ARDSLEY, N.Y.--(BUSINESS WIRE)--Acorda Therapeutics, Inc. (Nasdaq:ACOR) will present new analyses of data from a Phase 1 clinical trial of cimaglermin alfa (GGF2), an investigative drug for heart failure, at the American College of Cardiology 64th Annual Scientific Session and Expo (ACC). The meeting is being held in San Diego, CA, March 14-16.
"Cimaglermin alfa represents a novel approach to the development of treatment options for heart failure, potentially acting directly to strengthen the heart and improve its ability to pump blood. Current standard of care medications control blood pressure, fluid volume and neurohormonal activation that contribute to ongoing damage. Even with optimized care, the prognosis for people with advanced heart failure is poor. More effective treatments are needed for the 5.1 million Americans living with heart failure," said Anthony Caggiano, M.D., Ph.D., Senior Vice President of Research and Development at Acorda. "In the Phase 1 trial, cimaglermin alfa improved ejection fraction, a measure of heart function, for as long as 90 days after a single dose. This improvement was observed on top of optimized medical therapy. Results from this trial helped inform our ongoing Phase 1b trial."
"Sustained Improvements in Cardiac Function with Single Dose Cimaglermin Alfa (GGF2) in Human Left Ventricular Systolic Dysfunction" (Poster #1146-212) will be exhibited in Poster Hall B1 on Saturday, March 14th, 1:30-4:30. Daniel Lenihan, M.D., Professor of Medicine and Director, Clinical Research at the Vanderbilt University Medical Center, Division of Cardiovascular Medicine is the lead author and will present the poster.
More detailed information on the meeting can be found on the conference website: http://accscientificsession.acc.org/ACC.aspx.
Data from this study were previously presented at the American College of Cardiology 62nd Annual Scientific Session and Expo.
About Cimaglermin alfa
Cimaglermin alfa is a recombinant version of a naturally occurring growth factor that is important for cardiac development and function. In clinical development for heart failure, it may offer a unique mechanism. In preclinical studies, cimaglermin alfa acted at the level of the muscle cells, or cardiomyocytes, and is hypothesized to restore cardiomyocyte functions that are impaired in heart failure, potentially improving the heart's ability to contract and pump blood. In preclinical studies and in a Phase 1 trial, cimaglermin alfa resulted in improved contractile function. Preclinical studies suggest that it may also protect the heart structure from acute and chronic stressors.
Cimaglermin alfa is also being investigated in preclinical studies as a treatment for neurological conditions such as stroke and peripheral nerve damage.
About Acorda Therapeutics
Founded in 1995, Acorda Therapeutics is a biotechnology company focused on developing therapies that restore function and improve the lives of people with neurological disorders.
Acorda markets three FDA-approved therapies, including AMPYRA® (dalfampridine) Extended Release Tablets, 10 mg, a treatment to improve walking in patients with multiple sclerosis (MS), as demonstrated by an increase in walking speed. The Company has one of the leading pipelines in the industry of novel neurological therapies. Acorda is currently developing a number of clinical and preclinical stage therapies. This pipeline addresses a range of disorders including post-stroke walking deficits, Parkinson’s disease, epilepsy, heart failure, MS and spinal cord injury.
For more information, please visit the Company’s website at: www.acorda.com.
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