ChemoFx® Chemoresponse Assay Identifies Platinum-Resistance in Primary Ovarian Cancer Patients

PITTSBURGH--()--Precision Therapeutics, a leading life-science company dedicated to the improvement of patient outcomes in personalized medicine, today announced findings that support the ChemoFx® chemoresponse assay as a tool to aid in the identification of platinum resistance in primary ovarian cancer, according to a presentation at the Annual Meeting of The Western Association of Gynecologic Oncologists (WAGO) June 26-29, in Seattle, Washington. This scientific poster was chosen for display at the WAGO conference due to the significance of the scientific discovery for treating primary ovarian cancer patients.

Carboplatin/paclitaxel combination therapy is the standard of care in treating women with primary ovarian cancer. While most women will initially respond to first-line treatment, the vast majority will eventually relapse. Platinum status is classified at the time of relapse and aids in determining future prognosis and subsequent treatment strategies.

In this observational, multi-site study, 276 patients diagnosed as primary, FIGO stage III-IV ovarian, peritoneal or fallopian tube cancer were treated with carboplatin/paclitaxel, following cytoreductive surgery, and association of progression-free survival with ChemoFx® assay results for carboplatin or paclitaxel was analyzed individually and jointly. Tumors that were resistant to carboplatin in vitro were associated with an increased risk of disease progression compared to those that were sensitive (HR=1.97, p=0.0009), which was independent of other clinical covariates in multivariate analysis (HR=1.71, p=0.013). A similar trend was also observed in patients that showed in vitro resistance to both carboplatin and paclitaxel (HR=1.66, p=0.017).

These findings provide clinically valuable information about an individual patient's prognosis and how likely it is that the patient would benefit from the use of the ChemoFx assay to determine platinum resistance or sensitivity in the primary ovarian cancer setting. Determining platinum status earlier in primary ovarian cancer may prevent this high-risk group of patients from being exposed to multiple cycles of ineffective therapy and allow for more effective alternate therapeutic options earlier in disease, with the ultimate goal of improving patient outcomes.

The primary author of the research is Thomas C. Krivak, M.D. Dr. Krivak is the Assistant Director of Gynecologic Oncology, Director Clinical Research in Gynecologic Oncology, West Penn Allegheny Health System, Department of Obstetrics and Gynecology, Pittsburgh PA.

“The results of this study answer the clinical question of whether ChemoFx can identify platinum-resistant/refractory primary ovarian patients,” said Dr. Krivak. “Determining the platinum status of a patient earlier in the disease may help in the selection of the most effective treatment upfront, with minimal exposure to ineffective and often intolerable therapy. Additionally, having a better understanding of the tumor and chemotherapy resistance could justify the use of bevacizumab or other targeted agents.”

About Precision Therapeutics

Precision Therapeutics, a leading life-science company based in Pittsburgh, Pennsylvania, is dedicated to utilizing precision medicine for personalized cancer care. Precision offers a portfolio of products developed to help guide physicians and patients with difficult clinical decisions throughout the cancer care continuum. The company’s leading products for personalized cancer care include ChemoFx®, a proprietary, CLIA-certified and commercially-available chemoresponse assay which measures an individual’s tumor response to a range of therapeutic alternatives under consideration by the treating physician and BioSpeciFx®, a select portfolio of clinically relevant molecular tests that provide information about drug response and patient prognosis. For more information, please visit www.precisiontherapeutics.com.

Contacts

Precision Therapeutics Inc.
Pam Ranallo, 412-432-1500 ext. 1502
pranallo@ptilabs.com

Release Summary

ChemoFx Identifies Platinum Resistance. WAGO 2013

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Contacts

Precision Therapeutics Inc.
Pam Ranallo, 412-432-1500 ext. 1502
pranallo@ptilabs.com