ST. LOUIS--(BUSINESS WIRE)--Euclises Pharmaceuticals, Inc., a privately held drug discovery and development company focused on novel third-generation cyclooxygenase-2 (COX-2) inhibitors for use in the treatment of cancer, today announced that Bobby W. Sandage, Jr., Ph.D., president and chief executive officer, will present an overview of the company and its programs at the 9th Annual Biotech Showcase Conference on Monday, January 9, 2017 at 9:45 a.m. PST. The conference will take place at the Hilton San Francisco Union Square, San Francisco, CA.
Euclises Pharmaceuticals, Inc., is a drug discovery and development company focused on novel third-generation cyclooxygenase-2 (COX-2) inhibitors for use in the treatment of cancer. These drugs are designed to work in combination with certain other anti-cancer drugs, in particular checkpoint inhibitors (CIs), by preventing COX-2 produced PGE-2 from inhibiting the natural immune cells from killing cancer cells.
COX-2 produced PGE-2 inhibits cytotoxic T-cell function in the tumor microenvironment. Euclises’ lead candidate inhibits COX-2, blocks PGE-2 production and thereby synergizes with CIs, which depend on the activity of the patient’s own immune system to work at peak performance. In preclinical studies, Euclises’ drug candidate has demonstrated the ability to enhance the efficacy of CIs in boosting immune control of tumors. In addition, in a number of tumor types, PGE-2 drives cancer cell proliferation, and Euclises’ lead candidate has been shown non-clinically to be effective in inhibiting tumor growth alone and in combination with other targeted therapies.
Euclises has selected a clinical development candidate and is currently conducting studies in preparation for human clinical trials with the goal of submitting an Investigational New Drug (IND) application to the FDA in the first half of 2017. For more information, visit the Euclises website at www.euclises.com.
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