Efforts have been made to introduce novel therapies to the AML market, but its treatment has changed little in the last 40 years. However, a number of products are currently in late-stage development for the treatment of AML, both before and after the induction of remission and relapse.
This tabular heat map framework, designed to provide an easily digestible summary of these clinical characteristics, provides detailed information on all late-stage clinical trial results for products in the AML market and Phase III pipeline. These are split along therapy lines, and are therefore reflective of the treatment algorithm used in the clinic.
All safety and efficacy endpoints reported in these trials are displayed, for both the drug and placebo groups. In addition, key study characteristics such as the size, composition and patient segment of the study population are provided. These results are presented in a visually accessible, color-coded manner in order to maximize ease of use.
The accompanying text provides a detailed analysis of the clinical benchmarks set by the current market landscape, and the anticipated changes to these benchmarks, and to the treatment algorithm, as a result of the late-stage pipeline.
- What are the clinical characteristics of currently approved therapies for AML, in terms of specific safety and efficacy parameters?
- What are the key unmet needs in this indication, and which clinical safety and efficacy parameters are the most closely linked to them?
- A number of pipeline therapies are in the late-stage pipeline for the post-relapse setting, but do they have sufficient differentiating characteristics to make a strong impact on the market and clinic?
- Which line of therapy in AML stands to benefit most from the current late-stage pipeline?
- Will current pipeline targeted therapies be able to successfully enter the market for AML, or will chemotherapy remain the treatment modality of choice in this indication for the foreseeable future?
Key Topics Covered:
1. Table of Contents
3. Marketed Products
3.1 Intensive Remission Induction Therapy
3.2 Non-Intensive Remission Induction Therapy
3.3 Consolidation Therapy
3.4 Salvage Chemotherapy
4. Pipeline Products
4.1 Changes to Intensive Remission Induction Therapy, 2015-2022
4.2 Changes to Non-Intensive Remission Induction Therapy, 2015-2022
4.3 Changes to Salvage Chemotherapy, 2015-2022
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