BMS-986231 (Bristol-Myers Squibb/Ligand) Drug Analysis 2018 - ResearchAndMarkets.com

DUBLIN--()--The "Drug Analysis: BMS-986231" drug pipelines has been added to ResearchAndMarkets.com's offering.

BMS-986231 (Bristol-Myers Squibb/Ligand) is a second-generation prodrug that chemically breaks down to produce nitroxyl (HNO) and an inactive byproduct. HNO is thought to have a dual mode of action, by improving cardiac function and acting as a vasodilator. Additionally, HNO is thought to enhance myocardial function by improving calcium cycling and also myofilament calcium sensitivity. Finally, HNO acts a vasodilator through activation of soluble guanylate cyclase and activation of potassium channels in vascular smooth muscle.

BMS-986231's proposed dual mode of action and good tolerability could be presented as an improvement over currently used phosphodiesterase III inhibitors and Simdax (levosimendan; Orion/Tenax Therapeutics). However, more clinical data are required in order to verify the mechanism and identify any possible safety issues. The potential to act as an inotropic agent and a potent vasodilator could result in significant uptake in a highly genericized acute decompensated heart failure market, but until more is known regarding safety, no clear conclusions can be made regarding this product.

Key Topics Covered:

1 Product Profiles

  • BMS-986231: Acute decompensated heart failure (ADHF)

List of Figures

Figure 1: BMS-986231 for ADHF - SWOT analysis

Figure 2: The author's drug assessment summary of BMS-986231 for ADHF

Figure 3: The author's drug assessment summary of BMS-986231 for ADHF

List of Tables

Table 1: BMS-986231 drug profile

Table 2: BMS-986231 Phase II data in ADHF

Table 3: BMS-986231 Phase II trials in ADHF

For more information about this drug pipelines report visit https://www.researchandmarkets.com/research/z9wbx5/bms986231?w=4

Contacts

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Related Topics: Cardiovascular Drugs

Contacts

ResearchAndMarkets.com
Laura Wood, Senior Manager
press@researchandmarkets.com
For E.S.T Office Hours Call 1-917-300-0470
For U.S./CAN Toll Free Call 1-800-526-8630
For GMT Office Hours Call +353-1-416-8900
Related Topics: Cardiovascular Drugs