CombiMatrix Advances Capability of Influenza Array; Protocols for Identifying Drug Resistance Are Being Developed

NEWPORT BEACH, Calif.--(BUSINESS WIRE)--May 10, 2006--Acacia Research Corporation announced today that its CombiMatrix group (Nasdaq:CBMX) (Nasdaq:ACTG) launched an updated version of its Influenza A array incorporating new sequences that have become available in the last 30 days. CombiMatrix's Influenza A Typing Microarray is a component of the company's Electrochemical Influenza Surveillance System. This system is being evaluated under the U.S. National Early Detection System for Avian Influenza, directed by the U.S. Department of Agriculture, Department of the Interior, and the Department of Health and Human Services in collaboration with State regulatory agencies.

The CombiMatrix Influenza A Typing Microarray can identify all strains of Influenza A, including bird and human varieties. CombiMatrix's system, by tracking changes in genetic makeup of the virus, can differentiate highly pathogenic from less-lethal flu strains and can identify strains that may be resistant to drug therapy. Additional work related to drug resistance is being conducted now.

“In addition, we are now looking at key mutations that we feel may guide therapy by identifying drug resistant strains.”

In addition, this system can detect mixed or multiple infections of influenza. This has been identified as a critical issue for identifying infectious "carriers" of the disease, such as birds that are able to infect others with the H5 virus but themselves have no symptoms.

"One of the strengths of our technology is the ability to immediately update our DNA array with the most recently discovered sequence information. Our development tools enable this in a rapid and efficient manner," stated Dr. Amit Kumar, President and CEO of CombiMatrix. "In addition, we are now looking at key mutations that we feel may guide therapy by identifying drug resistant strains."


Acacia Research Corporation comprises two operating groups, Acacia Technologies group and CombiMatrix group.

The CombiMatrix group is developing a platform technology to rapidly produce customizable arrays, which are semiconductor-based tools for use in identifying and determining the roles of genes, gene mutations and proteins. The CombiMatrix's group's technology has a wide range of potential applications in the areas of genomics, proteomics, biosensors, drug discovery, drug development, diagnostics, combinatorial chemistry, material sciences and nanotechnology.

The Acacia Technologies group develops, acquires, and licenses patented technologies. Acacia controls 42 patent portfolios, which include over 160 U.S. patents, and certain foreign counterparts, covering technologies used in a wide variety of industries including audio/video enhancement & synchronization, broadcast data retrieval, computer memory cache coherency, credit card fraud protection, database management, data encryption & product activation, digital media transmission (DMT(R)), digital video production, dynamic manufacturing modeling, enhanced Internet navigation, hearing aid ECS, image resolution enhancement, interactive data sharing, interactive television, laptop docking station connectivity, microprocessor enhancement, multi-dimensional bar codes, network data storage, resource scheduling, rotational video imaging, spreadsheet automation, user activated Internet advertising and web conferencing & collaboration software.

Acacia Research-Acacia Technologies (Nasdaq:ACTG) and Acacia Research-CombiMatrix (Nasdaq:CBMX) are both classes of common stock issued by Acacia Research Corporation and are intended to reflect the performance of the respective operating groups and are not issued by the operating groups.

Information about the Acacia Technologies group and the CombiMatrix group is available at

Safe Harbor Statement under the Private Securities Litigation Reform Act of 1995:

This news release contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995. These statements are based upon our current expectations and speak only as of the date hereof. Our actual results may differ materially and adversely from those expressed in any forward-looking statements as a result of various factors and uncertainties, including the economic slowdown affecting technology companies, our ability to successfully develop products, rapid technological change in our markets, changes in demand for our future products, legislative, regulatory and competitive developments and general economic conditions. Our Annual Report on Form 10-K, recent and forthcoming Quarterly Reports on Form 10-Q, recent Current Reports on Forms 8-K and 8-K/A, and other SEC filings discuss some of the important risk factors that may affect our business, results of operations and financial condition. We undertake no obligation to revise or update publicly any forward-looking statements for any reason.


Acacia Research Corporation
Bret L. Undem (Media Relations), 425-493-2293
Fax: 425-493-2010

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