Focus on the World Ophthalmic Instrumentation Market

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World Ophthalmic Instrumentation Market

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This report analyzes the worldwide markets for Ophthalmic Instrumentation in Thousands of Units and Millions of US$. The major product segments analyzed are Diagnostic Devices (Perimeters, Refractors, Slit Lamps, Tonometers, Fundus Cameras, Lens Meters, Ophthalmoscopes, Diagnostic Ultrasound Equipment, Corneal Topography Systems, & Diagnostic Imaging Systems), and Surgical Products (Ophthalmic Disposables, Ophthalmic Lasers, & Ophthalmic Surgical Microscope). The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, The Middle East, and Latin America. Annual forecasts are provided for each region for the period of 2001 through 2015. A five-year historic analysis is also provided for these markets with annual market analytics. The report profiles 144 companies including many key and niche players worldwide such as Advanced Medical Optics, Inc, Alcon Laboratories, Bausch & Lomb, Inc., Carl Zeiss Meditec AG, Ellex Medical Pty Ltd, Iridex Corp., Lumenis Ltd., Nidek Co. Ltd., Topcon Corporation, and Topcon Medical Systems. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources.

OPHTHALMIC INSTRUMENTATION MCP-3346 A GLOBAL STRATEGIC BUSINESS REPORT

CONTENTS

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

Study Reliability and Reporting Limitations I-1 Disclaimers I-2 Data Interpretation & Reporting Level I-2 Quantitative Techniques & Analytics I-3 Product Definitions and Scope of Study I-3 Diagnostic Devices I-4 Perimeters I-4 Refractors I-4 Slit Lamps I-4 Tonometers I-4 Fundus Cameras I-4 Ophthalmoscopes I-4 Diagnostic Ultrasound Equipment I-4 Corneal Topography Systems I-4 Diagnostic Imaging Systems I-5 Surgical Products I-5 Ophthalmic Lasers I-5 Ophthalmic Surgical Microscopes I-5 Ophthalmic Disposables I-5

II. EXECUTIVE SUMMARY

1. Global Market Overview and Analysis II-1 Current and Future Analysis II-1 Outlook II-1 Eyeing the Ophthalmic Potential II-1 Factors Underpinning Demand for Ophthalmic Instrumentation II-1 Cataract Surgical Market: Providing Lucrative Opportunities II-1

Table 1: Global Cataract Surgery Market by Segment: 2008 (In US$ Million) (includes corresponding Graph/Chart) II-2 Laser Springs Changes in the Ophthalmic Surgery Market II-2 Diagnostics Ride the Sophistication Wave II-3 Demographics Spell Opportunities II-3

Table 2: Worldwide Distribution of Population by Country/ Region: 2004 (includes corresponding Graph/Chart) II-3

Table 3: Worldwide Population by Age Group: 2002 & 2005 (includes corresponding Graph/Chart) II-4

Table 4: Worldwide Distribution of 65+ Population by Region/Country: 2005 (includes corresponding Graph/Chart) II-4

Table 5: Global Population Growth Trends for 65+ Population (2005-2035)(in millions) (includes corresponding Graph/ Chart) II-4 Ophthalmic Fact File II-5 Impact of Advanced Technologies II-5 Integration of Ophthalmology and Material Science II-5

2. Competitive Dynamics II-7 Consolidation Throws Open New Opportunities II-7

Table 6: Leading Players in the Worldwide Ophthalmic Devices Market (2004 & 2005E): Market Share by Value Sales for Carl Zeiss, Topcon, Visx, Nidek, Bausch & Lomb, Alcon, and Others (includes corresponding Graph/Chart) II-7

Table 7: Leading Players in the Global Cataract Surgery Market (2003-05E): Percentage Share Breakdown by Leading Players by Value Sales for Alcon, Advanced Medical Optics, Bausch & Lomb, STAAR, and Others (includes corresponding Graph/Chart) II-8 Acquisition and Merger Activity: 2000-2008 II-8

Table 8: Distribution of Ophthalmic Devices by Treatment Modality: 2004 (includes corresponding Graph/Chart) II-9 Worldwide Ophthalmic Diagnostic Market: Select Participants by Product Segment- Historic Data II-9

3. Product Overview II-10 Introduction II-10 Ophthalmology and Instrumentation II-10 Human Eye Analysis – A Valuable Health Indicator II-10 Types of Ophthalmic Instruments II-10 A. Ophthalmic Diagnostic Instruments II-11 Ophthalmic Diagnostics Goes High Tech II-11 The Constituents II-11 Procedures for Measuring Eye Defects II-11 Perimeters II-11 Refractometer II-12 Slit Lamps II-12 Tonometers II-12 Fundus Cameras and Fundus Reflectometers II-13 Ocular Fundus Reflectometry II-13 Types of Ocular Fundus Reflectometry II-13 Lens Meters II-14 Ophthalmoscopes II-15 Ultrasound Equipment II-15 Corneal Topography Systems II-15 Use of Corneal Topography in Data Measurement and Presentation II-15 Method of Studying Topographic Displays II-15 Use of Topography in Refractive Surgery: II-16 B. Ophthalmic Surgical Products II-17 Ophthalmic Disposables II-17 Ophthalmic Lasers II-17 Role of Lasers in Medical and Ophthalmic Fields II-17 Market for Ophthalmic Lasers II-18 Origin and Development of Laser Surgery Techniques II-18 Types of Lasers II-18 Therapeutic Ophthalmic Lasers II-19 Argon Laser II-20 Q-switched Nd-YAG Laser II-20 Krypton Laser II-21 CO2 Laser II-21 Diode Laser II-21 Erbium Lasers II-21 Excimer Laser II-21 Excimer Lasers Available in the Market II-22 Frequency-Doubled, Tripled, Quadrupled Lasers II-22 Laser Sources for Surgical Effect II-22 Laser-Tissue Interactions II-23 Laser Photodisruption II-23 Laser Photocoagulation II-23 Role of Iris Color II-24 Disadvantages of Using Laser Scalpel II-24 Laser Phaco II-25 Ophthalmic Surgical Microscopes II-25 Other Ophthalmic Devices II-25 Keratometers II-25 Phaco Splitter II-25 Scalpel II-26 Ophthalmodynamometer II-26 Ophthalmodiaphanoscope II-26

