Get a Deep Insight into the World Neurostimulation Market

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World Neurostimulation Market

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This report analyzes the worldwide markets for Neurostimulation in Millions of US$. The Major product segments analyzed are Spinal Cord Stimulators (SCS) {Radio Frequency (RF) System, Implantable Pulse Generator (IPG)}, Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), and Vagus Nerve Stimulators (VNS). In addition to the above listed product segments, the report analyzes the US market for Neurostimulation by Gastric Electric Stimulators (GES). The report provides separate comprehensive analytics for the US, and Rest of World. Annual forecasts are provided for each region for the period of 2007 through 2012. A seven-year historic analysis is also provided for these markets with annual market analytics.The report profiles 29 companies including many key and niche players worldwide such as Boston Scientific Corp., Cyberonics, Inc., Medtronic, Inc., and St. Jude Medical, Inc. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources.

NEUROSTIMULATION MCP-1227 A GLOBAL STRATEGIC BUSINESS REPORT

CONTENTS

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS s Study Reliability and Reporting Limitations I-1 Disclaimers I-2 Data Interpretation & Reporting Level I-2 Quantitative Techniques & Analytics I-3 Product Definitions and Scope of Study I-3 Spinal Cord Stimulation (SCS) I-3 Radio Frequency (RF) Systems I-4 Implantable Pulse Generator Systems (IPGs) I-4 Deep Brain Stimulation (DBS) I-4 Sacral Nerve Stimulation (SNS) I-4 Vagus Nerve Stimulation (VNS) I-4

II. EXECUTIVE SUMMARY

1. Market Snapshots II-1

2. Market Overview II-2 A Historical Note II-2 Current Scenario II-2 Neurostimulation Therapy Gets Popular II-2 Technological Advancements So Far II-3 SCS - The New Painkiller II-3 Future Prospects II-3 Obesity Control to Spur Market Growth in Future II-4

3. Competitive Scenario II-5 Worldwide Neurostimulation Market: Leading Players by Product Segment II-5

Table 1: Neurostimulation Market (2004-2010): Percentage Share Breakdown by Value Sales for Medtronic, St. Jude, Boston Scientific, Cyberonics and Others (includes corresponding Graph/Chart) II-6

Table 2: Neurostimulation Market (2004-2010): Percentage Share Breakdown by Value Sales for Pain, Deafness, Epilepsy, Movement Disorders, Depression, Stroke, Incontinence, Gastroparesis and Obesity II-6 Product Offerings of Leading Players in the Neurostimulation Market II-7 Select Spinal Cord Stimulation Product Offerings of St. Jude and Medtronic II-7 Stimulation Parameters of Select SCS Products II-8 Companies Researching Neurostimulator Applications by Indication II-8

4. Trends and Issues II-9 Chip Makers Struggle to Meet Quality Demand II-9 Market Growth Attracts New Investors II-9 Neurostimulation on a Rise with Growing Indications II-9 Neurostimulation Market Marked by High Entry Barriers II-9 Increasing Acceptance of Neurostimulation due to Advanced Clinical Benefits II-10 Powering Neurostimulation Devices - The Key to Success II-10 Market Development Initiatives to Fuel Market Growth II-10 Exploring Market Opportunities - The Technology Way II-11 Neurostimulation Devices - Growing Awareness and Acceptance Among Physicians II-11 Synergy with Pharma & Biotech Companies Creates New Avenues II-11 Third-Party Reimbursement - A Vital Role to Play II-12

5. Current and Future Analysis II-13 Spinal Cord Stimulators Dominate the Market... II-13 Deep Brain Stimulators and Vagus Nerve Stimulators Witness Rapid Growth II-13

Table 3: Worldwide Neurostimulation Market (2007-2012): Product Segments (Spinal Cord Stimulators, Deep Brain Stimulators, Sacral Nerve Stimulators, and Vagus Nerve Stimulators) Ranked by Growth (includes corresponding Graph/Chart) II-13

Table 4: Worldwide Neurostimulation Market (2008E): Market Value & Percentage Market Share by Product Segment (includes corresponding Graph/Chart) II-14

6. Neuromodulation Industry: An Insight II-15 Attacking the Source of Pain - The Logic behind Neuromodulation II-15 Growth Prospects for Neuromodulation Industry II-15

