Examine the World Biotechnology Reagents Market

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World Biotechnology Reagents Market

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This report analyzes the worldwide markets for Biotechnology Reagents in Millions of US$. The specific product segments analyzed are Cell/Tissue Culture Reagents, DNA Sequencing/Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents. The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, and Latin America. Annual forecasts are provided for each region for the period of 2000 through 2015. The report profiles 269 companies including many key and niche players worldwide such as Abbott Diagnostics, Applied Biosystems, Beckman Coulter, Inc., Becton Dickinson and Company, Biomerieux SA, Chemicon International, Inc., EMD Biosciences, Inc., Fitzgerald Industries International, GE Healthcare, Invitrogen Corporation, Ortho-Clinical Diagnostics, Perkin Elmer, Inc., Promega Corp., Roche Diagnostics Ltd., Siemens Healthcare Diagnostics, Inc., and Sigma – Aldrich. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources.

BIOTECHNOLOGY REAGENTS MCP-3533 A GLOBAL STRATEGIC BUSINESS REPORT

CONTENTS

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

Study Reliability and Reporting Limitations I-1 Disclaimers I-2 Data Interpretation & Reporting Level I-2 Quantitative Techniques & Analytics I-3 Product Definitions and Scope of Study I-3 Cell & Tissue Culture Reagents I-3 DNA Synthesis & Sequencing Reagents I-4 Electrophoresis Reagents I-4 Flow Cytometry Reagents I-4 Immunoassay Reagents I-4 Liquid Chromatography Reagents I-5 PCR Reagents I-5 Protein Synthesis & Sequencing Reagents I-5

II. EXECUTIVE SUMMARY

1. Outlook II-1 Reagents Market Players Witnessing Paradigm Shift II-1

2. Market Dynamics II-2 Highly Automated Instrumentation Restricts Use of Reagents II-2 Software-Intensive Nature and High System Complexity Impedes Use of Automated Instruments II-2 Demand for Diverse Products Spurs Growth II-2 Increasing Use in Industrial Sector II-2 Molecular Biology and Protein Synthesis Reagents - the Fastest Growing Segments II-3 Obtaining Data from Enzyme Functions II-3 New Economy Sees the Entry of Directed Evolution Enzymes II-3

3. Biotechnology - Industry Overview II-4 Growing by Leaps and Bounds II-4 Human Genome Mapping - A Colossal Milestone II-4 High Growth Applications Spur Industry Growth II-5 Biochips- Promising Future II-5 Convergence of Distinct Technologies II-6 Growing Collaboration between Biotech and Pharma Companies II-6

4. Product Overview II-7 A. Classification II-7 i. DNA Synthesis & Sequencing Reagents II-7 DNA: The Basis for Modern Biotechnology II-7 ii. PCR Reagents II-7 iii. Protein Synthesis & Sequencing Reagents II-7 iv. Electrophoresis Reagents II-8 v. Bio/Chemiluminescence Reagents II-8 vi. Immunoassay Reagents II-8 Antibodies II-8 Monoclonal and Polyclonal Antibodies II-8 Types of Monoclonal Antibodies II-8 a. Murine Monoclonal Antibodies II-8 b. Human Antibodies II-9 c. Chimeric Antibodies II-9 d. Bispecific Antibodies II-9 Hematology/Coagulation Reagents II-9 vii. Chromatography Reagents II-9 viii. Flow Cytometry Reagents II-9 ix. Cell & Tissue Culture Reagents II-10