4. Ophthalmic Surgery Market – Technologies and Trends II-27

Market Structure II-27

Table 9: Global Ophthalmic Surgery Market Breakdown by Surgery Procedure (includes corresponding Graph/Chart) II-27 A. Cataract Surgery II-27

Table 10: Global Cataract Market by Region: 2004 (includes corresponding Graph/Chart) II-27 Cataract Surgical Disposable Devices Market Worldwide II-27 B. Refractive Surgery II-28 Types of Refractive Surgery Procedures II-28 Laser Vision Correction – A Broader Insight II-29 Photorefractive Keratectomy (PRK) II-29 Bottlenecks in PRK Procedure II-30 Radial Keratotomy (RK) II-30 Laser in-situ Keratomileusis (LASIK) II-31 LASIK Vs. PRK II-31 Custom LASIK - A New Milestone II-32 Advantages of Custom LASIK technology II-32 Wavefront: A Revolutionary Technology for Irregular Astigmatism II-32 Manufacturers Offering Wavefront Technology II-33 Femtosecond Laser – A New Innovation II-33 The Process II-33 Other Alternative Refractive Procedures II-33 LASEK (Laser Epithelial Keratomileusis): II-33 PAI (Photoablative Inlay): II-34 Phototherapeutic Keratectomy (PTK) II-34 Intrastromal Corneal Ring (Intacs) II-34 Phakic Intraocular Lenses II-34

5. An Insight into Eyes & Eye Diseases II-35 Human Eyes – The Most Precious Possession II-35 Anatomy of Human Eye II-35 Process of Vision II-35 Effect of Sun Rays II-35 A Review of Various Eye Diseases II-36 A. Corneal Diseases II-36

Table 11: Leading Causes of Blindness Worldwide - 2005 (includes corresponding Graph/Chart) II-36 Macular Degeneration II-36 Cataract II-37 Types of Cataracts and their Common Causes II-37 Cataract Removal Techniques II-37 Phacoemulsification II-37 Glaucoma II-38 Surgical Treatment of Glaucoma II-38 Angiogenesis II-38 Astigmatism II-38 Presbyopia II-39 B. Ocular Defects Related to Nutritional Disorders II-39 Xerophthalmia, Caused by Vitamin A Deficiency II-39 Deficiency of Thiamine Leads to Amblyopia II-39 Retinal Anemia and Optic Atrophy Due to Vitamin B-12 Deficiency II-39 Vitamin C Deficiency Leads to Eye Related Hemorrhages II-39 C. Common Eye Related Problems Among Diabetics II-39 Blurred Vision II-39 Cataract in Diabetics (Differing from Normal Cataract) II-40 Macular Edema II-40 Mucormycosis II-40 Diplopia II-40 Gout II-41 Wilson’s Disease II-41 Hyperlipoproteinemias II-41 Ocular Albinism II-41 Keratoconus II-42

6. Product Developments/Introductions II-43 Topcon Unveils TRC-NW8 Retinal Camera II-43 Topcon Launches 4-in-1 TRK-1P II-43 Topcon Unveils DC-3 Digital Camera II-43 Topcon Launches OMS-710 Surgical Microscope II-43 Carl Zeiss Meditec Rolls Out Humphrey Field Analyzer II-i II-44 Carl Zeiss Launches VisuMax® laser system II-44 Zecotek Photonics Introduces SL 1.4 Fiber Coupled Laser II-44 DRE Rolls Out Om2100 Ophthalmic Microscope II-44 Carl Zeiss Unveils i-Scription® Solution II-44 Ophthalmic Imaging Systems to Roll out Three New Products II-45 BD Medical Unveils BD Visitec Disposable Instruments II-45 Konan Medical Introduces Specular Microscope Series II-45 Wavelight Launches a Prototype of Concept System 1000 II-45 Bausch & Lomb Unveils a New Vision Enhancement System, Stellaris™ II-45 AMO Introduces New Refractive Technologies In The European Market II-46 Keeler Launches Next Generation Tonometer, Pulsair intelliPuff® II-46 Carl Zeiss Rolls Out Two New OPMI Surgical Microscopes II-46 NIDEK Launches a New Fundus Camera II-47 Keeler Unveils Spectra Plus Ophthalmoscope II-47 OptiMedica Rolls out New Line of Products II-47 Lumenis Launches Aura™ PT and Selecta® Lasers, and Novus® 3000 Photocoagulator II-47 FDA Approves Marketing of Optyse Lens Free Ophthalmoscope II-48 Optos Gains FDA’s Marketing Clearance for its P200MA Laser Ophthalmoscope II-48 Lumenis Receives FDA’s Marketing Approval for its Novus 3000 Photocoagulator II-48 FDA Grants Approval for Marketing Alcon’s LADAR6000™ Excimer Laser II-48 Bausch & Lomb Receives FDA Approval for Marketing Zyoptix ™ Excimer Laser II-48 Carl Zeiss Develops MedLive® Trio Eye™ Camera for Ophthalmology Surgery II-49 NIDEK Launches Enhanced Auto Ref/Keratometer & Auto Refractometer Products II-49 NIDEK Unveils OPD-Scan II ARK-10000 for Improved Vision Assessment Quality II-49 STAAR Gains European CE Mark for its KS-3Ai Preloaded Aspheric Silicone IOL II-49 CMS Designates AMO’s Tecnis® Foldable IOL as New Technology IOL II-50 CMS Designates AcrySof® IQ IOL as a New Technology IOL II-50 STAAR Submits PMA Application for Gaining FDA Approval for Visian TICL™ II-50 Ellex Medical Unveils New Integre Duo Red/Green Photocoagulator II-50 FDA Grants Marketing Approval for Ellex Medical’s Integre Duo Photocoagulator II-50