7. Product Overview II-17 Neurostimulation Devices by Product Segment II-17 Spinal Cord Stimulation (SCS) II-18 SCS - What it Treats II-18 Segmentation by Type of Power Source II-18 ImplanTablePulse Generator Systems (IPGs) II-19 Radio Frequency (RF) Systems II-19 Market Assessment for RF Systems II-19 Sacral Nerve Stimulation (SNS) II-20 Deep Brain Stimulation (DBS) II-20 Vagus Nerve Stimulation (VNS) II-21 Gastric Electric Stimulation (GES) II-21 Stimulation Device - How it Works II-22 Neurostimulation & its Benefits II-22 Prospective Application Areas for Neurostimulators - Select Indications II-22 Neurostimulation Indications and the Related Devices/Techniques II-23 Approved Indications for Spinal Cord Stimulation by Geographic Regions II-24 Neurostimulation Devices - Technology & Safety Issues II-24

8. Research and Development II-25 Sacral-Nerve Stimulation could Tame Incontinence II-25 A Study of VNS for Cognition in Alzheimer's Disease II-25 DBS - An Emerging Therapy for Treatment of Parkinson's and Dystonia II-26 VNS Therapy Depicts Enduring Benefits for Chronic or Recurrent Depression II-26

9. Recent Industry Activity II-28 Cyberkinetics and Neurometrix Form Joint Venture to Develop Andara™ OFS™ II-28 Medtronic Receives FDA Approval to Market Restore ULTRA™ II-28 St. Jude Bags CE Mark and FDA Approvals for Eon Mini™ II-28 St. Jude Medical Initiates Clinical Study of DBS II-29 ANS Bags CE Mark Approval for Rapid Programmer 3.0 II-29 Northstar Completes Trial of Renova-ST™ II-29 Greatbatch Acquires Enpath Medical II-29 Greatbatch to Acquire Quan Emerteq II-29 Critical Therapeutics Grants Global License to Innovative Metabolics II-30 Biomet Merges with LVB Acquisition II-30 US Patent and Trademark Office Issues Cyberkinetics' Patent for Andara™OFS™ Therapy II-30 Cyberonics Licenses Obesity-Related Patents II-31 Stryker Invests in Afferent Corp II-31 Medtronic Receives PMA Approval for Specify™ 5-6-5 Surgical Lead II-31 BioControl Initiates CardioFit™ System’s Trials II-31 Medtronic Initiates Post-Market Study of Inter Stim™ II-31 Cyberkinetics Successfully Tests Andara™OFS™ System II-31 Medtronic Completes Implants in SANTE Trial of Deep Brain Stimulation II-32 Cyberonics Receives US FDA Approval for Demipulse™ and Demipulse Duo™ II-32 Cyberonics Signs Licensing Agreement with Ethicon Endo-Surgery II-32 AMS Acquires ImplanTableElectrical Stimulation Platform Technology from BioControl II-32 Medtronic Bags FDA Approval on Interstim® II-32 Boston’s Precision SCS System Successfully Implanted II-32 New Computer System to Improve Efficiency of Deep Brain Stimulation II-33 Cyberonics Bags FDA Approval for Harmonized/ Modularized VNS Therapy System Labeling Format II-33 Impulse Dynamics Sponsors Study to Evaluate Optimizer II-33 Medtronic to Pursue Major Clinical Trial of DBS II-33 Cyberonics Bags FDA Real-Time Review Approval for Perennia™ Lead II-33 Northstar Chooses AMI Semiconductor II-33 American Medical Acquires Technology License from BioControl Medical II-34 American Medical Systems Holdings Takes Over the Urology Unit of MedImpulse II-34 Cyberkinetics Acquires Andara II-34 Cyberkinetics Pacts with Minnetronix II-35 Symphony Medical Strikes Deal with NDI Medical II-35 NDI Opens New Business Unit II-35 BRCP Funds Case to Extend Research Capabilities of ONNP II-35 ANS Receives Clearance on Eon for European Market II-35 Medtronic Receives FDA Nod for RestorePRIME II-35 Boston Scientific Implants PRISM II-36 Neuroscience Bags FDA Approval on P-Stim™ II-36 Victhom Receives Patents from USPTO II-36 St. Jude Acquires ANS II-36 Medtronic Acquires Transneuronix II-36 Medtronic Acquires Image-Guided Neurologics II-36 Advanced Bionics Opts invivodata’s DiaryPRO II-37 AMI Semi Associates with MagnaChip II-37 Boston Scientific Receives FDA Nod for Artisan II-37 ANS Receives MDEA II-37 Cyberkinetics Merges with Trafalgar Ventures II-37 Boston Scientific Acquires Advanced Bionics II-37 Boston Scientific Acquires Stake in Northstar Neuroscience II-38 ANSI Acquires Stake in Cyberonics II-38 Victhom Acquires Neurostream Technologies II-38 ANS Buys Assets of Medtel Pty Limited II-38 ANS Signs Supply Agreement with Eaglepicher Technologies II-39 FDA Approves First Rechargeable ImplanTableSCS System of Advanced Bionics II-39 Victhom Enters into the Licensing Agreement with PolySTIM Laboratory II-39 Boston Scientific Acquires Share in Cyberonics II-39 ANS Acquires Assets of Comedical II-39 Critical Therapeutics Enters into Licensing Agreement with LIJ II-40 ANS Acquires Pain Management Business of Sun Medical II-40 Medtronic Initiates Neurostimulation System Trials II-40 ANS to Acquire Micronet Medical II-40 ANS Inks Japan Distribution Agreement With Boston Scientific II-41 ANS Acquires Hi-Tronics Designs, Inc. II-41 Cyberonics Bags CE Mark Approval to Market its NCP System in Europe II-41 FDA Approves ANS’ Genesis IPG-SCS Device II-41 FDA Grants Humanitarian Device Exemption for Medtronics’ GES System II-42

