in 270 MS patients, GNbAC1 has already successfully demonstrated a major impact on three key neuroprotection markers known to be linked to disease progression, without affecting the patients’ immune system.

About Type 1 Diabetes

Type 1 diabetes, usually first diagnosed in children, is caused by an immune response directed against the insulin producing cells of the pancreas. There is no cure for this ‘autoimmune’ disease, which means patients need life-long treatment with insulin replacement. This treatment is often associated with several debilitating complications, including heart disease, blindness, and kidney disease, among others.

About GeNeuro

GeNeuro‘s mission is to develop safe and effective treatments against neurological disorders and autoimmune diseases, such as multiple sclerosis, by neutralizing causal factors encoded by HERVs, which represent 8% of human DNA.

GeNeuro is based in Geneva, Switzerland and has R&D facilities in Lyon, France. It has 29 employees and rights to 16 patent families protecting its technology.

For more information, visit: www.geneuro.com

Disclaimer

This press release contains certain forward - looking statements and estimates concerning GeNeuro’s financial condition, operating results, strategy, projects and future performance and the markets in which it operates. Such forward-looking statements and estimates may be identified by words, such as “anticipate,” “believe,” “can,” “could,” “estimate,” “expect,” “intend,” “is designed to,” “may,” “might,” “plan,” “potential,” “predict,” “objective,” “should,” or the negative of these and similar expressions. They incorporate all topics that are not historical facts. Forward looking statements, forecasts and estimates are based on management’s current assumptions and assessment of risks, uncertainties and other factors, known and unknown, which were deemed to be reasonable at the time they were made but which may turn out to be incorrect. Events and outcomes are difficult to predict and depend on factors beyond the company’s control. Consequently, the actual results, financial condition, performances and/or achievements of GeNeuro or of the industry may turn out to differ materially from the future results, performances or achievements expressed or implied by these statements, forecasts and estimates. Owing to these uncertainties, no representation is made as to the correctness or fairness of these forward-looking statements, forecasts and estimates. Furthermore, forward-looking statements, forecasts and estimates speak only as of the date on which they are made, and GeNeuro undertakes no obligation to update or revise any of them, whether as a result of new information, future events or otherwise, except as required by law.

Contacts

GeNeuro
Jesús Martin-Garcia
Chairman and CEO
+41 22 552 4800
investors@geneuro.com
or
NewCap (France)
Julien Perez (investors)
+33 1 44 71 98 52
or
Nicolas Merigeau (media)
+33 1 44 71 94 98
geneuro@newcap.eu
or
Halsin Partners
Mike Sinclair (media)
+44 20 7318 2955
msinclair@halsin.com
or
LifeSci Advisors

Chris Maggos (investors)
+1 646 597 6970
+41 79 367 6254
chris@lifesciadvisors.com

Contacts

GeNeuro
Jesús Martin-Garcia
Chairman and CEO
+41 22 552 4800
investors@geneuro.com
or
NewCap (France)
Julien Perez (investors)
+33 1 44 71 98 52
or
Nicolas Merigeau (media)
+33 1 44 71 94 98
geneuro@newcap.eu
or
Halsin Partners
Mike Sinclair (media)
+44 20 7318 2955
msinclair@halsin.com
or
LifeSci Advisors

Chris Maggos (investors)
+1 646 597 6970
+41 79 367 6254
chris@lifesciadvisors.com