5. Product Innovations/Introductions II-11 Beckman Coulter Introduces Two IOTest® Reagents II-11 Applied Biosystems Announces New Reagents II-11 Calypte Biomedical Introduces New Calypte Life Sciences Family of Products II-12 Applied Biosystems Launches TaqMan® Cells-to-CT™ Kit Solutions II-12 Applied Biosystems Launches iTRAQ® Reagents II-12 PerkinElmer Launches Series 275 HRes™ LC System II-13 Sigma-Aldrich Introduces Imprint™ ChIP Kit II-13 Stratagene Introduces Expanded QPCR, QRT-PCR Reagents Line II-13 Asuragen Introduces Signature® LTx in Markets Worldwide II-13 Biomatrica Launches PCRboost™ - A New Reagent II-14 Genetix Group Launches New CytoGenetix FISH Kits and Reagents II-14 Strategic Diagnostics Introduces New Online Catalog of Antibody Reagents II-15 Bioatlas Expands Bioatlas Product Lineup with Atlas Antifade II-15 ScienceXperts & Invitrogen Develop Flow Cytometry Software II-15 Beckman Coulter Launches Cell Signal Transduction Reagents II-15 Sigma-Aldrich Launches LentiExpress™ Technology II-16 Abbott Unveils New Assays and Reagents II-16 Applied Biosystems Introduces New Master Mix Reagent II-16 Promega Designs Advanced Luciferase Assay II-16 Ortho-Clinical Diagnostics Expands Test-Base for Infectious Diseases II-17 Genetix Launches Two Novel ''CloneMedia'' Semi-Solid Media Products II-17 Invitrogen Launches Lipofectamine LTX II-17 Beckman Coulter Launches IOTest® Anti-Rat Flow Cytometry Reagents II-17 EMD Biosciences Introduces ProteoPlex® Human Angiogenesis Array II-18 AspenBio Pharma Launches New Single-Chain Gonadotropin II-18 Ortho-Clinical Diagnostics Launches VITROS® Chemistry Products d%A1c Reagent II-18 Beckman Coulter to Launch Access DHEA-S II-18 Solulink Introduces ChromaLink II-18 Cambrex Launches Versalinx Reagents II-19 Kreatech Unveils a New Range of Isolation and Labeling Kits II-19 Nanogen Launches Enterovirus Analyte Specific Reagent - MGB Alert™ II-19 Olympus Unveils New Reagent Kit with Single Molecular Fluorescence Spectroscopy II-19 SAFC Releases Proligo Reagents II-19 LI-COR Biosciences Releases New IRDye® Western Kits for Odyssey® System II-19 Altor Launches STAR™ Multimer Reagents II-19 Guava Technologies Launches a New Range of Antibody Reagents II-20 Solexa Launches Genome Analysis System II-20 Daiichi Unveils New Reagent Kit II-20 Beckman Coulter Introduces Cellular Research Reagents II-20 ReaMetrix Introduces Accuford II-20 TriPath Imaging Unveils ProEx C II-20 Roche and 454 Life Sciences Launches Genome Sequencer 20 System and Reagents II-21 Chinese Academy of Military Medical Sciences Introduces Reagent to Test Drug Resistance of HBV II-21 SIAL Unveils SYBR Green Extract-N-Amp Tissue PCR Kit II-21 Aldrich Introduces LAB Reagents II-21 Kreatech Rolls Out RNA ampULSe Amplification and Labeling Kits II-21 bioMérieux Launches NucliSens miniMAG and NucliSens Magnetic Extraction Reagents II-21 Guava Technologies Launches a New Cell Cycle Assay II-21 U.S. Genomics Introduces Direct miRNA Reagents for Trilogy Platform II-22 Dharmacon Inc, Introduces siGENOME(TM) siRNA II-22 Agencourt Bioscience Introduces RNA Isolation and Purification Kit II-23 Caliper Life Sciences in Collaboration with Promega Offers Automation Protocols II-23 French Researchers Develop Novel Sandwich Immunoassay for Small Molecule Study II-23 Do-Coop Technologies Launches Water-based Nano-Reagent II-24 Affymetrix Inc, Collaborates with Invitrogen to Launch Reagents for GeneChip II-24 Roche Unveils Amplicor HPV in the US II-24 Shimadzu Develops Reagent for Cell-Free Protein Synthesis II-24 Roche Working on PCR-based Linear Array Test for HPV II-25