10. Product Innovations/Introductions II-43 Medtronic Delivers Procedural Intelligence in StealthStation® System II-43 Medtronic Unveils Patient Referral Advisor Software in US II-43 Boston Scientific Introduces Smallest Rechargeable SCS System II-43 Tennessee Inventors Develops Apparatus of Deep Brain Stimulator II-44 California Inventors Develop IPG II-44 Medtronic Rolls Out Two ImplanTable Neurostimulation Systems II-44 Medtronic Introduces Two Latest Neurostimulation Systems II-44 Neuroscience Therapy Launches P-Stim Electro Stimulation Device II-45 NeuroPace and AMI Semiconductor Develops ImplanTableEpilepsy Device II-45 Neuroscience Launches P-Stim™ II-45 AMI Semiconductor to Develop ASIC for New Stroke Therapy II-45 Medtronic Unveils Two New Neurostimulation Systems II-45 ANS Launches Rapid Programmer 3.0 II-46 ANS Launches Eon Rechargeable IPG II-46 Medtronic Unveils SynergyPlus+ Neurostimulation System II-46 Medtronic’s Restore Rechargeable Neurostimulation System Approved II-46 Medtronic Unveils CD Horizon® Legacy™ 5.5 Spinal System II-47 Advanced Bionics Introduces Bion Microstimulator in the US II-47 Mayo Clinic Debuts New Deep Brain Stimulation Technique II-47 Medtronic Unveils New Extended Life Neurostimulation Lead II-47 ANS Introduces PainDoc 2.0 for Ease in Programming of SCS II-48 Medtronic Unveils N’Vision Programmer for Neurological Therapies II-48 ANS Makes Full U.S. Release of Genesis IPG Spinal Cord Stimulator II-48 Zarlink Semiconductor Debuts High Performance Surge Protection Chips II-49

11. Focus on Select Players II-50 Boston Scientific Corp. (USA) II-50 Cyberonics, Inc. (USA) II-50 Medtronic, Inc. (USA) II-50 St. Jude Medical, Inc. (USA) II-51

12. Global Market Perspective II-52

Table 5: World Recent Past, Current & Future Analysis for Neurostimulation by Geographic Region - United States and Rest of the World Markets Independently Analyzed with Annual Sales Figures in US$ Million for the Years 2007 through 2012 (includes corresponding Graph/Chart) II-52

Table 6: World Historic Review for Neurostimulation by Geographic Region - United States and Rest of the World Markets Independently Analyzed with Annual Sales Figures in US$ Million for the Years 2000 through 2006 (includes corresponding Graph/Chart) II-52

Table 7: World 10-Year Perspective for Neurostimulation by Geographic Region - Percentage Breakdown of Value Sales for United States and Rest of the World Markets for the Years 2003, 2008 and 2012 II-53

Table 8: World Recent Past, Current & Future Analysis for Spinal Cord Stimulators by Geographic Region - United States and Rest of the World Markets Independently Analyzed with Annual Sales Figures in US$ Million for the Years 2007 through 2012 (includes corresponding Graph/Chart) II-54

