Evenity (romosozumab; Amgen/UCB/Astellas) Drug Overview Report 2018 - ResearchAndMarkets.com

DUBLIN--()--The "Drug Overview: Evenity" report has been added to ResearchAndMarkets.com's offering.

Evenity (romosozumab; Amgen/UCB/Astellas) is a novel humanized monoclonal antibody therapy targeting the osteocyte-produced protein sclerostin, which inhibits bone formation in osteoblastic cells. As such, Evenity has an anabolic effect, and is being developed as a treatment for postmenopausal women with osteoporosis. Sclerostin is a key part of the negative feedback loop that acts to control the activity of osteoblastic cells. Knockout mice for SOST, the gene encoding sclerostin, show an increase in bone formation, resulting in greater bone mass and strength.

It is hypothesized that by inhibiting the activity of sclerostin as opposed to the activity of osteoclasts or osteoblasts directly, Evenity acts to uncouple the bone formation and bone resorption processes. This prevents the rebound increase in osteoclastic bone resorption that can be seen when parathyroid or parathyroid hormone-related peptides are used. This has been illustrated in both animal and human studies.

Key Topics Covered:

OVERVIEW

Drug Overview

Product Profiles

Evenity: Osteoporosis

List of Figures

Figure 1: Evenity for osteoporosis - SWOT analysis

Figure 2: Drug assessment summary of Evenity for osteoporosis

Figure 3: Drug assessment summary of Evenity for osteoporosis

List of Tables

Table 1: Evenity drug profile

Table 2: Evenity pivotal trial data in osteoporosis

Table 3: Evenity other late-phase trials in osteoporosis

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Related Topics: Endocrine and Metabolic Disorders Drugs, Musculoskeletal Disorders Drugs

Contacts

ResearchAndMarkets.com
Laura Wood, Senior Manager
press@researchandmarkets.com
For E.S.T Office Hours Call 1-917-300-0470
For U.S./CAN Toll Free Call 1-800-526-8630
For GMT Office Hours Call +353-1-416-8900
Related Topics: Endocrine and Metabolic Disorders Drugs, Musculoskeletal Disorders Drugs