Arrowhead Accelerates Capital Contribution to Insert Therapeutics as Nanotech Cancer Drug Heads toward Human Clinical Trials
Insert's lead anti-cancer drug, IT-101, has achieved complete remission of non-small cell lung cancer and Ewing's sarcoma, and significant knockdown of other tumor types in preclinical results in mouse xenografts, showing promise across a wide range of cancers. The company is currently preparing to enter IT-101 into human clinical trials at the City of Hope Comprehensive Cancer Center in Duarte, Calif.
“We have continued confidence in the power of Insert's technology”
"We have continued confidence in the power of Insert's technology," said R. Bruce Stewart, president of Arrowhead. "This contribution satisfies our funding obligation and solidifies our 68.5 percent ownership in this subsidiary."
Insert Therapeutics controls a portfolio of U.S. and foreign issued patents and pending applications covering therapeutics based on linear cyclodextrin-containing polymers, which comprises Insert's Cyclosert(TM) family of drug delivery polymers. IT-101 is a combination of Insert's proprietary Cyclosert platform and the potent anti-cancer compound camptothecin. Camptothecin has never been approved for use in humans due to its insolubility, toxicity, instability in human blood serum and poor pharmacokinetics, but approved analogues of the drug, irinotecan and topotecan, have demonstrated $1 billion in reported annual sales worldwide. In the mouse xenograft studies against a variety of cancer types, camptothecin enhanced by conjugation with Cyclosert proved to be more effective at lower doses compared to irinotecan.
Cyclosert was invented in the Caltech lab of chemical engineering professor and Insert founder Dr. Mark Davis, who used "molecular design" to create Cyclosert. This methodology involves the design and construction of functional materials using molecular building blocks.
For more information about Cyclosert and Insert's preclinical results, visit Insert's website at www.insertt.com.
About Arrowhead Research Corporation
Arrowhead Research Corporation (www.arrowheadresearch.com) is a diversified nanotechnology company structured to commercialize products expected to have revolutionary impacts on a variety of industries, including materials, electronics, life sciences, and energy.
There are three strategic components to Arrowhead's business model:
-- Outsourced R&D Program: Arrowhead identifies patented or patent-pending technologies at universities or government labs and funds additional development of those technologies in exchange for exclusive rights to commercialize the resulting prototypes. Leveraging the resources and infrastructure of these institutions provides Arrowhead with a highly cost-effective development pipeline. Currently, Arrowhead is supporting efforts in stem cell technology, and nanosensors at the California Institute of Technology and Stanford University.
-- Commercialization Program: After prototypes have been sufficiently developed in the laboratories, Arrowhead forms or acquires majority-owned subsidiaries to commercialize the technology and provides the subsidiaries with strategic, managerial, and operational support. At present, Arrowhead owns majority interest in subsidiaries commercializing diverse technologies, including anti-cancer drugs, RNAi therapeutics, and compound semiconductor materials.
-- The Patent Toolbox: Arrowhead has acquired or exclusively licensed patents and patent applications covering a broad range of nanotechnology. The Company is actively seeking to add to this intellectual property portfolio.
Safe Harbor Statement under the Private Securities Litigation Reform Act of 1995:
This news release contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995. These statements are based upon our current expectations and speak only as of the date hereof. Our actual results may differ materially and adversely from those expressed in any forward-looking statements as a result of various factors and uncertainties, including the recent economic slowdown affecting technology companies, the future success of our scientific studies, our ability to successfully develop products, rapid technological change in our markets, changes in demand for our future products, legislative, regulatory and competitive developments and general economic conditions. Our Annual Report on Form 10-K and 10-K/A, recent and forthcoming Quarterly Reports on Form 10-Q and 10-Q/A, recent Current Reports on Forms 8-K and 8-K/A, our Registration Statement on Form S-3, and other SEC filings discuss some of the important risk factors that may affect our business, results of operations and financial condition. We undertake no obligation to revise or update publicly any forward-looking statements for any reason.