Table 9: World Recent Past, Current & Future Analysis for Spinal Cord Stimulators by Product Segment - Radio Frequency (RF) System and ImplanTablePulse Generator (IPG) Markets Independently Analyzed with Annual Sales Figures in US$ Million for the Years 2007 through 2012 (includes corresponding Graph/Chart) II-54

Table 10: World Historic Review for Spinal Cord Stimulators by Geographic Region - United States and Rest of the World Markets Independently Analyzed with Annual Sales Figures in US$ Million for the Years 2000 through 2006 (includes corresponding Graph/Chart) II-55

Table 11: World Historic Review for Spinal Cord Stimulators by Product Segment - Radio Frequency (RF) System and ImplanTablePulse Generator (IPG) Markets Independently Analyzed with Annual Sales Figures in US$ Million for the Years 2000 through 2006 (includes corresponding Graph/Chart) II-55

Table 12: World 10-Year Perspective for Spinal Cord Stimulators by Geographic Region - Percentage Breakdown of Value Sales for United States and Rest of the World Markets for the Years 2003, 2008 and 2012 II-56

Table 13: World 10-Year Perspective for Spinal Cord Stimulators by Product Segment - Percentage Breakdown of Value Sales for Radio Frequency (RF) System and ImplanTablePulse Generator (IPG) Markets for the Years 2003, 2008 and 2012 II-56

Table 14: World Recent Past, Current & Future Analysis for Radio Frequency by Geographic Region - United States and Rest of the World Markets Independently Analyzed with Annual Sales Figures in US$ Million for the Years 2007 through 2012 (includes corresponding Graph/Chart) II-57

Table 15: World Historic Review for Radio Frequency Spinal Cord Stimulators by Geographic Region - United States and Rest of the World Markets Independently Analyzed with Annual Sales Figures in US$ Million for the Years 2000 through 2006 (includes corresponding Graph/Chart) II-57

Table 16: World 10-Year Perspective for Radio Frequency by Geographic Region - Percentage Breakdown of Value Sales for United States and Rest of the World Markets for the Years 2003, 2008 and 2012 II-58

Table 17: World Recent Past, Current & Future Analysis for ImplanTablePulse Generator by Geographic Region - United States and Rest of the World Markets Independently Analyzed with Annual Sales Figures in US$ Million for the Years 2007 through 2012 (includes corresponding Graph/Chart) II-59

Table 18: World Historic Review for ImplanTablePulse Generator (IPG) Spinal Cord Stimulators by Geographic Region - United States and Rest of the World Markets Independently Analyzed with Annual Sales Figures in US$ Million for the Years 2000 through 2006 (includes corresponding Graph/Chart) II-59

Table 19: World 10-Year Perspective for ImplanTablePulse Generator by Geographic Region - Percentage Breakdown of Value Sales for United States and Rest of the World Markets for the Years 2003, 2008 and 2012 II-60

Table 20: World Recent Past, Current & Future Analysis for Deep Brain Stimulators by Geographic Region - United States and Rest of the World Markets Independently Analyzed with Annual Sales Figures in US$ Million for the Years 2007 through 2012 (includes corresponding Graph/Chart) II-61

Table 21: World Historic Review for Deep Brain Stimulators by Geographic Region - United States and Rest of the World Markets Independently Analyzed with Annual Sales Figures in US$ Million for the Years 2000 through 2006 (includes corresponding Graph/Chart) II-61

Table 22: World 10-Year Perspective for Deep Brain Stimulators by Geographic Region - Percentage Breakdown of Value Sales for United States and Rest of the World Markets for the Years 2003, 2008 and 2012 II-62

Table 23: World Recent Past, Current & Future Analysis for Sacral Nerve Stimulators by Geographic Region - United States and Rest of the World Markets Independently Analyzed with Annual Sales Figures in US$ Million for the Years 2007 through 2012 (includes corresponding Graph/Chart) II-63

Table 24: World Historic Review for Sacral Nerve Stimulators by Geographic Region - United States and Rest of the World Markets Independently Analyzed with Annual Sales Figures in US$ Million for the Years 2000 through 2006 (includes corresponding Graph/Chart) II-63

Table 25: World 10-Year Perspective for Sacral Nerve Stimulators by Geographic Region - Percentage Breakdown of Value Sales for United States and Rest of the World Markets for the Years 2003, 2008 and 2012 II-64