7. Recent Industry Activity II-51 AMO Obtains FDA Approval for its Advanced Femtosecond Laser II-51 OptiMedica Signs Deal with Topcon for Distributing PASCAL II-51 Essilor Expands Operations in Eastern Europe II-51 Bausch & Lomb Acquires eyeonics II-51 Advanced Medical Optics and Bausch & Lomb Ink Patent Agreement II-52 STAAR Surgical Acquires Stake in Canon Staar II-52 Ellex Medical Lasers Completes the Acquisition of Innovative Imaging II-52 OccuLogix Acquires Stake in OcuSense II-52 OPKO Health Acquires Ophthalmic Technologies II-52 Affiliates of Warburg Pincus Complete the Acquisition of Bausch & Lomb II-53 Reichert Acquires Pachymeter Products from Portable Ophthalmic Devices II-53 OccuLogix Completes SOLX Acquisition II-53 Carl Zeiss Acquires Acri.Tec II-53 Volk Optical Signs two Distribution Agreements with Synergetics II-54 Nidek Commences a New Plant in Italy II-54 OptiMedica Enters into a Distribution Agreement with Topcon Europe Medical II-54 Topcon Obtains FDA Approval for its 3D OCT-1000 II-54 Essilor of America Takes Over Majority Interest in OOGP II-54 Froptix, Acuity and eXegenics Merge to Form Opko Corporation II-55 NIDEK Obtains FDA Approval for ORION Auto-Retinal Imaging Device II-55 Ellex Obtains FDA Approval for Marketing 30XL Laser Slit Lamp II-55 Optos Enters into an Agreement with Pearl Vision II-55 IRIDEX and Synergetics Settle All Litigations II-55 Ellex Forays into Chinese Ophthalmic Laser Market II-56 Advanced Medical Optics Acquires IntraLase II-56 Advanced Medical Optics Takes Over WaveFront Sciences II-56 Bausch & Lomb Invests in AcuFocus II-57 Gebauer Establishes Subsidiary in the US II-57 Ellex Signs MoU to Acquire Coherent Lasers II-57 OIS Partners with IVN to Distribute Digital Imaging Systems II-57 Synergetics to Distribute Quantel’s Ophthalmic Laser in US and Canada II-58 NIDEK Merges with NTA to Enhance Ophthalmic Product Offering II-58 Ellex Medical Re-Brands its Ophthalmic Laser Systems II-58 Lumenis Bags Global Rights for SRT™ Laser Technology II-58 AMO Acquires VISX II-59 NIDEK Commences New Plant in Italy II-59 SOLA Amalgamated into Carl Zeiss Ophthalmic Lens Division II-59 LaserSight and WaveLight enter Global Licensing Agreement II-60 Advanced Medical Acquires Pfizer's Ophthalmic Surgical Devices Business II-60 Carl Zeiss Meditec Acquires Laser Diagnostic Technologies II-60 LaserSight Signs Pact with WaveLight II-60 CIBA Divests Surgical Business II-60 Visionix Acquires Luneau II-61 Carl Zeiss Meditec Sells Dermatological and Dental Laser Divisions II-61 MediVision Subsidiary OIS Signs Licensing Agreement Merger Creates Carl Zeiss Meditec II-61 Allergan Completes Spin off of Advanced Medical Optics II-62 ESC Acquires Coherent Medical Group to form Lumenis II-62 Bausch & Lomb Creates New Ophthalmic Surgical Division II-62 Alcon Laboratories Acquires Summit/Autonomous II-63 MediVision Acquires Stake in OIS II-63 Escalon Medical Corp Acquires Sonomed II-63 Bausch & Lomb Acquires Groupe Chauvin II-63

8. Focus on Select Global Players II-64 Advanced Medical Optics, Inc. (US) II-64 Alcon Laboratories (US) II-64 Bausch & Lomb, Inc. (US) II-65 Carl Zeiss Meditec AG (Germany) II-65 Ellex Medical Pty Ltd (Australia) II-66 Iridex Corp (US) II-66 Lumenis Ltd. (Israel) II-67 Nidek Co Ltd (Japan) II-67 Topcon Corporation (Japan) II-68 Topcon Medical Systems (US) II-68

9. Global Market Perspective II-69 I. Analytics in Units II-69

Table 12: World Recent Past, Current & Future Analysis for Ophthalmic Instrumentation by Geographic Region – US, Canada, Japan, Europe, Asia-Pacific, the Middle East, and Latin America Independently Analyzed with Annual Sales Figures in ‘000Units for Years 2001 through 2010 (includes corresponding Graph/Chart) II-69

Table 13: World Long-term Projections for Ophthalmic Instrumentation by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific, the Middle East, and Latin America- Independently Analyzed with Annual Sales Figures in ‘000 Units for Years 2011 through 2015 (includes corresponding Graph/Chart) II-70

Table 14: World Historic Review for Ophthalmic Instrumentation by Geographic Region – US, Canada, Japan, Europe, Asia-Pacific, the Middle East, and Latin America Independently Analyzed with Annual Sales Figures in ‘000 Units for Years 1995 through 2000 (includes corresponding Graph/Chart) II-71

