MILAN--(BUSINESS WIRE)--Newron Pharmaceuticals S.p.A. (“Newron”), a biopharmaceutical company focused on the development of novel therapies for patients with diseases of the central nervous system (CNS) and pain, today announces that Ravi Anand, M.D., Newron’s Chief Medical Officer, will make an oral presentation entitled “Evenamide, a Putative Antipsychotic, Targets Abnormal Electrical Activity and Glutamatergic Abnormalities to Improve Psychotic Symptoms in Patients With Schizophrenia: Results From a Phase II, Placebo-Controlled Trial” at the 16th International Congress on Schizophrenia Research, ICOSR, taking place on March 24-28, 2017 at the Manchester Grand Hyatt in San Diego, California, USA.
The abstract will be presented on Saturday, March 25, 3:45-4:00 pm PT, as part of the “Clinical Trials” oral session in Seaport Ballroom F.
Evenamide (NW-3509) is a new generation antipsychotic that acts through pathways not targeted by current treatments or other putative antipsychotics. It is associated with a functional blockade of voltage-gated sodium channels that inhibits glutamate release by reducing the firing rate of hyper-excited neurons and may normalize aberrant cortical and hippocampal activity.
The double-blind, 28-day, placebo-controlled, Phase 2 study evaluated safety, tolerability, and preliminary evidence of efficacy of Evenamide as an add-on to a stable dose of risperidone or aripiprazole in 89 schizophrenia outpatients. Patients received placebo or Evenamide (15-25mg bid). The dose escalation from 15 to 20 to 25 mg bid was done weekly in an inpatient setting, based on tolerability. The study concludes that the combination of Evenamide as an add-on to marketed antipsychotics in patients showing return of symptoms would combine reduction of aberrant electrical activity and normalization of glutamate release with blockade of 5HT2/D2 receptors, thus producing a novel therapeutic option.
About Newron Pharmaceuticals
Newron (SIX: NWRN) is a biopharmaceutical company focused on the development of novel therapies for patients with diseases of the central nervous system (CNS) and pain. The Company is headquartered in Bresso near Milan, Italy, with a subsidiary in Morristown, NJ, USA. Xadago® (safinamide) has received marketing authorization for the treatment of Parkinson’s disease in the European Union and Switzerland and is commercialized by Newron’s partner Zambon. US WorldMeds holds the commercialization rights in the USA. Meiji Seika has the rights to develop and commercialize the compound in Japan and other key Asian territories. In addition to Xadago® for Parkinson’s disease, Newron has a strong pipeline of promising treatments for rare disease patients at various stages of clinical development, including sarizotan for patients with Rett syndrome and ralfinamide for patients with specific rare pain indications. Newron is also developing Evenamide as the potential first add-on therapy for the treatment of patients with positive symptoms of schizophrenia. www.newron.com.
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