6. Recent Industry Activity II-26 Invitrogen Plans to Acquire Applied Biosystems II-26 FASgen and Tetracore Ink Collaboration Agreement II-26 Prodesse and Quidel Ink a Co-Commercialization Agreement II-26 Bexion and MTTI to Collaborate for New Nanovesicle II-27 BD Acquires Cytopeia II-27 Affymetrix Acquires USB II-27 Millipore and Guava Technologies Enter into Collaboration II-27 Hologic Agrees to Acquire Third Wave II-28 Spartan Bioscience and TrimGen Enter into Partnership II-28 Multispan & Promega to Co-Develop Assay Tools II-28 STEMCELL Joins Forces with Geron II-29 HistoRx Signs Agreement with Eli Lilly II-29 GE Healthcare to Take Over Whatman II-29 Inverness Takes Over BBI II-30 Medical Solutions to Take Over Autogen II-30 Sysmex and bioMerieux Agree to Establish a Joint Venture II-30 Miltenyi Acquires Medic II-30 China Medical Acquires Beijing Bio-Ekon II-31 Gene Bridges Partners with Mbiotech II-31 Roche Acquires Ventana Medical II-31 BioMérieux to Shutdown Boxtel Facility II-31 Abbott Inks Agreement with Premier II-32 Beckman Coulter Acquires Dako’s Flow Cytometry Instrumentation Business II-32 Cliniqa Acquires the Assets of Reagents Applications II-32 Frontier Scientific Acquires Echelon Biosciences II-32 Immucor Signs Supply Agreement with American Red Cross II-33 Ventana Medical Takes Over Spring BioScience II-33 TriLink Biotechnologies Inks Agreement with Applied Biosystems II-33 Bio-Rad Takes Over DiaMed Holdings II-33 PerkinElmer Takes Over ViaCell II-34 Sigma-Aldrich in Alliance with Sangamo BioSciences II-34 Fitzgerald Industries Takes Over Cortex Biochem’s Immunoreagent Business II-34 Agilent Technologies Acquires Stratagene II-35 Dendritic Signs Supply Agreement with EMD Biosciences II-35 Spectral Diagnostics Inks Agreement with Bio-Rad II-35 Japanese Atol Plans to Acquire a Major Stake in Naha Yakuhin II-35 Roche Takes Over NimbleGen II-35 Roche Takes Over BioVeris II-36 Roche Acquires 454 Life Sciences II-36 Sysmex & Roche Diagnostics Extend Distribution Agreement II-36 Invitrogen and Biocon Inks Exclusive Marketing Agreement II-36 PerkinElmer Acquires Remaining Stake in PerkinElmer India II-37 Promega Enters Into Alliance with Guangzhou Institute II-37 Adaltis Acquires Shanghai Hua Tai Biotechnology II-37 ABR-Affinity Inks Distribution Agreements with Genesis & Good Biotech II-38 The PLSG Makes Financial Investment in AIT II-38 Numira Merges with Visual Influence II-38 Abbott Receives FDA Clearance for CELL-DYN Ruby™ II-38 Tm Bioscience Bags Supply Contract JMC II-39 ReaMetrix Receives Clearance for Accuford Tri-T Stat II-39 Panomics Establishes New Subsidiary in Europe II-39 Promega Completes Benitec Acquisition II-39 NCGC Joins Forces with PerkinElmer II-39 MBL Acquires Antibody Business of LifeSpan BioSciences II-40 Sigma-Aldrich and Genospectra Sign a Series of Agreements II-40 Nitragin Completes the Acquisition of Agribiotics II-40 Fujirebio Diagnostics Acquires CanAg Diagnostics II-40 Chemicon Inks an Agreement with ASCC II-41 Takara Bio. Pharma Acquires Stakes in Takara Biotechnology II-41 Millipore Takes Over Serologicals II-41 Serologicals Takes Over LINCO II-41 Genospectra Merges with Panomics II-41 Roche Enters into Three-Year Contract with Premier II-42 KREATECH and GenTel Enter into Distribution Agreement II-42 Kreatech Enters into Supply Agreement with QIAGEN II-42 Invitrogen to Provide Reagents for Genome Sequencing of Solexa II-42 VWR International to Market Biocare Equipment and Reagents in IHC II-42 Biocare Partners with Epitomics for Reagents II-42 GE and CytoGenix Form an Alliance II-43 Fisher Biosciences Joins Forces with Dyomics II-43 PerkinElmer Partners with NCGC II-43 SAFC-Biosciences Formed to Support Sigma-Aldrich