Table 15: World 10-Year Perspective for Ophthalmic Instrumentation by Geographic Region – Percentage Breakdown of Volume Sales for US, Canada, Japan, Europe, Asia-Pacific, the Middle East, and Latin America for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-72 Analytics By Product Segment II-73

Table 16: World Recent Past, Current & Future Analysis for Ophthalmic Instrumentation by Product Segment– Ophthalmic Diagnostic Devices and Ophthalmic Surgical Devices Markets Independently Analyzed with Annual Sales Figures in ‘000 Units for Years 2001 through 2010 (includes corresponding Graph/Chart) II-73

Table 17: World Long-term Projections for Ophthalmic Instrumentation by Product Segment- Ophthalmic Diagnostic Devices and Ophthalmic Surgical Devices Markets Independently Analyzed with Annual Sales Figures in ‘000 Units for Years 2011 through 2015 (includes corresponding Graph/Chart) II-73

Table 18: World Historic Review for Ophthalmic Instrumentation by Product Segment– Ophthalmic Diagnostic Devices by Product Segment– Ophthalmic Diagnostic Devices and Ophthalmic Surgical Devices Markets Independently Analyzed with Annual Sales Figures in ‘000 Units for Years 1995 through 2000 (includes corresponding Graph/Chart) II-74

Table 19: World 10-Year Perspective for Ophthalmic Instrumentation by Product Segment- Percentage Breakdown of Volume Sales for Product Segment– Ophthalmic Diagnostic Devices and Ophthalmic Surgical Devices Markets for Years 2003, 2008 & 2012 II-74 Ophthalmic Diagnostic Devices II-75

Table 20: World Recent Past, Current & Future Analysis for Ophthalmic Diagnostic Devices by Geographic Region – US, Canada, Japan, Europe, Asia-Pacific, the Middle East, and Latin America Independently Analyzed with Annual Sales Figures in Units for Years 2001 through 2010 (includes corresponding Graph/Chart) II-75

Table 21: World Long-term Projections for Ophthalmic Diagnostic Devices by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific, the Middle East, and Latin America- Independently Analyzed with Annual Sales Figures in Units for Years 2011 through 2015 (includes corresponding Graph/Chart) II-76

Table 22: World Historic Review for Ophthalmic Diagnostic Devices by Geographic Region – US, Canada, Japan, Europe, Asia-Pacific, the Middle East, and Latin America Independently Analyzed with Annual Sales Figures in Units for Years 1995 through 2000 (includes corresponding Graph/Chart) II-77

Table 23: World 10-Year Perspective for Ophthalmic Diagnostic Devices by Geographic Region – Percentage Breakdown of Volume Sales for US, Canada, Japan, Europe, Asia-Pacific, the Middle East, and Latin America for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-78

Table 24: World Recent Past, Current & Future Analysis for Ophthalmic Diagnostic Devices by Product Segment–Corneal Topography Systems, Refractors, Perimeters, Slit Lamps, Diagnostic Ultrasound Equipment, Lens Meters, Fundus Cameras, Diagnostic Imaging Systems, Ophthalmoscopes, and Tonometers Markets Independently Analyzed with Annual Sales Figures in Units for Years 2001 through 2010 (includes corresponding Graph/Chart) II-79

Table 25: World Long-term Projections for Ophthalmic Diagnostic Devices by Product Segment- Ophthalmoscopes, Lens Meters, Slit Lamps, Tonometers, Perimeters, Corneal Topography Systems, Refractors, Diagnostic Imaging Systems, Fundus Cameras, and Diagnostic Ultrasound Equipment Markets Independently Analyzed with Annual Sales Figures in Units for Years 2011 through 2015 (includes corresponding Graph/Chart) II-80

Table 26: World Historic Review for Ophthalmic Diagnostic Devices by Product Segment–Corneal Topography Systems, Refractors, Perimeters, Slit Lamps, Diagnostic Ultrasound Equipment, Lens Meters, Fundus Cameras, Diagnostic Imaging Systems, Ophthalmoscopes, and Tonometers Markets Independently Analyzed with Annual Sales Figures in Units for Years 1995 through 2000 (includes corresponding Graph/Chart) II-81

Table 27: World 10-Year Perspective for Ophthalmic Diagnostic Devices by Product Segment- Percentage Breakdown of Volume Sales for Product Segment–Corneal Topography Systems, Refractors, Perimeters, Slit Lamps, Diagnostic Ultrasound Equipment, Lens Meters, Fundus Cameras, Diagnostic Imaging Systems, Ophthalmoscopes, and Tonometers Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-82 Ophthalmic Surgical Devices II-83

Table 28: World Recent Past, Current & Future Analysis for Ophthalmic Surgical Devices by Geographic Region – US, Canada, Japan, Europe, Asia-Pacific, the Middle East, and Latin America Independently Analyzed with Annual Sales Figures in Units for Years 2001 through 2010 (includes corresponding Graph/Chart) II-83

Table 29: World Long-term Projections for Ophthalmic Surgical Devices by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific, the Middle East, and Latin America Independently Analyzed with Annual Sales Figures in Units for Years 2011 through 2015 (includes corresponding Graph/Chart) II-84

Table 30: World Historic Review for Ophthalmic Surgical Devices by Geographic Region – US, Canada, Japan, Europe, Asia-Pacific, the Middle East, and Latin America Independently Analyzed with Annual Sales Figures in Units for Years 1995 through 2000 (includes corresponding Graph/Chart) II-85

Table 31: World 10-Year Perspective for Ophthalmic Surgical Devices by Geographic Region – Percentage Breakdown of Volume Sales for US, Canada, Japan, Europe, Asia-Pacific, the Middle East, and Latin America for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-86 Ophthalmic Surgical Devices by Product Segment II-87

