University of Bristol Collaborates with Affymetrix on Genotyping Arrays for Guaranteed Sustainability of Wheat Production

SANTA CLARA, Calif.--()--Affymetrix, Inc. (NASDAQ: AFFX) and University of Bristol, Bristol, UK, announced today that they have collaboratively designed a wheat genotyping array and analyzed data from experiments as part of an effort to understand wheat genetics and breeding with a goal of ensuring guaranteed sustainable production.

Axiom® Wheat Genotyping Array (Axiom Wheat Array), consisting of 817,000 markers, was designed for the University of Bristol as part of the Biotechnology and Biological Sciences Research Council (BBSRC)-funded Wheat Improvement Strategic Program (WISP). The aim of WISP is to produce new and novel wheat germplasm via three complementary "pillars" (landraces, synthetics, and ancestral gene introgression), each of which will broaden the pool of genetic variation in elite wheat cultivars by a different route. The design of Axiom Wheat Array is unique because it includes functional and positional annotation information for a variety of wheat species. The SNPs on Axiom Wheat Array include markers from hexaploid landraces and those from the synthetic and ancestral lines exhibiting different ploidy levels. Results from the array will be presented at the 2014 Plant and Animal Genome conference (PAG XXII), in San Diego, California.

“The results from Axiom Wheat Array are fantastic and have helped WISP achieve one of the main goals, which is to track the different segments of the 'wheat relative' line and incorporate them into hexaploid bread wheat through the breeding process. The follow-on focused arrays will offer wheat breeders the capability to understand polymorphisms between their current breeding lines,” stated Professor Keith Edwards, project leader and professor of Cereal Functional Genomics at the School of Biological Sciences and member of the Cabot Institute, University of Bristol. “We were thrilled to be able to complete the design and analysis in less than three months and in time to present the results at the Plant and Animal Genome meeting. This was made possible mainly because of the expertise, commitment, and collaborative efforts of the bioinformatics and product support teams at Affymetrix.”

“We are pleased to be able to support the goals of the University of Bristol and contribute efforts to help sustain wheat production in the face of challenges from a growing world population and climate change,” said Dr. Andy Last, Executive Vice President and Chief Operating Officer at Affymetrix. “The Axiom platform enables researchers to publish results sooner and breeders to accelerate their genomic programs. The platform’s superior capabilities are transforming and modernizing custom genotyping capabilities accessible to the agricultural, scientific, and applied community at large.”

A subset of the 817,000 markers found on Axiom Wheat Array will be transferred with 100 percent fidelity onto Axiom 384HT-format arrays to create multiple focused wheat array designs. Each of these Axiom wheat array designs will contain approximately 35,000 markers and each design is expected to serve a different purpose in wheat breeding. The 384HT format enables ultra high-throughput processing of 384 samples simultaneously and will be used to screen thousands of samples in a highly cost-effective manner. Affymetrix will make these new Axiom arrays publicly available before the spring wheat season.

With Affymetrix’ advanced bioinformatics and innovative design strategies, Axiom genotyping array designs routinely support genome-wide genotyping and accurately call the genotypes of both diploid and polyploid species.

The Axiom Wheat Genotyping arrays in the 384HT format will complement the catalog of Axiom Genotyping Arrays for Agrigenomics that are available for multiple species including salmon, maize, strawberry, rose, bovine, chicken, and buffalo. These products have been used for genome-wide association studies, quantitative trait locus mapping, genome mapping, and breeding activities that make use of marker-assisted selection and genomic selection. As scientists make progress in decoding genomes of various plants, animals, and fish using next-generation sequencing platforms, they can advance their research and commercial objectives by translating those discoveries to routine applications on the Axiom platform.

To learn more about the Axiom Genotyping Solution, please visit www.affymetrix.com/agrigenotyping for applications in agrigenomics.

PLEASE NOTE: Affymetrix, the Affymetrix logo, Axiom, and all other trademarks are the property of Affymetrix, Inc. All other trademarks are the property of their respective owners.

SOURCE: Affymetrix, Inc.

Forward-looking statements

All statements in this press release that are not historical are "forward-looking statements" within the meaning of Section 21E of the Securities Exchange Act as amended, including statements regarding Affymetrix' "expectations," "beliefs," "hopes," "intentions," "strategies," or the like. Such statements are subject to risks and uncertainties that could cause actual results to differ materially for Affymetrix from those projected. These and other risk factors are discussed in Affymetrix' Form 10-K for the year ended December 31, 2012, and other SEC reports for subsequent quarterly periods.

About Affymetrix

Affymetrix technologies enable multiplex and simultaneous analysis of biological systems at the cell, protein, and gene level, facilitating the rapid translation of bench-top research into clinical and routine use for human health and wellness.

The Company provides leadership and support, partnering with customers in pharmaceutical, diagnostic, and biotechnology companies, as well as leading academic, government, and non-profit research institutes in their quest to use biology for a better world.

More than 2,300 microarray systems have been shipped around the world and more than 48,000 peer-reviewed papers have been published citing Affymetrix technologies. Affymetrix is headquartered in Santa Clara, California, and has manufacturing facilities in Cleveland, Ohio, San Diego, Vienna, and Singapore. The Company has about 1,100 employees worldwide and maintains sales and distribution operations across Europe, Asia, and Latin America. For more information about Affymetrix, please visit www.affymetrix.com.

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Affymetrix, Inc.
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408-731-5523
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Contacts

Affymetrix, Inc.
Media Contact:
Mindy Lee-Olsen
Vice President, Marketing Services
408-731-5523
mindy_lee-olsen@affymetrix.com
or
Investor Contact:
Doug Farrell
Vice President, Investor Relations
408-731-5285
doug_farrell@affymetrix.com