II-43 Takara Bio Takes Over Clonetech II-43 Techne's Subsidiary Pockets BiosPacific and Fortron Bio Science II-44 QIAGEN Obtains Nextal II-44 Invitrogen Takes Over Caltag II-44 Invitrogen Takes Over Biosource International II-44 Serologicals Acquires Specialty Media from Sentigen II-44 Invitrogen Acquires Zymed Laboratories II-44 Biotage Acquires Argonaut Technologies II-44 Invitrogen Acquires Dynal Biotech II-45 Vita and Cortex Biochem Enter into Distribution Agreement II-45 SIAL and OXB Sign an Agreement for Commercializing LentiVector Technology II-45 Funakoshi and Affibody Sign a Distribution Agreement II-45 KREATECH and GenTel Enter into Marketing Agreement II-45 KREATECH and Ambion Enter into Supply Agreement II-45 SIAL Enters into Distribution Agreement with MedAssets II-46 IBT Signs Distribution Contracts for Enzymes II-46 Epitome Signs a License Agreement with EMD Biosciences II-46 Consorta Inks Multiple Agreements with Dade Behring II-46 SCS and Chemicon Sign an Agreement for ES Cell Media II-46 LSBC and BioCatalytics Enter into Collaborative Agreement for Producing Enzymes II-47 Chemicon International Enters into an Agreement with QDC II-47 Dharmacon Signs an Agreement with Genentech II-47 Invitrogen Partners with PerkinElmer II-47 Chemicon and Axordia Collaborate for New Antibody Markers II-47 eGene Enters into Strategic Alliance with Transgenomic II-47 Cancer Genetics Selects Genetics Specialities II-48 Clinical Data Bags Distribution Rights for Hematology Analyzers and Reagents II-48 BD Biosciences to Expand Production in Puerto Rico II-48 Olympus Enlarges R&D Unit in Ireland II-48 Olympus Begins Production of Immunoassay Reagents II-48 Koon-wah Leong, Shery Guo and Suyue Qian Produces Multilayer Test Strips II-48 CMT Sells off Specialty Media Division II-49 CSL Divests Cell Culture Reagent Business to Sigma-Aldrich II-49 BD Divests Clontech Business II-49 Hycor Biomedical Merges with Stratagene Corporation II-49 GE Acquires Amersham plc II-49 CalbaTech Snaps Up K-D Medical II-49 Tepnel Life Sciences Acquires Diaclone Research SAS II-50 BD Acquires Atto Bioscience II-50 Invitrogen to Acquire Bio Asia II-50 Idexx Announce Plans to Acquire Switzerland-based Bommeli II-50 Chemicon Announce Plans to Acquire Product Lines from Primogenix II-51 Bio-Rad Laboratories to Acquire MJ GeneWorks II-51 D. Lansing Taylor Join Forces with PLSG to Create Cellumen II-51 eGene Inc. and Prisma Biotech form Distribution Alliance II-51 eGene Alliances with HVD Life Science and HVD Biotech Vertriebs-GmbH II-52 Cell Signaling Technology, Inc. and Zeptosens AG Sign Licensing Agreement for CST reagents II-52 Pierce and Tecan Enter into Drug Discovery Covenant II-52 Syntonix and Dyax Enter into Antibody Discovery Pact II-53 NeoPharm Signs an Agreement with Nippon Genetics II-53 Amersham Signs Distribution Agreement with Guava TechnologiesII-53CST and LI-COR Sign an Agreement II-54 Cell Signaling Technology, Inc. Signs Agreement with ProQinase GmbH II-54 Sigma-Aldrich Signs a Distribution Agreement with Avecia II-54 LSBC and Sigma-Aldrich Enter into Recombinant Aprotinin Agreement II-55 Atugen Signs a Contract Research Agreement with Eisai II-55 CII Enters into Sub-License Agreement with Promega II-55 Dharmacon Signs Agreement with Wyeth Pharmaceuticals II-55 SurModics inks Distribution Agreement with SeraCare Life Sciences II-55 Hydra Biosciences Signs Agreement with Evotec OAI AG II-56 Chemicon International Strikes a Deal with Thromb-X N.V. II-56 Ambion Inks Agreement with Applied Biosystems II-56 Cosmo Bio Establishes New US Subsidiary II-56 Agilent Technologies Inc, Establishes Integrated Biology Solutions Unit II-57 CeMines Completes Expansion Program II-57