Table 32: World Recent Past, Current & Future Analysis for Ophthalmic Surgical Devices by Product Segment–Ophthalmic Lasers, and Ophthalmic Surgical Microscopes markets Independently Analyzed with Annual Sales Figures in Units for Years 2001 through 2010 (includes corresponding Graph/Chart) II-87

Table 33: World Long-term Projections for Ophthalmic Surgical Devices by Product Segment–Ophthalmic Lasers and Ophthalmic Surgical Microscopes Markets Independently Analyzed with Annual Sales Figures in Units for Years 2011 through 2015 (includes corresponding Graph/Chart) II-87

Table 34: World 10-Year Perspective for Ophthalmic Surgical Devices by Product Segment– Percentage Breakdown of Volume Sales for Product Segment– Ophthalmic Lasers, and Ophthalmic Surgical Microscopes for Years 2003, 2008 & 2012 II-88 II. Analytics in Dollars II-89

Table 35: World Recent Past, Current & Future Analysis for Ophthalmic Instrumentation by Geographic Region – US, Canada, Japan, Europe, Asia-Pacific, the Middle East, and Latin America Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) II-89

Table 36: World Long-term Projections for Ophthalmic Instrumentation by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific, the Middle East, and Latin America Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-90

Table 37: World Historic Review for Ophthalmic Instrumentation by Geographic Region – US, Canada, Japan, Europe, Asia-Pacific, the Middle East, and Latin America Independently Analyzed with Annual Sales Figures in US$ Million for Years 1995 through 2000 (includes corresponding Graph/Chart) II-91

Table 38: World 10-Year Perspective for Ophthalmic Instrumentation by Geographic Region – Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific, the Middle East, and Latin America for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-92 Analytics by Segment II-93

Table 39: World Recent Past, Current & Future Analysis for Ophthalmic Diagnostic Devices by Product Segment– Ophthalmic Diagnostic Devices and Ophthalmic Surgical Devices Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) II-93

Table 40: World Long-term Projections for Ophthalmic Instrumentation by Product Segment- Ophthalmic Diagnostic Devices and Ophthalmic Surgical Devices Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-93

Table 41: World Historic Review for Ophthalmic Diagnostic Devices by Product Segment– Ophthalmic Diagnostic Devices by Product Segment– Ophthalmic Diagnostic Devices and Ophthalmic Surgical Devices Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1995 through 2000 (includes corresponding Graph/Chart) II-94

Table 42: World 10-Year Perspective for Ophthalmic Diagnostic Devices by Product Segment- Percentage Breakdown of Dollar Sales for Product Segment– Ophthalmic Diagnostic Devices and Ophthalmic Surgical Devices Markets for Years 2003, 2008 & 2012 II-94 Ophthalmic Diagnostic Devices II-95

Table 43: World Recent Past, Current & Future Analysis for Ophthalmic Diagnostic Devices by Geographic Region – US, Canada, Japan, Europe, Asia-Pacific, the Middle East, and Latin America Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) II-95

Table 44: World Long-term Projections for Ophthalmic Diagnostic Devices by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific, the Middle East, and Latin America Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-96

Table 45: World Historic Review for Ophthalmic Diagnostic Devices by Geographic Region – US, Canada, Japan, Europe, Asia-Pacific, the Middle East, and Latin America Independently Analyzed with Annual Sales Figures in US$ Million for Years 1995 through 2000 (includes corresponding Graph/Chart) II-97

Table 46: World 10-Year Perspective for Ophthalmic Diagnostic Devices by Geographic Region – Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific, the Middle East, and Latin America for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-98 Ophthalmic Diagnostic Devices by Segment II-99

Table 47: World Recent Past, Current & Future Analysis for Ophthalmic Diagnostic Devices by Product Segment–Corneal Topography Systems, Refractors, Perimeters, Slit Lamps, Diagnostic Ultrasound Equipment, Lens Meters, Fundus Cameras, Diagnostic Imaging Systems, Ophthalmoscopes, and Tonometers Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) II-99

Table 48: World Long-term Projections for Ophthalmic Diagnostic Devices by Product Segment- Corneal Topography Systems, Lens Meters, Refractors, Ophthalmoscopes, Slit Lamps, Fundus Cameras, Perimeters, Diagnostic Imaging Systems, Tonometers, and Diagnostic Ultrasound Equipment Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-100

Table 49: World Historic Review for Ophthalmic Diagnostic Devices by Product Segment–Corneal Topography Systems, Refractors, Perimeters, Slit Lamps, Diagnostic Ultrasound Equipment, Lens Meters, Fundus Cameras, Diagnostic Imaging Systems, Ophthalmoscopes and Tonometers Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1995 through 2000 (includes corresponding Graph/Chart) II-101

Table 50: World 10-Year Perspective for Ophthalmic Diagnostic Devices by Product Segment- Percentage Breakdown of Dollar Sales for Product Segment–Corneal Topography Systems, Refractors, Perimeters, Slit Lamps, Diagnostic Ultrasound Equipment, Lens Meters, Fundus Cameras, Diagnostic Imaging Systems, Ophthalmoscopes, and Tonometers Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-102

Ophthalmic Surgical Devices II-103

Table 51: World Recent Past, Current & Future Analysis for Ophthalmic Surgical Devices by Geographic Region – US, Canada, Japan, Europe, Asia-Pacific, the Middle East, and Latin America Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) II-103

Table 52: World Long-term Projections for Ophthalmic Surgical Devices by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific, the Middle East, and Latin America Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-104

Table 53: World Historic Review for Ophthalmic Surgical Devices by Geographic Region – US, Canada, Japan, Europe, Asia-Pacific, the Middle East, and Latin America Independently Analyzed with Annual Sales Figures in US$ Million for Years 1995 through 2000 (includes corresponding Graph/Chart) II-105

