Rohm and Haas Increases Support for Pharmaceutical Customers with the ART of Formulation

PHILADELPHIA--(BUSINESS WIRE)--Rohm and Haas’ Ion Exchange Resin Division has brought together its Advanced Release Technologies with its FloVitro™ dissolution test methodology, in order to offer a much-needed service for developing oral drug formulations. The service will offer a cost-effective way for customers to reduce their development time and greatly facilitate their formulation needs. Rohm and Haas will provide services ranging from simple, initial screening studies, to the development of resinates (Drug-Resin complexes), supported by FloVitro™ dissolution test methodology.

Rohm and Haas Advanced Release Technologies have long been solving a wide range of formulation issues such as stability, poor solubility, low melting point, deliquescence/hygroscopicity, polymorphism, taste-masking or controlled release for numerous commercial drugs. A leader in ion exchange for more than 60 years, its Amberlite™ and Duolite™ Ion Exchange Resins are supplied in powder form and manufactured according to cGMP standards. These products are well known and globally recognized excipients, and have a long history of safe use at high dosage. Rohm and Haas’s patented buccal dissolution test methodology has been demonstrated to correlate with human taste perception to evaluate taste masking in liquid and dissolve-in-the-mouth dosage forms.

FloVitro™ technology is a new, patented in-vitro dissolution test method that handles ion exchange resins and is compatible with all common oral dosage forms. This method will be used to demonstrate the dissolution profile of the formulations as they are developed. FloVitro™ technology has the unique ability to generate dissolution curves that match plasma profiles directly without the need for mathematical modeling. “Dissolution is critical for absorption and bioavailability, and for product quality assessments during drug product life cycle,” says Lyn Hughes, Rohm and Haas Healthcare Technology Manager. “Rohm and Haas FloVitro™ dissolution testing technology gives an unprecedented level of IVIVC in a completely in-vitro test. This allows more options to be tested more quickly and reduces time and development costs.” The FloVitro™ technology is available from Rohm and Haas either as an analytical service or for use under license.

Rohm and Haas will be exhibiting their comprehensive service at AAPS Annual Meeting and Expo (booth N° 961). On November 20^th a poster entitled “Exploring Suitability and Feasibility of a Novel In Vitro Dissolution System” featuring Rohm and Haas FloVitro™ technology will be presented by the FDA.

For more information, please visit our website www.theartofformulation.com.

About Rohm and Haas Ion Exchange Resins

For more than 60 years, Rohm and Haas has been a leading developer and manufacturer of premium ion exchange resins, adsorbents and polymeric catalysts. These products are used to purify fluids, isolate and recover active ingredients, and catalyze organic reactions. Rohm and Haas’ extensive know-how in polymer chemistry enables the development of innovative, functionalized polymers servicing a variety of industries and applications including; electrical power generation, semiconductor fabrication, pharmaceutical manufacture and formulations, chemical and petrochemical processing, food and beverage purification, and the production of potable water.

About Rohm and Haas Company

Leading the way since 1909, Rohm and Haas is a global pioneer in the creation and development of innovative technologies and solutions for the specialty materials industry. The company’s technologies are found in a wide range of industries including: Building and Construction, Electronics and Electronic Devices, Household Goods and Personal Care, Packaging and Paper, Transportation, Pharmaceutical and Medical, Water, Food and Food Related, and Industrial Process. Innovative Rohm and Haas technologies and solutions help to improve life every day, around the world. Based in Philadelphia, PA, the company generated annual sales of approximately $8.9 billion in 2007. Visit www.rohmhaas.com for more information. imagine the possibilities™