7. Focus on Select Players Worldwide II-58 Abbott Diagnostics (USA) II-58 Applied Biosystems (USA) II-58 Beckman Coulter, Inc. (USA) II-58 Becton Dickinson and Company (USA) II-59 BioMérieux SA (France) II-59 Chemicon International, Inc. (USA) II-59 EMD Biosciences, Inc. (USA) II-60 Fitzgerald Industries International (USA) II-60 GE Healthcare (UK) II-60 Invitrogen Corporation (US) II-60 Ortho-Clinical Diagnostics (US) II-61 PerkinElmer, Inc. (US) II-61 Promega Corporation (US) II-61 Roche Diagnostics Ltd. (Switzerland) II-62 Siemens Healthcare Diagnostics, Inc. (USA) II-62 Sigma - Aldrich (USA) II-62

8. Global Market Perspective II-63

Table 1: World Recent Past, Current & Future Market Analysis for Biotechnology Reagents by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-63

Table 2: World Long-term Projections for Biotechnology Reagents by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-64

Table 3: World 10-Year Perspective for Biotechnology Reagents by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-65 World Market for Biotechnology Reagents by Product Segment II-66

Table 4: World Recent Past, Current & Future Market Analysis for Cell / Tissue Culture Reagents by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-66

Table 5: World Long-term Projections for Cell / Tissue Culture Reagents by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-67

Table 6: World 10-Year Perspective for Cell / Tissue Culture Reagents by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-68

Table 7: World Recent Past, Current & Future Market Analysis for DNA Sequencing / Synthesis Reagents by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-69

Table 8: World Long-term Projections for DNA Sequencing / Synthesis Reagents by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-70

Table 9: World 10-Year Perspective for DNA Sequencing / Synthesis Reagents by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-71

Table 10: World Recent Past, Current & Future Market Analysis for Electrophoresis Reagents by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-72

Table 11: World Long-term Projections for Electrophoresis Reagents by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-73

Table 12: World 10-Year Perspective for Electrophoresis Reagents by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-74

Table 13: World Recent Past, Current & Future Market Analysis for Flow Cytometry Reagents by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-75

Table 14: World Long-term Projections for Flow Cytometry Reagents by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-76

Table 15: World 10-Year Perspective for Flow Cytometry Reagents by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-77

Table 16: World Recent Past, Current & Future Market Analysis for Immunoassay Reagents by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-78

Table 17: World Long-term Projections for Immunoassay Reagents by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-79

Table 18: World 10-Year Perspective for Immunoassay Reagents by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-80

Table 19: World Recent Past, Current & Future Market Analysis for Liquid Chromatography Reagents by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-81

Table 20: World Long-term Projections for Liquid Chromatography Reagents by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-82

Table 21: World 10-Year Perspective for Liquid Chromatography Reagents by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-83