Table 54: World 10-Year Perspective for Ophthalmic Surgical Devices by Geographic Region – Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific, the Middle East, and Latin America for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-106 Ophthalmic Surgical Devices By Segment II-107

Table 55: World Recent Past, Current & Future Analysis for Ophthalmic Surgical Devices by Product Segment–Ophthalmic Disposables, Ophthalmic Lasers, and Ophthalmic Surgical Microscopes markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) II-107

Table 56: World Long-term Projections for Ophthalmic Surgical Devices by Product Segment- Ophthalmic Disposables, Ophthalmic Lasers, and Ophthalmic Surgical Microscopes markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-107

Table 57: World Historic Review for Ophthalmic Surgical Devices by Product Segment– Ophthalmic Disposables, Ophthalmic Lasers, and Ophthalmic Surgical Microscopes markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1995 through 2000 (includes corresponding Graph/Chart) II-108

Table 58: World 10-Year Perspective for Ophthalmic Surgical Devices by Product Segment– Percentage Breakdown of Dollar Sales for Product Segment - Ophthalmic Disposables, Ophthalmic Lasers, and Ophthalmic Surgical Microscopes for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-108

III. MARKET

1. The United States III-1 A.Market Analysis III-1 Outlook III-1 Trends III-1 Ophthalmic Marketers to Catch Up on Ageing ‘Baby Boomers’ III-1 Diagnostics and Surgical Devices Get Sophisticated III-1 Fact File III-2 Growth Drivers III-2 Refractive Surgery Market III-2

Table 59: US Refractive Surgery Procedure Volumes (1996- 2004) (in million) (includes corresponding Graph/Chart) III-3

Table 60: Penetration of Intralase Procedure in the US LASIK Market: 2002- 2004 (includes corresponding Graph/Chart) III-3 Excimer Lasers Market III-3

Table 61: Market Share Breakdown of Leading Players in the US by Number of Excimer Laser Procedures (2003 & 2004) (includes corresponding Graph/Chart) III-4

Table 62: Leading Players in the US Laser Placement Market (2001): Market Share by Volume Sales for VISX, Alcon/Summit Autonomous, Nidek, Bausch & Lomb, STAAR, and Others (includes corresponding Graph/Chart) III-4 Overview of Select Products III-4 Slit Lamps III-4 Tonometers III-5 Refractors III-5 Focus on Key Players III-5 Product Launches III-9 Strategic Developments III-10 B.Market Analytics III-16 I. Market Analytics in Units III-16

Table 63: US Recent Past, Current & Future Analysis for Ophthalmic Instrumentation by Product Segment – Diagnostic Devices (Corneal Topography Systems, Refractors, Perimeters, Slit Lamps, Diagnostic Ultrasound Equipment, Lens Meters, Fundus Cameras, Diagnostic Imaging Systems, Ophthalmoscopes, and Tonometers) and Surgical Products Markets Independently Analyzed with Annual Sales Figures in Units for Years 2001 through 2010 (includes corresponding Graph/Chart) III-16

Table 64: US Long-term Projections for Ophthalmic Instrumentation by Product Segment - Diagnostic Devices (Corneal Topography Systems, Refractors, Perimeters, Slit Lamps, Diagnostic Ultrasound Equipment, Lens Meters, Fundus Cameras, Diagnostic Imaging Systems, Ophthalmoscopes, and Tonometers) and Surgical Products (Ophthalmic Lasers and Ophthalmic Surgical Microscope) Markets Independently Analyzed with Annual Sales Figures in Units for Years 2011 through 2015 (includes corresponding Graph/Chart) III-17

Table 65: US Historic Review for Ophthalmic Instrumentation by Product Segment – Diagnostic Devices (Corneal Topography Systems, Refractors, Perimeters, Slit Lamps, Diagnostic Ultrasound Equipment, Lens Meters, Fundus Cameras, Diagnostic Imaging Systems, Ophthalmoscopes, and Tonometers) and Surgical Products Markets Independently Analyzed with Annual Sales Figures in Units for Years 1995 through 2000 (includes corresponding Graph/Chart) III-18

Table 66: US 10-Year Perspective for Ophthalmic Instrumentation by Product Segment – Percentage Breakdown of Volume Sales for Diagnostic Devices (Corneal Topography Systems, Refractors, Perimeters, Slit Lamps, Diagnostic Ultrasound Equipment, Lens Meters, Fundus Cameras, Diagnostic Imaging Systems, Ophthalmoscopes, and Tonometers) and Surgical Products Markets for 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-19

II. Market Analytics in Dollars III-20

Table 67: US Recent Past, Current & Future Analysis for Ophthalmic Instrumentation by Product Segment – Diagnostic Devices (Corneal Topography Systems, Refractors, Perimeters, Slit Lamps, Diagnostic Ultrasound Equipment, Lens Meters, Fundus Cameras, Diagnostic Imaging Systems, Ophthalmoscopes, and Tonometers) and Surgical Products ( Ophthalmic Disposables, Ophthalmic Lasers, and Ophthalmic Surgical Microscope) Markets Independently Analyzed with Annual Sales Figures in US$ Thousands for Years 2001 through 2010 (includes corresponding Graph/Chart) III-20

Table 68: US Long-term Projections for Ophthalmic Instrumentation by Product Segment - Diagnostic Devices (Corneal Topography Systems, Refractors, Perimeters, Slit Lamps, Diagnostic Ultrasound Equipment, Lens Meters, Fundus Cameras, Diagnostic Imaging Systems, Ophthalmoscopes, and Tonometers) and Surgical Products (Ophthalmic Disposables, Ophthalmic Lasers, and Ophthalmic Surgical Microscope) Markets Independently Analyzed with Annual Sales Figures in US$ Thousands for Years 2011 through 2015 (includes corresponding Graph/Chart) III-21

