The research study covers the present scenario and growth prospects of the global organ transplant immunosuppressant market for 2017-2021. The market is segmented based on drug class and therapeutic application (kidney, liver, heart, lung, pancreas, and other transplants) and geography (the Americas, EMEA, and APAC).
The organ transplant immunosuppressant market is likely to grow at a steady pace during the forecast period. The sales of immunosuppressant will increase due to the rising incidence of chronic diseases such as chronic kidney disease, end-stage renal disease, coronary artery disease, and acute and chronic hepatitis among all age groups, particularly the geriatric population. Though there are advanced treatments for chronic kidney disease and chronic hepatitis infection, the individual's health can deteriorate with time, which can increase the need for kidney and liver transplantation.
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Technavio healthcare and life sciences research analysts highlight the following three factors that are contributing to the growth of the global organ transplant immunosuppressant market:
- Increased incidence of organ failure
- Complications associated with organ transplantation
- Availability of efficacious immunosuppressant
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Increased incidence of organ failure
Globally, there is a high demand for tissues and organs such as bone marrow, heart, liver, kidney, and lungs. The increased alcohol consumption, unhealthy lifestyles and food habits, and drug intake are the leading causes of organ failure. In addition, the rise in aging population results in increased demand for organs for transplantation.
Sapna Jha, a lead cardiovascular and metabolic disorders research analyst at Technavio, says, “As of 2014, multiple studies in countries such as Canada showed that the prevalence of non-alcoholic fatty liver disease has increased. People surviving with NAFLD can suffer from non-alcoholic steatohepatitis, which causes liver inflammation and damage by building up fat.”
Complications associated with organ transplantation
Seeing the advancement in surgical techniques and ancillary care over the past few years, graft rejection is the primary limitation for the solid organ transplantation. Transplant rejection is a response of the recipient's immune system. The transplanted organ or tissue is recognized as a foreign body and triggers a blood transfusion reaction, which leads to transplant rejection.
“Transplant rejection is one of the major causes of transplant failure. Therefore, to achieve successful organ transplant, immunosuppressive therapy may be required. The first randomized clinical trial began in Europe and Canada in 1981 for cyclosporine, which is now considered as one of the best immunosuppressant available in the market,” adds Sapna.
Availability of efficacious immunosuppressant
In the past few decades, the research on new, experimental immunosuppressive drugs with novel MoA has gathered significant momentum. Many new products have reached the market. The main reason behind the tremendous proliferation of newer immunosuppressant is the growing understanding of the immune mechanism, which leads to organ rejection or transplant failure, particularly reactions that leads to T-cell activation.
As the understanding of immune responses increases, drugs can be targeted more effectively, resulting in both decreased organ rejection and toxicity. This has also led to customization of immunosuppressive drugs according to individual patient and tailor the treatment according to individual's need.
- Astellas Pharma
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