Table 22: World Recent Past, Current & Future Market Analysis for Polymerase Chain Reaction Reagents by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-84

Table 23: World Long-term Projections for Polymerase Chain Reaction Reagents by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-85

Table 24: World 10-Year Perspective for Polymerase Chain Reaction Reagents by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-86

Table 25: World Recent Past, Current & Future Market Analysis for Protein Synthesis Reagents by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-87

Table 26: World Long-term Projections for Protein Synthesis Reagents by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-88

Table 27: World 10-Year Perspective for Protein Synthesis Reagents by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-89

III. MARKET

1. United States III-1 A.Market Analysis III-1 Biotech Industry in the US III-1 Escalating Demand for Biomedical Research Reagents and Kits III-1 Application-Oriented Products Herald a Technological Upheaval III-1 Competition - Highly Prevalent III-2 Review of US Cell/Tissue Culture Supplies Market III-2 Industrial Segment -Largest End-User III-2 Rise in Cell Culture Equipment Demand Leads to Innovation III-3 Factors Influencing the Market for Media III-3 Fetal Bovine Serum - Use on a Decline III-3

Table 28: Leading Producers of Fetal Bovine Serum in the US (2004): Percentage Breakdown of Value Sales for Life Technologies, Hyclone, and Others (includes corresponding Graph/Chart) III-3 Suppliers Searching for New Areas III-4 Serum Free Products Market: Rapidly Growing III-4 Immunoassay Reagents III-4

Table 29: Leading Players in the US Immunoassay Reagents Market (2004): Percentage Breakdown of Value Sales (*) for Abbott Diagnostics, Dade Behring, Roche Diagnostics, Beckman Coulter, and Others (includes corresponding Graph/Chart) III-4 Issues Affecting the US Immunodiagnostics Market III-5 Technological Innovations Play a Vital Role III-5 Chromatography Reagents Market to Register Strong Growth III-5

Table 30: US Market for Chromatography Reagents (2007): Percentage Breakdown of Sales of Reagents by Application/Technique (includes corresponding Graph/Chart) III-5 Molecular Biological Reagents III-6 Rapidly Growing Market III-6

Table 31: Molecular Biology Reagents Market in the US (2004): Percentage Breakdown of Value Sales by End use for Academic User, Biotech industry, Pharmaceuticals, and Government (includes corresponding Graph/Chart) III-6 DNA Sequencing: Gaining Prominence III-6 Key Players III-7 Product Launches III-11 Strategic Developments III-21 B.Market Analytics III-41

Table 32: US Recent Past, Current & Future Analysis for Biotechnology Reagents by Product Segment - Cell/Tissue Culture Reagents, DNA Sequencing/Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-41

Table 33: US Long-term Projections for Biotechnology Reagents by Product Segment - Cell/Tissue Culture Reagents, DNA Sequencing/ Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-42

Table 34: US 10-Year Perspective for Biotechnology Reagents by Product Segment - Percentage Breakdown of Dollar Sales for Cell/Tissue Culture Reagents, DNA Sequencing/ Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents Markets for 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-43

2. Canada III-44 A.Market Analysis III-44 Current & Future Analysis III-44 Biotech Sector in Canada III-44 Outlook III-44 Strategic Developments III-44 B.Market Analytics III-45

Table 35: Canadian Recent Past, Current & Future Analysis for Biotechnology Reagents by Product Segment - Cell/Tissue Culture Reagents, DNA Sequencing/Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-45

Table 36: Canadian Long-term Projections for Biotechnology Reagents by Product Segment - Cell/Tissue Culture Reagents, DNA Sequencing/ Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-46

Table 37: Canadian 10-Year Perspective for Biotechnology Reagents by Product Segment - Percentage Breakdown of Dollar Sales for Cell/Tissue Culture Reagents, DNA Sequencing/ Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents Markets for 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-47