Table 26: World Recent Past, Current & Future Analysis for Vagus Nerve Stimulators by Geographic Region - United States and Rest of the World Markets Independently Analyzed with Annual Sales Figures in US$ Million for the Years 2007 through 2012 (includes corresponding Graph/Chart) II-65

Table 27: World Historic Review for Vagus Nerve Stimulators by Geographic Region - United States and Rest of the World Markets Independently Analyzed with Annual Sales Figures in US$ Million for the Years 2000 through 2006 (includes corresponding Graph/Chart) II-65

Table 28: World 10-Year Perspective for Vagus Nerve Stimulators by Geographic Region - Percentage Breakdown of Value Sales for United States and Rest of the World Markets for the Years 2003, 2008 and 2012 II-66

III. MARKET

1. The United States III-1 A.Market Analysis III-1 Industry Overview III-1 Current and Future Analysis III-1 Product Segments Ranked by Growth III-2

Table 29: Neurostimulation Market in the US (2007-2012): Product Segments (Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS) and Gastric Electric Stimulators (GES)) Ranked by Growth in Volume Sales (includes corresponding Graph/Chart) III-2

Table 30: Neurostimulation Market in the US (2007-2012): Product Segments (Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS) and Gastric Electric Stimulators (GES)) Ranked by Growth in Value Sales (includes corresponding Graph/Chart) III-2

Table 31: Neurostimulation Market in the US (2008): Unit Sales & Percentage Breakdown by Product Segment - Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS) and Gastric Electric Stimulators (GES (includes corresponding Graph/Chart)) III-3

Table 32: Neurostimulation Market in the US (2008): Value Sales (In US$ Million) & Percentage Market Share by Product Segment - Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS) and Gastric Electric Stimulators (GES) (includes corresponding Graph/Chart) III-3 Potential Growth for Neurostimulation Systems in the US III-4 Migraine Devices - New Frontiers for Neurostimulation III-4 Competitive Landscape III-4

Table 33: US Neurostimulation Market by Leading Players (2004-2008): Percentage Breakdown of Revenues for Medtronic, Advanced Bionics (Boston Scientific), Advanced Neuromodulation Systems/St. Jude, Cyberonics and Others (includes corresponding Graph/Chart) III-5 Product Launches III-5 Strategic Corporate Developments III-11 Review of Key Players III-25 Other Players Operating in the US Neurostimulation Market III-26 B.Market Analytics III-28

Table 34: US Recent Past, Current & Future Analysis for Neurostimulators by Product Segment - Spinal Cord Stimulators (SCS); Deep Brain Stimulators (DBS); Sacral Nerve Stimulators (SNS); Vagus Nerve Stimulators (VNS) and Gastric Electric Stimulators (GES) Markets Independently Analyzed with Annual Sales Figures in Units for the Years 2007 through 2012 (includes corresponding Graph/Chart) III-28

Table 35: US Recent Past, Current & Future Analysis for Neurostimulators by Product Segment - Spinal Cord Stimulators (SCS); Deep Brain Stimulators (DBS); Sacral Nerve Stimulators (SNS); Vagus Nerve Stimulators (VNS) and Gastric Electric Stimulators (GES) Markets Independently Analyzed with Annual Sales Figures in US$ Million for the Years 2007 through 2012 (includes corresponding Graph/Chart) III-28

Table 36: US Historic Review for Neurostimulators by Product Segment - Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS), and Gastric Electric Stimulators (GES) Markets Independently Analyzed with Annual Sales Figures in Units for the Years 2000 through 2006 (includes corresponding Graph/Chart) III-29

Table 37: US Historic Review for Neurostimulators by Product Segment - Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS), and Gastric Electric Stimulators (GES) Markets Independently Analyzed with Annual Sales Figures in US$ Million for the Years 2000 through 2006 (includes corresponding Graph/Chart) III-29

Table 38: US 10-Year Perspective for Neurostimulators by Product Segment - Percentage Breakdown of Unit Sales for Spinal Cord Stimulators (SCS); Deep Brain Stimulators (DBS); Sacral Nerve Stimulators (SNS); Vagus Nerve Stimulators (VNS) and Gastric Electric Stimulators (GES) Markets for the Years 2003, 2008 and 2012 (includes corresponding Graph/Chart) III-30

