The research study covers the present scenario and growth prospects of the global chiral chromatography column market for 2017-2021. To calculate the market size, the analysts use the revenue generated from the sales of chiral chromatography column systems.
The global chiral chromatography column market is predominantly driven by advances in technology leading to the development of fast and robust chiral chromatography systems. This has led to the high-throughput purification of biomolecules, which consume less time and retain the chemical properties of molecules. Therefore, the adoption of chiral chromatography column systems by pharmaceutical, biotechnology, biopharmaceuticals, academic research laboratories, food, and agriculture, and environmental testing agencies has increased.
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Technavio analysts highlight the following three factors that are contributing to the growth of the global chiral chromatography column market:
Chromatography tests for drug approvals
Separation of chiral compounds has increasing importance in the pharmaceutical industry. The chirality of molecules causes a biological system to exhibit different responses to each enantiomer in a drug. The body is selective in chiral compounds. It interacts with racemate drug differently and metabolizes each enantiomer into different end products. Thus, while one enantiomer may produce desired therapeutic effect, another may be inactive or harmful.
Amber Chourasia, a lead lab equipment research analyst at Technavio, says, “This has resulted in the increased use of chiral chromatography to separate two or more enantiomers present in the drugs. Furthermore, various guidelines issued by the US Food and Drug Administration recommend that for a chiral drug, only its therapeutic active isomer will be marketed.”
Rising use of chiral chromatography for food authenticity and accuracy of aroma
Chirality is a common property of food components such as proteins and carbohydrate. Proteins composed of amino acids are usually in L- form while carbohydrates are D- saccharides. Enantiomers show different reactions with biologically active compounds of living organisms. The chiral structure of proteins is used to recognize their taste and aroma, which can be analyzed by chiral chromatography.
“Contrary to popular belief that nature produces optically pure isomers, certain compounds such as primarily aromatic compounds contain pure enantiomers, often in a specific ratio of each enantiomer. Odorant enantiomers differ in their intensity and character of smell. This ratio of enantiomers in aromatic compounds is essential to ensure the optimal taste or aroma,” adds Amber.
Advantage of chiral chromatography technique over non- chromatographic techniques
Current non-chromatographic methods for analyzing enantiomers include polarimetry, nuclear magnetic resonance, isotopic dilution, and calorimetry. Polarimetry is used to measure ratio, purity, and concentration of two enantiomers while nuclear magnetic resonance quantifies the degree to which a sample contains one enantiomer more than the other.
Isotopic dilution determines the quantity of chemical substances, and calorimetry is used for polymorph assessment and distinguishing enantiomers from racemate based on melting point. However, these techniques require pure samples and cannot separate enantiomers.
- Agilent Technologies
- Thermo Fisher Scientific
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