3. Japan III-48 A.Market Analysis III-48 Biotech Scenario III-48 Outlook III-49

Table 38: Japanese Market for Biotechnology (2010F): Percentage Breakdown of Revenues by End-Use Application - Medical Care, Food, Bio Tools & Information, Environment & Energy, and Others (includes corresponding Graph/Chart) III-49 Product Launches III-49 Strategic Developments III-50 B.Market Analytics III-52

Table 39: Japanese Recent Past, Current & Future Analysis for Biotechnology Reagents by Product Segment - Cell/Tissue Culture Reagents, DNA Sequencing/Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-52

Table 40: Japanese Long-term Projections for Biotechnology Reagents by Product Segment - Cell/Tissue Culture Reagents, DNA Sequencing/ Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-53

Table 41: Japanese 10-Year Perspective for Biotechnology Reagents by Product Segment - Percentage Breakdown of Dollar Sales for Cell/Tissue Culture Reagents, DNA Sequencing/ Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents Markets for 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-54

4. Europe III-55 A.Market Analysis III-55 Biotechnology in Europe on an Expansion Spree III-55 PCR Technology - An Overview III-55 Technological Advancements Drive PCR Market III-55 Product Launches III-56 Strategic Developments III-56 B.Market Analytics III-58

Table 42: European Recent Past, Current & Future Analysis for Biotechnology Reagents by Geographic Region - France, Germany, Italy, UK, and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-58

Table 43: European Long-term Projections for Biotechnology Reagents by Geographic Region - France, Germany, Italy, UK, and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-59

Table 44: European 10-Year Perspective for Biotechnology Reagents by Product Segment - Percentage Breakdown of Dollar Sales for France, Germany, Italy, UK, and Rest of Europe for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-60

Table 45: European Recent Past, Current & Future Analysis for Biotechnology Reagents by Product Segment - Cell/Tissue Culture Reagents, DNA Sequencing/Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart) III-61

Table 46: European Long-term Projections for Biotechnology Reagents by Product Segment - Cell/Tissue Culture Reagents, DNA Sequencing/ Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-62

Table 47: European 10-Year Perspective for Biotechnology Reagents by Product Segment - Percentage Breakdown of Dollar Sales for Cell/Tissue Culture Reagents, DNA Sequencing/ Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-63

4a. France III-64 A.Market Analysis III-64 BioMérieux SA - A Key Player III-64 Strategic Developments III-64 B.Market Analytics III-65

Table 48: French Recent Past, Current & Future Analysis for Biotechnology Reagents by Product Segment - Cell/ Tissue Culture Reagents, DNA Sequencing/Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-65

Table 49: French Long-term Projections for Biotechnology Reagents by Product Segment - Cell/Tissue Culture Reagents, DNA Sequencing/ Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-66

Table 50: French 10-Year Perspective for Biotechnology Reagents by Product Segment - Percentage Breakdown of Dollar Sales for Cell/Tissue Culture Reagents, DNA Sequencing/ Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-67

4b. Germany III-68 A.Market Analysis III-68 German Biotech Industry Review III-68 Outlook III-68 Strategic Development III-69 B.Market Analytics III-70

Table 51: German Recent Past, Current & Future Analysis for Biotechnology Reagents by Product Segment - Cell/Tissue Culture Reagents, DNA Sequencing/Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-70

Table 52: German Long-term Projections for Biotechnology Reagents by Product Segment - Cell/Tissue Culture Reagents, DNA Sequencing/ Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-71

Table 53: German 10-Year Perspective for Biotechnology Reagents by Product Segment - Percentage Breakdown of Dollar Sales for Cell/Tissue Culture Reagents, DNA Sequencing/ Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-72

4c. Italy III-73 A. Market Analysis III-73 Strategic Development III-73 B.Market Analytics III-74

Table 54: Italian Recent Past, Current & Future Analysis for Biotechnology Reagents by Product Segment - Cell/Tissue Culture Reagents, DNA Sequencing/Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-74

Table 55: Italian Long-term Projections for Biotechnology Reagents by Product Segment - Cell/Tissue Culture Reagents, DNA Sequencing/ Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-75