Table 69: US Historic Review for Ophthalmic Instrumentation by Product Segment – Diagnostic Devices (Corneal Topography Systems, Refractors, Perimeters, Slit Lamps, Diagnostic Ultrasound Equipment, Lens Meters, Fundus Cameras, Diagnostic Imaging Systems, Ophthalmoscopes, and Tonometers) and Surgical Products ( Ophthalmic Disposables, Ophthalmic Lasers, and Ophthalmic Surgical Microscope) Markets Independently Analyzed with Annual Sales Figures in US$ Thousands for Years 1995 through 2000 (includes corresponding Graph/Chart) III-22

Table 70: US 10-Year Perspective for Ophthalmic Instrumentation by Product Segment – Percentage Breakdown of Dollar Sales for Diagnostic Devices (Corneal Topography Systems, Refractors, Perimeters, Slit Lamps, Diagnostic Ultrasound Equipment, Lens Meters, Fundus Cameras, Diagnostic Imaging Systems, Ophthalmoscopes, and Tonometers) and Surgical Products (Ophthalmic Disposables, Ophthalmic Lasers, and Ophthalmic Surgical Microscope) Markets for2003, 2008 & 2012 (includes corresponding Graph/Chart) III-23

2. Canada III-24 A.Market Analysis III-24 Outlook III-24 Strategic Development III-24 B.Market Analytics III-25 I. Market Analytics in Units III-25

Table 71: Canadian Recent Past, Current & Future Analysis for Ophthalmic Instrumentation by Product Segment – Diagnostic Devices (Corneal Topography Systems, Refractors, Perimeters, Slit Lamps, Diagnostic Ultrasound Equipment, Lens Meters, Fundus Cameras, Diagnostic Imaging Systems, Ophthalmoscopes, and Tonometers) and Surgical Products Markets Independently Analyzed with Annual Sales Figures in Units for Years 2001 through 2010 (includes corresponding Graph/Chart) III-25

Table 72: Canadian Long-term Projections for Ophthalmic Instrumentation by Product Segment - Diagnostic Devices (Corneal Topography Systems, Refractors, Perimeters, Slit Lamps, Diagnostic Ultrasound Equipment, Lens Meters, Fundus Cameras, Diagnostic Imaging Systems, Ophthalmoscopes, and Tonometers) and Surgical Products (Ophthalmic Lasers and Ophthalmic Surgical Microscope) Markets Independently Analyzed with Annual Sales Figures in Units for Years 2011 through 2015 (includes corresponding Graph/Chart) III-26

Table 73: Canadian Historic Review for Ophthalmic Instrumentation by Product Segment – Diagnostic Devices (Corneal Topography Systems, Refractors, Perimeters, Slit Lamps, Diagnostic Ultrasound Equipment, Lens Meters, Fundus Cameras, Diagnostic Imaging Systems, Ophthalmoscopes, and Tonometers) and Surgical Products Markets Independently Analyzed with Annual Sales Figures in Units for Years 1995 through 2000 (includes corresponding Graph/Chart) III-27

Table 74: Canadian 10-Year Perspective for Ophthalmic Instrumentation by Product Segment – Percentage Breakdown of Volume Sales for Diagnostic Devices (Corneal Topography Systems, Refractors, Perimeters, Slit Lamps, Diagnostic Ultrasound Equipment, Lens Meters, Fundus Cameras, Diagnostic Imaging Systems, Ophthalmoscopes, and Tonometers) and Surgical Products Markets for 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-28

II. Market Analytics in Dollars III-29

Table 75: Canadian Recent Past, Current & Future Analysis for Ophthalmic Instrumentation by Product Segment – Diagnostic Devices (Corneal Topography Systems, Refractors, Perimeters, Slit Lamps, Diagnostic Ultrasound Equipment, Lens Meters, Fundus Cameras, Diagnostic Imaging Systems, Ophthalmoscopes, and Tonometers) and Surgical Products (Ophthalmic Disposables, Ophthalmic Lasers, and Ophthalmic Surgical Microscope) Markets Independently Analyzed with Annual Sales Figures in US$ Thousands for Years 2001 through 2010 (includes corresponding Graph/Chart) III-29

Table 76: Canadian Long-term Projections for Ophthalmic Instrumentation by Product Segment - Diagnostic Devices (Corneal Topography Systems, Refractors, Perimeters, Slit Lamps, Diagnostic Ultrasound Equipment, Lens Meters, Fundus Cameras, Diagnostic Imaging Systems, Ophthalmoscopes, and Tonometers) and Surgical Products (Ophthalmic Disposables, Ophthalmic Lasers, and Ophthalmic Surgical Microscope) Markets Independently Analyzed with Annual Sales Figures in US$ Thousands for Years 2011 through 2015 (includes corresponding Graph/Chart) III-30

Table 77: Canadian Historic Review for Ophthalmic Instrumentation by Product Segment – Diagnostic Devices (Corneal Topography Systems, Refractors, Perimeters, Slit Lamps, Diagnostic Ultrasound Equipment, Lens Meters, Fundus Cameras, Diagnostic Imaging Systems, Ophthalmoscopes, and Tonometers) and Surgical Products (Ophthalmic Disposables, Ophthalmic Lasers, and Ophthalmic Surgical Microscope) Markets Independently Analyzed with Annual Sales Figures in US$ Thousands for Years 1995 through 2000 (includes corresponding Graph/Chart) III-31