Table 39: US 10-Year Perspective for Neurostimulators by Product Segment - Percentage Breakdown of Value Sales for Spinal Cord Stimulators (SCS); Deep Brain Stimulators (DBS); Sacral Nerve Stimulators (SNS); Vagus Nerve Stimulators (VNS) and Gastric Electric Stimulators (GES) Markets for the Years 2003, 2008 and 2012 (includes corresponding Graph/Chart) III-30

Table 40: US Recent Past, Current & Future Analysis for Spinal Cord Stimulators by Product Segment - Radio Frequency (RF) System and ImplanTablePulse Generator (IPG) Markets Independently Analyzed with Annual Sales Figures in Units for the Years 2007 through 2012 (includes corresponding Graph/Chart) III-31

Table 41: US Recent Past, Current & Future Analysis for Spinal Cord Stimulators by Product Segment - Radio Frequency (RF) System and ImplanTablePulse Generator (IPG) Markets Independently Analyzed with Annual Sales Figures in US$ Million for the Years 2007 through 2012 (includes corresponding Graph/Chart) III-31

Table 42: US Historic Review for Spinal Cord Stimulators by Product Segment - Radio Frequency (RF) System and ImplanTablePulse Generator (IPG) Markets Independently Analyzed with Annual Sales Figures in Units for the Years 2000 through 2006 (includes corresponding Graph/Chart) III-32

Table 43: US Historic Review for Spinal Cord Stimulators by Product Segment - Radio Frequency (RF) System and ImplanTablePulse Generator (IPG) Markets Independently Analyzed with Annual Sales Figures in US$ Million for the Years 2000 through 2006 (includes corresponding Graph/Chart) III-32

Table 44: US 10-Year Perspective for Spinal Cord Stimulators by Product Segment - Percentage Breakdown of Unit Sales for Radio Frequency (RF) System and ImplanTablePulse Generator (IPG) Markets for the Years 2003, 2008 and 2012 III-33

Table 45: US 10-Year Perspective for Spinal Cord Stimulators by Product Segment - Percentage Breakdown of Value Sales for Radio Frequency (RF) System and ImplanTablePulse Generator (IPG) Markets for the Years 2003, 2008 and 2012 III-33

2. Rest of World III-34 A.Market Analysis III-34 Current and Future Analysis III-34 B.Market Analytics III-35

Table 46: Rest of World Recent Past, Current & Future Analysis for Neurostimulators by Product Segment - Spinal Cord Stimulators (SCS); Deep Brain Stimulators (DBS); Sacral Nerve Stimulators (SNS); Vagus Nerve Stimulators (VNS) and Gastric Electric Stimulators (GES) Markets Independently Analyzed with Annual Sales Figures in US$ Million for the Years 2007 through 2012 (includes corresponding Graph/Chart) III-35

Table 47: Rest of World Historic Review for Neurostimulators by Product Segment - Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS), and Gastric Electric Stimulators (GES) Markets Independently Analyzed with Annual Sales Figures in US$ Million for the Years 2000 through 2006 (includes corresponding Graph/Chart) III-35

Table 48: Rest of World 10-Year Perspective for Neurostimulators by Product Segment - Percentage Breakdown of Value Sales for Spinal Cord Stimulators (SCS); Deep Brain Stimulators (DBS); Sacral Nerve Stimulators (SNS); Vagus Nerve Stimulators (VNS) and Gastric Electric Stimulators (GES) Markets for the Years 2003, 2008 and 2012 (includes corresponding Graph/Chart) III-36

Table 49: Rest of World Recent Past, Current & Future Analysis for Spinal Cord Stimulators by Product Segment - Radio Frequency (RF) System and ImplanTablePulse Generator (IPG) Markets Independently Analyzed with Annual Sales Figures in US$ Million for the Years 2007 through 2012 (includes corresponding Graph/Chart) III-37

Table 50: Rest of World Historic Review for Spinal Cord Stimulators by Product Segment - Radio Frequency (RF) System and ImplanTablePulse Generator (IPG) Markets Independently Analyzed with Annual Sales Figures in US$ Million for the Years 2000 through 2006 (includes corresponding Graph/Chart) III-37

Table 51: Rest of World 10-Year Perspective or Spinal Cord Stimulators by Product Segment - Percentage Breakdown of Value Sales for Radio Frequency (RF) System and ImplanTable Pulse Generator (IPG) Markets for the Years 2003, 2008 and 2012 III-37

IV. COMPETITIVE LANDSCAPE

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