Natrecor (Nesiritide; Johnson & Johnson) Drug Outlook to 2025 - ResearchAndMarkets.com

DUBLIN--()--The "Drug Overview: Natrecor" report has been added to ResearchAndMarkets.com's offering.

Natrecor (nesiritide; Johnson & Johnson) is a recombinant form of human brain natriuretic peptide (BNP), a circulating hormone of cardiac origin indicated for the treatment of patients with acute decompensated heartf failure (ADHF) who have dyspnea at rest or with minimal activity. BNP is naturally secreted by the ventricular myocardium in response to volume overload and increased filling pressure.

It binds to the particulate guanylate cyclase receptor of vascular smooth muscle and endothelial cells, leading to increased intracellular concentrations of guanosine 3'5'-cyclic monophosphate (cGMP) and smooth muscle cell relaxation. cGMP serves as a second messenger to dilate veins and arteries, and Natrecor causes natriuresis and a reduction in intravascular volume. The natriuretic effect results from a direct inhibition of sodium absorption in the renal collecting duct, increased glomerular infiltration, and inhibited aldosterone production and secretion. This produces a prompt fall in systemic vascular resistance and pulmonary capillary wedge pressure, associated with rapid clinical improvement in ADHF.

Key Topics Covered

  1. Product Profiles
  2. Natrecor: Acute Decompensated Heart Failure (ADHF)

List of Figures

Figure 1: Natrecor for ADHF - SWOT analysis

Figure 2: Drug assessment summary for Natrecor in ADHF

Figure 3: Drug assessment summary for Natrecor in ADHF

List of Tables

Table 1: Natrecor drug profile

Table 2: Natrecor Phase III data in ADHF

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Related Topics: Cardiovascular Drugs

Contacts

ResearchAndMarkets.com
Laura Wood, Senior Manager
press@researchandmarkets.com
For E.S.T Office Hours Call 1-917-300-0470
For U.S./CAN Toll Free Call 1-800-526-8630
For GMT Office Hours Call +353-1-416-8900
Related Topics: Cardiovascular Drugs