Table 56: Italian 10-Year Perspective for Biotechnology Reagents by Product Segment - Percentage Breakdown of Dollar Sales for Cell/Tissue Culture Reagents, DNA Sequencing/ Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-76

4d. The United Kingdom III-77 A.Market Analysis III-77 Research Entities III-77 Commercial Activities III-77 GE Healthcare - A Key Player III-76 Product Launches III-78 Strategic Developments III-78 B.Market Analytics III-80

Table 57: UK Recent Past, Current & Future Analysis for Biotechnology Reagents by Product Segment - Cell/Tissue Culture Reagents, DNA Sequencing/Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-80

Table 58: UK Long-term Projections for Biotechnology Reagents by Product Segment - Cell/Tissue Culture Reagents, DNA Sequencing/ Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-81

Table 59: UK 10-Year Perspective for Biotechnology Reagents by Product Segment - Percentage Breakdown of Dollar Sales for Cell/Tissue Culture Reagents, DNA Sequencing/ Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-82

4e. Rest of Europe III-83 A.Market Analysis III-83 Medical Device Market in Spain III-83 Russian Clinical Diagnostic Equipment and Supplies Market III-83 Major Reagent Producers III-83 Roche Diagnostics Ltd. (Switzerland) - A Key Player III-83 Product Launches III-84 Strategic Developments III-85 B.Market Analytics III-88

Table 60: Rest of Europe (*) Market for Biotechnology Reagents - Recent Past, Current & Future Analysis by Product Segment for Cell/Tissue Culture Reagents, DNA Sequencing/Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-88

Table 61: Rest of Europe Long-term Projections for Biotechnology Reagents by Product Segment - Cell/Tissue Culture Reagents, DNA Sequencing/ Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-89

Table 62: Rest of Europe 10-Year Perspective for Biotechnology Reagents by Product Segment - Percentage Breakdown of Dollar Sales for Cell/Tissue Culture Reagents, DNA Sequencing/ Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-90

5. Asia-Pacific III-91 A.Market Analysis III-91 Biotechnology- A Burgeoning Market III-91 Impact of IPR on Biotechnology Market III-91 Asia-Pacific - A Lucrative R&D Base III-91 Focus on Key Biotechnology Markets III-92 India III-92 China III-92 Korea III-93 Clinical Lab Products Market in Korea III-93 Product Launches III-93 Strategic Developments III-93 B.Market Analytics III-96

Table 63: Asia-Pacific Market for Biotechnology Reagents - Recent Past, Current & Future Analysis by Product Segment for Cell/Tissue Culture Reagents, DNA Sequencing/Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-96

Table 64: Asia-Pacific Long-term Projections for Biotechnology Reagents by Product Segment - Cell/Tissue Culture Reagents, DNA Sequencing/ Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-97

Table 65: Asia-Pacific 10-Year Perspective for Biotechnology Reagents by Product Segment - Percentage Breakdown of Dollar Sales for Cell/Tissue Culture Reagents, DNA Sequencing/ Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry Reagents, Immunoassay Reagents, Liquid Chromatography Reagents, Polymerase Chain Reaction Reagents, and Protein Synthesis Reagents Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-98

6. Latin America III-99 A.Market Analysis III-99 The Brazilian Biotech Industry: An Overview III-99

Table 66: Biotechnology Industry in Brazil (2004): Percentage Breakdown of Revenues Generated by State (includes corresponding Graph/Chart) III-99

Table 67: Biotechnology Industry in Brazil (2004): Percentage Breakdown by End-Use Sector - Human Health, Government & International Biotechnology Companies, Consumables Suppliers, Equipment, Agribusiness, Animal Health, and Environment (includes corresponding Graph/Chart) III-100 B.Market Analytics III-101

Table 68: Latin American Market for Biotechnology Reagents - Recent Past, Current & Future Analysis by Product Segment for Cell/Tissue Culture Reagents, DNA Sequencing/Sy

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