Arrowhead Accelerates Capital Contribution to Insert Therapeutics as Nanotech Cancer Drug Heads toward Human Clinical Trials
Insert's lead anti-cancer drug, IT-101, has achieved complete remission of non-small cell lung cancer and Ewing's sarcoma, and significant knockdown of other tumor types in preclinical results in mouse xenografts, showing promise across a wide range of cancers. The company is currently preparing to enter IT-101 into human clinical trials at the City of Hope Comprehensive Cancer Center in Duarte, Calif.
“This contribution satisfies our funding obligation and solidifies our 68.5 percent ownership in this subsidiary.”
"We have continued confidence in the power of Insert's technology," said R. Bruce Stewart, president of Arrowhead. "This contribution satisfies our funding obligation and solidifies our 68.5 percent ownership in this subsidiary."
Insert Therapeutics controls a portfolio of U.S. and foreign issued patents and pending applications covering therapeutics based on linear cyclodextrin-containing polymers, which comprises Insert's Cyclosert(TM) family of drug delivery polymers. IT-101 is a combination of Insert's proprietary Cyclosert platform and the potent anti-cancer compound camptothecin. Camptothecin has never been approved for use in humans due to its insolubility, toxicity, instability in human blood serum and poor pharmacokinetics, but approved analogues of the drug, irinotecan and topotecan, have demonstrated $1 billion in reported annual sales worldwide. In the mouse xenograft studies against a variety of cancer types, camptothecin enhanced by conjugation with Cyclosert proved to be more effective at lower doses compared to irinotecan.
Cyclosert was invented in the Caltech lab of chemical engineering professor and Insert founder Dr. Mark Davis, who used "molecular design" to create Cyclosert. This methodology involves the design and construction of functional materials using molecular building blocks.
For more information about Cyclosert and Insert's preclinical results, visit Insert's website at www.insertt.com.
About Arrowhead Research Corporation
Arrowhead Research Corporation (www.arrowheadresearch.com) is a diversified nanotechnology company structured to commercialize products expected to have revolutionary impacts on a variety of industries, including materials, electronics, life sciences, and energy.
There are three strategic components to Arrowhead's business model:
-- Outsourced R&D Program: Arrowhead identifies patented or patent-pending technologies at universities or government labs and funds additional development of those technologies in exchange for exclusive rights to commercialize the resulting prototypes. Leveraging the resources and infrastructure of these institutions provides Arrowhead with a highly cost-effective development pipeline. Currently, Arrowhead is supporting efforts in stem cell technology, and nanosensors at the California Institute of Technology and Stanford University.
-- Commercialization Program: After prototypes have been sufficiently developed in the laboratories, Arrowhead forms or acquires majority-owned subsidiaries to commercialize the technology and provides the subsidiaries with strategic, managerial, and operational support. At present, Arrowhead owns majority interest in subsidiaries commercializing diverse technologies, including anti-cancer drugs, RNAi therapeutics, and compound semiconductor materials.
-- The Patent Toolbox: Arrowhead has acquired or exclusively licensed patents and patent applications covering a broad range of nanotechnology. The Company is actively seeking to add to this intellectual property portfolio.
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