Table 78: Canadian 10-Year Perspective for Ophthalmic Instrumentation by Product Segment – Percentage Breakdown of Dollar Sales for Diagnostic Devices (Corneal Topography Systems, Refractors, Perimeters, Slit Lamps, Diagnostic Ultrasound Equipment, Lens Meters, Fundus Cameras, Diagnostic Imaging Systems, Ophthalmoscopes, and Tonometers) and Surgical Products (Ophthalmic Disposables, Ophthalmic Lasers, and Ophthalmic Surgical Microscope) Markets for 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-32

3. Japan III-33 A.Market Analysis III-33 Outlook III-33 Higher Population of Aged Translates to Burgeoning Potential III-33 Focus on Key Players III-33 Strategic Developments III-34 B.Market Analytics III-35 I. Market Analytics in Units III-35

Table 79: Japanese Recent Past, Current & Future Analysis for Ophthalmic Instrumentation by Product Segment – Diagnostic Devices (Corneal Topography Systems, Refractors, Perimeters, Slit Lamps, Diagnostic Ultrasound Equipment, Lens Meters, Fundus Cameras, Diagnostic Imaging Systems, Ophthalmoscopes, and Tonometers) and Surgical Products Markets Independently Analyzed with Annual Sales Figures in Units for Years 2001 through 2010 (includes corresponding Graph/Chart) III-35

Table 80: Japanese Long-term Projections for Ophthalmic Instrumentation by Product Segment - Diagnostic Devices (Corneal Topography Systems, Refractors, Perimeters, Slit Lamps, Diagnostic Ultrasound Equipment, Lens Meters, Fundus Cameras, Diagnostic Imaging Systems, Ophthalmoscopes, and Tonometers) and Surgical Products (Ophthalmic Lasers and Ophthalmic Surgical Microscope) Markets Independently Analyzed with Annual Sales Figures in Units for Years 2011 through 2015 (includes corresponding Graph/Chart) III-36

Table 81: Japanese Historic Review for Ophthalmic Instrumentation by Product Segment – Diagnostic Devices (Corneal Topography Systems, Refractors, Perimeters, Slit Lamps, Diagnostic Ultrasound Equipment, Lens Meters, Fundus Cameras, Diagnostic Imaging Systems, Ophthalmoscopes, and Tonometers) and Surgical Products Markets Independently Analyzed with Annual Sales Figures in Units for Years 1995 through 2000 (includes corresponding Graph/Chart) III-37

Table 82: Japanese 10-Year Perspective for Ophthalmic Instrumentation by Product Segment – Percentage Breakdown of Volume Sales for Diagnostic Devices (Corneal Topography Systems, Refractors, Perimeters, Slit Lamps, Diagnostic Ultrasound Equipment, Lens Meters, Fundus Cameras, Diagnostic Imaging Systems, Ophthalmoscopes, and Tonometers) and Surgical Products Markets for 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-38

II. Market Analytics in Dollars III-39

Table 83: Japanese Recent Past, Current & Future Analysis for Ophthalmic Instrumentation by Product Segment – Diagnostic Devices (Corneal Topography Systems, Refractors, Perimeters, Slit Lamps, Diagnostic Ultrasound Equipment, Lens Meters, Fundus Cameras, Diagnostic Imaging Systems, Ophthalmoscopes, and Tonometers) and Surgical Products (Ophthalmic Disposables, Ophthalmic Lasers, and Ophthalmic Surgical Microscope) Markets Independently Analyzed with Annual Sales Figures in US$ Thousands for Years 2001 through 2010 (includes corresponding Graph/Chart) III-39

Table 84: Japanese Long-term Projections for Ophthalmic Instrumentation by Product Segment - Diagnostic Devices (Corneal Topography Systems, Refractors, Perimeters, Slit Lamps, Diagnostic Ultrasound Equipment, Lens Meters, Fundus Cameras, Diagnostic Imaging Systems, Ophthalmoscopes, and Tonometers) and Surgical Products (Ophthalmic Disposables, Ophthalmic Lasers, and Ophthalmic Surgical Microscope) Markets Independently Analyzed with Annual Sales Figures in US$ Thousands for Years 2011 through 2015 (includes corresponding Graph/Chart) III-40

Table 85: Japanese Historic Review for Ophthalmic Instrumentation by Product Segment – Diagnostic Devices (Corneal Topography Systems, Refractors, Perimeters, Slit Lamps, Diagnostic Ultrasound Equipment, Lens Meters, Fundus Cameras, Diagnostic Imaging Systems, Ophthalmoscopes, and Tonometers) and Surgical Products (Ophthalmic Disposables, Ophthalmic Lasers, and Ophthalmic Surgical Microscope) Markets Independently Analyzed with Annual Sales Figures in US$ Thousands for Years 1995 through 2000 (includes corresponding Graph/Chart) III-41

Table 86: Japanese 10-Year Perspective for Ophthalmic Instrumentation by Product Segment – Percentage Breakdown of Dollar Sales for Diagnostic Devices (Corneal Topography Systems, Refractors, Perimeters, Slit Lamps, Diagnostic Ultrasound Equipment, Lens Meters, Fundus Cameras, Diagnostic Imaging Systems, Ophthalmoscopes, and Tonometers) and Surgical Products (Ophthalmic Disposables, ophthalmic Lasers, and Ophthalmic Surgical Microscope) Markets for 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-42

4. Europe III-43 A.Market Analysis III-43 Outlook III-43 Population Trends III-43 Refractive Surgery Market III-43 Product Launches and Developments III-43 B.Market Analytics III-45 I. Market Analytics in Units III-45 Table 87: European Recent Past, Current & Future Analysis for Ophthalmic Instrumentation by Geographic Region – France, Germany, Italy, UK, Spain, Russia & Rest of Europe Markets Independently A

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